Association of serum magnesium levels with glycosylated hemoglobin and degree of neuropathy in patients with diabetic peripheral neuropathy

Abstract

Introduction and Aim: Magnesium plays an important role in carbohydrate metabolism and insulin response. Deficiency of magnesium can increase the incidence of Type 2 DM and complications associated with it. Diabetic peripheral neuropathy (DPN) has become the most common chronic diabetic complication affecting about half of the diabetic patients. DPN causes debilitating complications like foot ulcers, gangrene leading to lower limb amputation reducing the quality of life in Diabetic patients. The aim of this study was to find out the levels of serum magnesium in DPN and find its association with severity of neuropathy in DPN. Materials and Methods: Total 286 participants with signs and symptoms of DPN were recruited for the study. They were classified into different severity according to their VPT scoring. Fasting and Postprandial venous blood sample were collected for estimation of FBS, HbA1C, serum Magnesium and PPBS respectively. Serum magnesium was found in different severities of neuropathy in DPN. Correlation between serum magnesium, HbA1C and severity of DPN was done. Results: Mean serum magnesium was 1.62±0.38 mg/dL. There was statistically significant decrease in serum magnesium with an increase in severity of DPN. Significant correlation was seen between serum magnesium and FBS, PPBS, HbA1C and VPT scoring in DPN patients. Conclusion: Hypomagnesemia was found to be associated with DPN and its severity suggesting low serum magnesium may affect peripheral nerve function. Hence, regular monitoring of serum magnesium should be done to prevent chronic complications related to Type2 DM.

The Relationship between Hba1c Levels and Body Mass Index with Severity of Diabetic Neuropathy at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia

“…Diabetes mellitus (DM) is a group of metabolic syndromes that is still a global health problem. 1,2 Over the last decades, the overall prevalence of diabetes mellitus has increased dramatically, mainly as a result of the prolonged increase in the incidence of type 2 diabetes mellitus. Its prevalence is rapidly becoming an epidemic in several countries around the world.…”

“…3,4,5 An increase in the prevalence of diabetes mellitus will directly lead to an increase in the prevalence of complications caused by diabetes itself. 2 Diabetic neuropathy is one of the earliest and most common diabetic microvascular complications. The most common pathophysiology underlying the occurrence of diabetic neuropathy is the condition of chronic hyperglycemia and microangiopathy that occurs in patients with diabetes mellitus.…”

“…The most common pathophysiology underlying the occurrence of diabetic neuropathy is the condition of chronic hyperglycemia and microangiopathy that occurs in patients with diabetes mellitus. 2,6 Diabetic neuropathy has the main symptoms of symmetrical paresthesias and burning pain, which generally occurs in the distal extremities. Patients with severe diabetic neuropathy are also at risk of ulceration of the distal extremity, which can lead to non-traumatic amputation.…”