Association of serum gamma-glutamyl transferase with treatment outcome in chronic hepatitis B patients

Huang, Rui; Yang, Chenchen; Liu, Yong; Xia, Juan; Su, Ran; Xiong, Ye; Wang, Guiyang; Sun, Zhen; Yan, Xiaomin; Lu, Shan; Wu, Chao

doi:10.3748/wjg.v21.i34.9957

Cited by 14 publications

(17 citation statements)

References 44 publications

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“…First, elevated GGT has been shown to be revealed and detected dramatically with the progression of mortality in liver diseases, cancer, and diabetes in the United States. Second, the serum GGT level is elevated in patients with chronic hepatitis C. [41] The phylogenetic tree represented in Figure 5 appeared that these samples in each branch have the same DNA sequences. It means that the virus had been transmitted most probably through blood transfusion as a result of the compatibility of DNA sequences between donors and thalassemia patients and D sequence of the coinfected persons with SEN-V D and H is the same sequence of D genotype of the SEN-V-D infected person.…”

Section: Discussionmentioning

confidence: 99%

Molecular and Genotypic Study of Senv-D Virus Coinfection in Β-Thalassemic Patients Infected With the Hepatitis C Virus in Iraq

Al-Ouqaili¹

2018

IJGP

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Objective and Background: SEN virus has identified as a putative new hepatitis virus coinfected with hepatitis C in thalassemic patients. The study aimed to measure viremia with SEN virus among thalassemic patients infected and non-infected with hepatitis C virus (HCV). Further, to detect the genotype D and the genetic alterations in the internal transcribed spacer domains/regions of SENV-D genotypes. Patients and Methods: A total of 200 β-thalassemic patients were included. HCV-RNA and SEN-DNA are extracting automatically. Then, amplification for SEN-DNA by conventional polymerase chain reaction (PCR) was achieved. Furthermore, HCV-RNA was amplified using real-time PCR (RT-PCR). Sequencing analysis was also done for 14 samples of amplified SENV-D DNA. Results: Out of 100 positive ELISA-anti-HCV antibodies which were definite for RT-PCR, the mean viral load in these patients was 545806 ± 1,009,799 IU/ml (1,997,176 ±3,802,206) copies/ml. There was a significant increase in SENV-D in thalassemia patients without HCV infection (59%) than those in thalassemia patients with HCV infection (44%) and healthy subjects (7%). In a sequencing study, 11 samples were infected with D genotype only while three from thalassemia patients group were coinfected with D and H genotypes. Conclusions: The occurrence rate of SEN-V DNA in thalassemia patients is very high in Iraq. Further, SEN-V-D genotype is more prevalent, and the sequences of SEN-V-D nucleotides in persons with coinfection are the same sequences of persons that have an infection with SEN-V-D alone. The most countries which have similar sequences to Iraqi SENV-D genotype sequence are Iran followed by China, Japan, Brazil, and the United States of America.

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Section: Discussionmentioning

confidence: 99%

Molecular and Genotypic Study of Senv-D Virus Coinfection in Β-Thalassemic Patients Infected With the Hepatitis C Virus in Iraq

Al-Ouqaili¹

2018

IJGP

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“…However, the biological relevance of gamma‐GT as a biomarker in overall disease outcome and in particular in viral hepatitis has become increasingly substantiated in recent years. Elevated gamma‐GT levels are associated with an increased overall mortality . They are associated with treatment‐induced HBeAg seroconversion in hepatitis B patients and with sustained viral response after interferon treatment in hepatitis C patients .…”

Section: Discussionmentioning

confidence: 99%

“…Elevated gamma‐GT levels are associated with an increased overall mortality . They are associated with treatment‐induced HBeAg seroconversion in hepatitis B patients and with sustained viral response after interferon treatment in hepatitis C patients . In addition, gamma‐GT levels have been suggested to predict significant fibrosis in hepatitis B patients .…”

