Association of serum IL-18 with protein-energy wasting in end-stage renal disease patients on haemodialysis

Bi, Xiao; Chu, Mingzi; Ai, Honglan; Hu, Chun; Ding, Wei

doi:10.1007/s11255-019-02167-5

Cited by 13 publications

(9 citation statements)

References 31 publications

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“…Preview studies have reported that aging was associated with the prevalence of CKD (56.4 years old in Henan China Duan et al., 2019 and 57.2 years old in north Sri Lanka Ranasinghe et al., 2019), and this aging trend was also recognized in our study (the average age was 59.6 years old). Forty (62.5%) patients were diagnosed with PEW in the present study, which was higher than similar studies for the influence of aging (Bi et al., 2019; Gracia‐Iguacel et al., 2019; Hara et al., 2018). Many indicators could be used for determining PEW, such as the ISRNM and ESPEN definitions we refer to.…”

Section: Discussioncontrasting

confidence: 76%

Predicational ability of phase angle on protein energy wasting in kidney disease patients with renal replacement therapy: A cross‐sectional study

Zhou

Yao

Pan

et al. 2021

Food Science & Nutrition

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Objective To investigate the ability of phase angle (PA) and body composition for predicting protein energy wasting (PEW) in renal replacement therapy (RRT) patients. Methods Renal replacement therapy (RRT) patients were enrolled in this study. Body composition was measured by direct segmental multi‐frequency biolectrical impedance analysis method (DSM‐BIA); phase angle (PA), fat‐free mass (FFM), fat mass (FM), mid‐arm circumference (MAC), WC (waist circumference), and ECW/TBW (extracellular water/total body water) were obtained. Biochemicals (serum albumin, triglyceride, and cholesterol) were tested. PEW patients were classified according to ISRNM (The International Society of Renal Nutrition and Metabolism) criteria. Cutoff value of PA and related variables was calculated by ROC analysis. The ability of body composition variables as indicators to predict PEW was evaluated. Results Sixty‐four patients were enrolled in this study. Thirty‐three patients (52.6%) were males, and forty (62.5%) patients were diagnosed with PEW. The ROC curve showed that the optimal cutoff values of PA, FFMI (fat‐free mass index), MAC, WC, and BMI for PEW risk were 4.45°, 16.71, 29.7 cm, 86.4 cm, and 21.1 kg/m2, respectively. These indicators showed significant association with PEW; meanwhile, the PA and MAC can be used as the predictors for PEW with OR 6.333 (95% CI, 1.956–20.505) and 3.267 (95% CI, 1.136–9.394), respectively. Both groups have a lower BUN/Cr ratio (<20). Conclusion In the RRT patients, over than 60% patients were diagnosed with PEW. PA, MAC, and other body composition can be used as the independent indicators for predicting PEW in renal replacement therapy kidney disease patients.

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Section: Discussioncontrasting

confidence: 76%

Predicational ability of phase angle on protein energy wasting in kidney disease patients with renal replacement therapy: A cross‐sectional study

Zhou

Yao

Pan

et al. 2021

Food Science & Nutrition

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“…Higher concentrations of IL-1β predicted hypotensive episodes during the hemodialysis procedure in ESKD [ 348 ]. Circulating protein concentrations of IL-18 were higher in HD patients with protein-energy wasting compared to HD patients without this condition [ 349 ] and predicted major adverse cardiovascular events [ 350 ], cardiocerebral vascular events [ 351 ], and, in children, left ventricular hypertrophy [ 352 ] among ESKD patients with HD therapy. In post-myocardial infarction patients with moderate CKD and increased high-sensitivity C-reactive protein concentrations, the inhibition of IL-1β with the monoclonal antibody canakinumab reduced major adverse cardiovascular events [ 353 ].…”

