Association of serum magnesium level with poor glycemic control and renal functions in Nepalese patients with type 2 diabetes mellitus

Pokharel, Daya Ram; Khadka, Dipendra; Sigdel, Manoj; Yadav, Neelu; Kafle, Ramchandra; Sapkota, Ravindra Mohan; Jha, Sanjay Kumar

doi:10.1016/j.dsx.2017.03.028

Cited by 24 publications

(22 citation statements)

References 34 publications

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“…Almost similar findings were observed in one Canadian study. 21 Serum Mg level was negatively correlated with HbA1c in different studies [22][23][24] and it is a consistent finding.…”

Section: Discussionsupporting

confidence: 58%

Serum Magnesium Level of Newly Detected Patients with Glucose Intolerance and Its Comparison with Serum Magnesium Level of Age and Sex Matched Healthy Volunteers

Rahim

Mitra

2018

J. Medicine

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Abstract Abstract Abstract Background: Background: Background: Background: Background: Hypomagnesaemia is associated with insulin resistance, diabetes mellitus (DM) and diabetic complications. Diabetic patients, on the other hand, often have low magnesium levels. This study was designed to evaluate serum magnesium level of patients with new diagnosis of any level of glucose intolerance e.g. impaired fasting glucose, impaired glucose tolerance (IGT) or DM and to compare these with serum magnesium level of age and sex matched healthy controls.

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“…Almost similar findings were observed in one Canadian study. 21 Serum Mg level was negatively correlated with HbA1c in different studies [22][23][24] and it is a consistent finding.…”

Section: Discussionsupporting

confidence: 58%

Serum Magnesium Level of Newly Detected Patients with Glucose Intolerance and Its Comparison with Serum Magnesium Level of Age and Sex Matched Healthy Volunteers

Rahim

Mitra

2018

J. Medicine

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“…These results tie with that of Lin and Huang [30] and Chen et al [32], who reported a decreased Mg level in diabetic patients compared to their normal controls. Disturbance of Mg levels in patients with diabetes also agrees with the previous reports that were conducted in other areas such as that of Odusan et al [33], in India and Pokharel et al [34], in Pakistan. Factors that might contribute to the low levels of Mg (also known as hypomagnesemia) in diabetes include impairment of tubular reabsorption of Mg by the action of glycosuria and hyperglycemia [35].…”

Section: Shalanyuy and Mosessupporting

confidence: 91%

Serum Lipid and Trace Mineral Profiles Among Type 2 Diabetics and Hypertensive Diabetics at the Bamenda Regional Hospital

SHALANYUY

Samje

2019

Asian J Pharm Clin Res

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Objective: Diabetes mellitus has become a clinical condition of public health importance, especially in developing countries due to its high mortality and morbidity. The aim of this study was to measure and compare the lipid and serum trace mineral profile among type 2 diabetics and hypertensive diabetics with controls. Methods: This cross-sectional study was carried out at the Regional Hospital, Bamenda, involving 50 diabetic normotensives, 50 hypertensive diabetics, and 50 normal recruited subjects. Serum levels of lipids and minerals were determined using standard methods. Results: Of the four trace elements assessed, except for copper (Cu) whose mean values in diabetics were abnormally increased (p=0.01), zinc (Zn), magnesium (Mg), and chromium (Cr) showed significantly decreased mean values in diabetics compared to the controls (p<0.05). The mean levels of these trace elements were also significantly reduced in hypertensive diabetic patients (p<0.05). In diabetics, there was no significant difference in the lipid levels. However, only total cholesterol (TC) and low-density lipoprotein mean values were significantly higher in hypertensive diabetic patients compared to the normal controls. There was also a positive significant correlation between the body mass index and Cr (r=+0.3, p=0.045) in diabetics. Conclusion: This study saw statistically significant differences in the serum lipid and trace element levels between diabetics, hypertensive diabetics, and controls: With diabetic and diabetic hypertensive patients having higher serum Cu levels and decreased serum Mg, Zn, and Cr levels compared to the normal controls. The lipid profile levels in diabetics and hypertensive diabetics were not significant differences within the study groups for all lipid profile estimations except for TC and LDL which were significantly higher only in hypertensive diabetic patients.

