Association of serum markers of oxidative stress with myocardial infarction and stroke: pooled results from four large European cohort studies

Yang, Xuan; Bobák, Martin; Anusruti, Ankita; Jansen, Eugène; Pająk, Andrzej; Tamošiūnas, Abdonas; Saum, Kai Uwe; Holleczek, Bernd; Gào, Xīn; Brenner, Hermann; Schöttker, Ben

doi:10.1007/s10654-018-0457-x

Cited by 27 publications

(25 citation statements)

References 45 publications

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“…To the best of our knowledge, there is no previous study that assessed the predictive values of d-ROMs levels or TTLs for MCE, cancer or all-cause mortality in patients with T2DM. However, several cohort studies have investigated the (11,18). In agreement with the results reported now for patients with T2DM, we observed that both d-ROMs levels and TTLs were independently and strongly associated with allcause mortality in the general population (11).…”

Section: Discussionsupporting

confidence: 91%

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Association of Serum Markers of Oxidative Stress With Incident Major Cardiovascular Events, Cancer Incidence, and All-Cause Mortality in Type 2 Diabetes Patients: Pooled Results From Two Cohort Studies

et al. 2019

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Oxidative stress plays an important role in the pathophysiology of type 2 diabetes mellitus (T2DM). However, associations of biomarkers of oxidative stress with diabetes complications have not yet been addressed in large cohort studies. RESEARCH DESIGN AND METHODS Derivatives of reactive oxygen metabolites (d-ROMs) levels, a proxy for the reactive oxygen species burden, and total thiol levels (TTLs), a proxy for the reductive capacity, were measured in 2,125 patients with T2DM from two German cohort studies of almost equal size at baseline and 3-4 years later. Multivariable adjusted Cox proportional hazards models with time-dependent modeled d-ROMs levels and TTLs were used to assess the associations with incident major cardiovascular events (MCE), cancer incidence, and all-cause mortality. RESULTS In total, 205, 179, and 394 MCE, cancer, and all-cause mortality cases were observed during 6-7 years of follow-up, respectively. Both oxidative stress biomarkers and the d-ROMs-to-TTL ratio were statistically significantly associated with all-cause mortality in both cohorts, and the pooled hazard ratios (HRs) and 95% CIs for top versus bottom tertiles were 2.10 (95% CI 1.43, 3.09) for d-ROMs levels, 0.59 (0.40, 0.87) for TTLs, and 2.50 (1.86, 3.36) for d-ROMs-to-TTL ratio. The d-ROMs-to-TTL ratio was also statistically significantly associated with incident MCE for top versus bottom tertile (1.65 [1.07, 2.54]), but this association did not persist after additional adjustment for chronic diseases. No associations with cancer were detected. CONCLUSIONS The observed strong associations of both biomarkers with mortality suggest an important contribution of an imbalanced redox system to the premature mortality of patients with diabetes.

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Section: Discussionsupporting

confidence: 91%

“…for incident CVD (MI and stroke) were much stronger for fatal than for nonfatal events (18). With respect to cancer incidence, we recently published pooled results for d-ROMs measurements from two population-based studies (ESTHER and Tromsø studies) (19).…”

Section: Discussionmentioning

confidence: 99%

Association of Serum Markers of Oxidative Stress With Incident Major Cardiovascular Events, Cancer Incidence, and All-Cause Mortality in Type 2 Diabetes Patients: Pooled Results From Two Cohort Studies

et al. 2019

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“…For additional EJE references please see [142][143][144][145][146][147][148][149][150][151][152][153][154][155][156][157][158][159][160].…”

Section: Main Results In the Last 3 Yearsunclassified

Objectives, design and main findings until 2020 from the Rotterdam Study

et al. 2020

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The Rotterdam Study is an ongoing prospective cohort study that started in 1990 in the city of Rotterdam, The Netherlands. The study aims to unravel etiology, preclinical course, natural history and potential targets for intervention for chronic diseases in mid-life and late-life. The study focuses on cardiovascular, endocrine, hepatic, neurological, ophthalmic, psychiatric, dermatological, otolaryngological, locomotor, and respiratory diseases. As of 2008, 14,926 subjects aged 45 years or over comprise the Rotterdam Study cohort. Since 2016, the cohort is being expanded by persons aged 40 years and over. The findings of the Rotterdam Study have been presented in over 1700 research articles and reports. This article provides an update on the rationale and design of the study. It also presents a summary of the major findings from the preceding 3 years and outlines developments for the coming period.

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“…3 Prognostic value of classical oxidative stress markers for cardiovascular risk. ( A ) Association of markers of lipid peroxidation (isoprostane [8-iso-PGF2α] and malondialdehyde [MDA]) [ 75 , 83 , 85 ], nitro-oxidative stress (3-nitrotyrosine [3-NT]) [ 96 ], oxidative mitochondrial DNA damage (8-hydroxy-deoxyguanosine [8-OHdG]) [ 120 ] and derivatives of reactive oxygen metabolites (d-ROMs) [ 125 ] with cardiovascular risk in the comparison of healthy subjects with cardiovascular disease patients. ( B ) Associations of d-ROM levels and total thiol levels (TTL) with cardiovascular disease-specific mortality (adjusted for age and sex).…”

Section: Classical “Oxidative Stress” Biomarkers In Human Cardiovascular Diseasementioning

confidence: 99%

Redox-related biomarkers in human cardiovascular disease - classical footprints and beyond

et al. 2021

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Global epidemiological studies show that chronic non-communicable diseases such as atherosclerosis and metabolic disorders represent the leading cause of premature mortality and morbidity. Cardiovascular disease such as ischemic heart disease is a major contributor to the global burden of disease and the socioeconomic health costs. Clinical and epidemiological data show an association of typical oxidative stress markers such as lipid peroxidation products, 3-nitrotyrosine or oxidized DNA/RNA bases with all major cardiovascular diseases. This supports the concept that the formation of reactive oxygen and nitrogen species by various sources (NADPH oxidases, xanthine oxidase and mitochondrial respiratory chain) represents a hallmark of the leading cardiovascular comorbidities such as hyperlipidemia, hypertension and diabetes. These reactive oxygen and nitrogen species can lead to oxidative damage but also adverse redox signaling at the level of kinases, calcium handling, inflammation, epigenetic control, circadian clock and proteasomal system. The in vivo footprints of these adverse processes (redox biomarkers) are discussed in the present review with focus on their clinical relevance, whereas the details of their mechanisms of formation and technical aspects of their detection are only briefly mentioned. The major categories of redox biomarkers are summarized and explained on the basis of suitable examples. Also the potential prognostic value of redox biomarkers is critically discussed to understand what kind of information they can provide but also what they cannot achieve.

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Association of serum markers of oxidative stress with myocardial infarction and stroke: pooled results from four large European cohort studies

Cited by 27 publications

References 45 publications

Association of Serum Markers of Oxidative Stress With Incident Major Cardiovascular Events, Cancer Incidence, and All-Cause Mortality in Type 2 Diabetes Patients: Pooled Results From Two Cohort Studies

Association of Serum Markers of Oxidative Stress With Incident Major Cardiovascular Events, Cancer Incidence, and All-Cause Mortality in Type 2 Diabetes Patients: Pooled Results From Two Cohort Studies

Objectives, design and main findings until 2020 from the Rotterdam Study

Redox-related biomarkers in human cardiovascular disease - classical footprints and beyond

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