Section: Inflammasome Components In Ckdmentioning

confidence: 99%

Involvement of Inflammasome Components in Kidney Disease

et al. 2022

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Inflammasomes are multiprotein complexes with an important role in the innate immune response. Canonical activation of inflammasomes results in caspase-1 activation and maturation of cytokines interleukin-1β and -18. These cytokines can elicit their effects through receptor activation, both locally within a certain tissue and systemically. Animal models of kidney diseases have shown inflammasome involvement in inflammation, pyroptosis and fibrosis. In particular, the inflammasome component nucleotide-binding domain-like receptor family pyrin domain containing 3 (NLRP3) and related canonical mechanisms have been investigated. However, it has become increasingly clear that other inflammasome components are also of importance in kidney disease. Moreover, it is becoming obvious that the range of molecular interaction partners of inflammasome components in kidney diseases is wide. This review provides insights into these current areas of research, with special emphasis on the interaction of inflammasome components and redox signalling, endoplasmic reticulum stress, and mitochondrial function. We present our findings separately for acute kidney injury and chronic kidney disease. As we strictly divided the results into preclinical and clinical data, this review enables comparison of results from those complementary research specialities. However, it also reveals that knowledge gaps exist, especially in clinical acute kidney injury inflammasome research. Furthermore, patient comorbidities and treatments seem important drivers of inflammasome component alterations in human kidney disease.

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“…Currently, several SIR markers can be identified, the concentration of which in the blood is strongly linked to the dynamics of chronic renal failure in general. These factors include accumulation in the blood [ 177 , 178 , 179 , 180 , 181 , 182 , 183 , 184 , 185 ] of the following: various ROS; proinflammatory cytokines: TNF-α, IL-6, and IL-18; chemokines: IL-8 (CXCL8), IL-34, SDF1α (CXCL12), MCP-1 (CCL2), and MIP-1β (CCL4); growth factors: GM-CSF (granulocyte-macrophage colony-stimulating factor), FGF-23, and HGF (hepatocyte growth factor); soluble forms of receptors: sTNFR1 and sTNFR2, sCD40L, and sCD163 (SR-I3); cyclophilin A as an inducer of proinflammatory cytokines [ 186 ]. …”

Section: Systemic Inflammatory Processes In Esrdmentioning

confidence: 99%

The Pathogenesis of End-Stage Renal Disease from the Standpoint of the Theory of General Pathological Processes of Inflammation

Гусев

Соломатина

Zhuravleva

et al. 2021

IJMS

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Chronic kidney disease can progress to end-stage chronic renal disease (ESRD), which requires the use of replacement therapy (dialysis or kidney transplant) in life-threatening conditions. In ESRD, irreversible changes in the kidneys are associated with systemic changes of proinflammatory nature and dysfunctions of internal organs, skeletal muscles, and integumentary tissues. The common components of ESRD pathogenesis, regardless of the initial nosology, are (1) local (in the kidneys) and systemic chronic low-grade inflammation (ChLGI) as a risk factor for diabetic kidney disease and its progression to ESRD, (2) inflammation of the classical type characteristic of primary and secondary autoimmune glomerulonephritis and infectious recurrent pyelonephritis, as well as immune reactions in kidney allograft rejection, and (3) chronic systemic inflammation (ChSI), pathogenetically characterized by latent microcirculatory disorders and manifestations of paracoagulation. The development of ChSI is closely associated with programmed hemodialysis in ESRD, as well as with the systemic autoimmune process. Consideration of ESRD pathogenesis from the standpoint of the theory of general pathological processes opens up the scope not only for particular but also for universal approaches to conducting pathogenetic therapies and diagnosing and predicting systemic complications in severe nephropathies.

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Association of serum IL-18 with protein-energy wasting in end-stage renal disease patients on haemodialysis

Cited by 13 publications

References 31 publications

Predicational ability of phase angle on protein energy wasting in kidney disease patients with renal replacement therapy: A cross‐sectional study

Predicational ability of phase angle on protein energy wasting in kidney disease patients with renal replacement therapy: A cross‐sectional study

Involvement of Inflammasome Components in Kidney Disease

The Pathogenesis of End-Stage Renal Disease from the Standpoint of the Theory of General Pathological Processes of Inflammation

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