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“…No significant difference in serum magnesium among participants who attained and did not attain ADA glycaemic goal for FPG was observed questioning the relationship between glycaemic control and serum magnesium. 52 Significant association of serum magnesium with serum LDL and TC was observed with lower Odds of encountering hypomagnesaemia among participants with normal serum LDL and higher Odds of encountering hypomagnesaemia among participants with elevated TC. Magnesium supplementation in diet reduces TC, LDL-C and elevates serum HDL-C 53 but the association of serum magnesium with HDL-C was not observed.…”

Section: Discussionmentioning

confidence: 88%

“…The median age of diabetic participants were 53.5 (45)(46)(47)(48)(49)(50)(51)(52)(53)(54)(55)(56)(57)(58)(59)(60) years. 25 (83.3%) diabetics were females.…”

Section: Resultsmentioning

confidence: 99%

Case Control Study Evaluating the Association of Serum Magnesium With Diabetes Mellitus, Its Microvascular Complications and Serum Lipid Profile

Mukker¹,

Narayanan²

2019

jebmh

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BACKGROUNDWe wanted to evaluate the association of serum magnesium with diabetes mellitus and serum lipid profile and its microvascular complications.METHODS 90 participants (30 DM with microvascular complications, 30 DM without microvascular complications and 30 controls) aged 40 to 80 years were enrolled in the present cross-sectional study. Hypertensives, alcoholics, participants with diarrhoea and history of drug use (digoxin, corticosteroids etc.) were excluded. History, physical examination findings, biochemical parameters, ECG findings, nerve conduction study and ophthalmoscopic examination findings were collected. Tests of significance were ANOVA, independent sample 't' test, Kruskal Wallis test, Mann Whitney U test and Chi-square test. p<0.05 was considered statistically significant. RESULTSSignificantly lower serum magnesium was observed among participants with neuropathy (p<0.001), nephropathy (p<0.001) and retinopathy (p<0.001) and among diabetics without family history of DM (p=0.02). No association of ADA glycaemic goal and serum magnesium was observed. Significant association of serum magnesium with TC (p<0.001; OR: 9.5, 95% CI 2.7-33.9), serum LDL (p<0.001; OR: 0.01, 95% CI 0.002-0.1), retinopathy (p=0.03; OR: 0.2, 95% CI 0.04-0.9), nephropathy (p=0.001; OR: 0.1, 95% CI 0.03-0.4) was observed. CONCLUSIONSThere is a linear relationship between duration of DM and serum magnesium, severe hypomagnesaemia among participants with microvascular complications. Participants with hypomagnesaemia had significantly higher blood glucose, urea, serum creatinine, total cholesterol, low density lipoprotein and triglycerides. No association between ADA glycaemic control and serum magnesium was observed. Further studies are required to evaluate the pathophysiological role of magnesium in DM and diabetes dyslipidaemia.Financial or Other, Competing Interest: None.

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Association of serum magnesium level with poor glycemic control and renal functions in Nepalese patients with type 2 diabetes mellitus

Cited by 24 publications

References 34 publications

Serum Magnesium Level of Newly Detected Patients with Glucose Intolerance and Its Comparison with Serum Magnesium Level of Age and Sex Matched Healthy Volunteers

Serum Magnesium Level of Newly Detected Patients with Glucose Intolerance and Its Comparison with Serum Magnesium Level of Age and Sex Matched Healthy Volunteers

Serum Lipid and Trace Mineral Profiles Among Type 2 Diabetics and Hypertensive Diabetics at the Bamenda Regional Hospital

Case Control Study Evaluating the Association of Serum Magnesium With Diabetes Mellitus, Its Microvascular Complications and Serum Lipid Profile

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