Association of serum osteoprotegerin and osteoprotegerin gene polymorphism with subclinical carotid artery atherosclerosis and disease activity in rheumatoid arthritis patients

Alkady, Eman A.M.; Selim, Zahraa I.; Sayed, Sohair K.; Yousef, Hosam A.; Farrag, Sara; El-Hakeim, Eman H.

doi:10.1016/j.ejr.2020.05.003

Cited by 1 publication

(2 citation statements)

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“…Discrepancies concerning the association between OPG polymorphisms and cardiovascular diseases may be related to several circumstances, such as the number of patients included in every study and the technique used for genotyping and the number of SNPs evaluated. (a) We determined four SNPs and we used CT to evaluate the CAC score, whereas the report by Alkady et al [ 32 ] was based in the intima–media thickness by echography as a subrogate of atherosclerosis and they only analyzed one polymorphism. Considering that OPG is involved in the calcification process in tissues, the lack of association in the study by Alkady et al [ 32 ] is not surprising, whereas we defined SA by the presence of coronary calcification.…”

Section: Discussionmentioning

confidence: 99%

“…(a) We determined four SNPs and we used CT to evaluate the CAC score, whereas the report by Alkady et al [ 32 ] was based in the intima–media thickness by echography as a subrogate of atherosclerosis and they only analyzed one polymorphism. Considering that OPG is involved in the calcification process in tissues, the lack of association in the study by Alkady et al [ 32 ] is not surprising, whereas we defined SA by the presence of coronary calcification. (b) The report by Soufi et al included just 468 male patients with and without CAD, as compared to the 1413 participants in our study.…”

Section: Discussionmentioning

confidence: 99%

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Osteoprotegerin Gene Polymorphisms Are Associated with Subclinical Atherosclerosis in the Mexican Mestizo Population

et al. 2022

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Subclinical atherosclerosis (SA) is the presence of coronary calcification in the absence of cardiovascular symptoms, and it usually progresses to atherosclerotic disease. Studies have shown an association of osteoprotegerin gene (OPG) variants with calcification process in cardiovascular diseases; however, to this day there are no studies that evaluate individuals in the asymptomatic stage of atherosclerotic disease. Therefore, the purpose of this study was to analyze the association of four genetic variants and haplotypes of the OPG gene with the development of SA, through TaqMan genotyping assays. We also aimed to identify potential response elements for transcription factors in these genetic variants. The study included 1413 asymptomatic participants (1041 were controls and 372 were individuals with SA). The rs3102735 polymorphism appeared as a protective marker (OR = 0.693; 95% CI = 0.493–0.974; pheterozygote = 0.035; OR = 0.699; 95% CI = 0.496–0.985; pcodominant 1 = 0.040) and two haplotypes were associated with SA, one as a decreased risk: GACC (OR = 0.641, 95% CI = 0.414–0.990, p = 0.045) and another as an increased risk: GACT (OR = 1.208, 95% CI = 1.020–1.431, p = 0.029). Our data suggest a lower risk of SA in rs3102735 C carriers in a representative sample of Mexican mestizo population.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%