Section: Discussionmentioning

confidence: 99%

“…[32][33][34][35][36] They are associated with treatment-induced HBeAg seroconversion in hepatitis B patients and with sustained viral response after interferon treatment in hepatitis C patients. 35,37,38 In addition, gamma-GT levels have been suggested to predict significant fibrosis in hepatitis B patients. 39 We carefully assessed the predictive value of FIB-4, APRI, GPR and histological fibrosis stage.…”

Section: Discussionmentioning

confidence: 99%

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Stopping nucleos(t)ide analogue treatment in Caucasian hepatitis B patients after HBeAg seroconversion is associated with high relapse rates and fatal outcomes

Hees¹,

Bourgeois²,

Vlierberghe³

et al. 2018

Aliment Pharmacol Ther

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SummaryBackgroundStopping nucleos(t)ide analogues (NA) after hepatitis B e antigen (HBeAg) seroconversion is associated with high relapse rates in Asian patients, but data in Caucasian cohorts are scarce. Clinical course, outcomes and immunological aspects of chronic hepatitis B infections differ substantially between distinct ethnicities.AimThe aim of this study was to determine relapse rates, factors predicting relapse and clinical outcomes after nucleos(t)ide analogue cessation in a large, predominantly Caucasian cohort of chronic hepatitis B patients with nucleos(t)ide analogue‐induced HBeAg seroconversion.MethodsThis is a nationwide observational cohort study including HBeAg positive, mono‐infected chronic hepatitis B patients with nucleos(t)ide analogue‐induced HBeAg seroconversion from 18 centres in Belgium.ResultsA total of 98 patients with nucleo(s)tide analogue‐induced HBeAg seroconversion were included in the study. Of the 62 patients who stopped treatment after a median consolidation treatment of 8 months, 30 relapsed. Higher gamma‐glutamyl transferase levels at both treatment initiation (HR 1.004; P = 0.001 per unit increment) and HBeAg seroconversion (HR 1.006; P = 0.013 per unit increment) were associated with an increased risk of clinically significant relapse in a multivariate Cox regression model. Treatment cessation led to liver‐related death in 2 patients, of whom one showed a severe flare. Of the patients who continued treatment after HBeAg seroconversion, none relapsed or developed severe hepatic outcomes.ConclusionTreatment withdrawal in Caucasian chronic hepatitis B patients after nucleos(t)ide analogue‐induced HBeAg seroconversion results in viral relapses in more than half of patients with potential fatal outcomes. These real‐world data further lend support to preferentially continue NA treatment after HBeAg seroconversion until HBsAg loss.

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“…Specifically, GGT levels are reportedly associated with the presence of HCC in patients with HCV infections [19]. Therefore, GGT levels might be predictive of HCC development in patients without cirrhosis, even after successful HCV eradication [20]. These observations suggest that a similar correlation might exist for patients with elevated GGT levels associated with SENV-H infections.…”

Section: Parametermentioning

confidence: 85%

SEN virus genotype H distribution in β-thalassemic patients and in healthy donors in Iraq: Molecular and physiological study

2020

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The SEN virus (SENV) has been linked to transfusion-associated non-A-E hepatitis; however, information regarding SENV infections in patients with thalassemia, particularly in those with hepatitis virus co-infections, remains limited. This study investigated the frequency of SENV (genotypes D and H) infections in Iraqi patients with thalassemic patients infected and not infected with hepatitis C virus. The study involved 150 β-thalassemia patients (75 with HCV infections and 75 without) and 75 healthy blood donors. Patient levels of vitamins C and E, liver function markers, and glutathione peroxidase (GPX) were determined. Recovered viral nucleic acids were amplified using the conventional polymerase chain reaction (SENV DNA) or the real-time polymerase chain reaction (HCV RNA) techniques. Only 10% of healthy donors had evidence of SENV infection. Among patients with thalassemia, 80% and 77% of patients with and without concurrent HCV infections, respectively, had SENV infections. DNA sequencing analyses were performed on blood samples obtained from 29 patients. Patients with thalassemia, particularly those with SENV infections, had higher levels of several enzymatic liver function markers and total serum bilirubin (P < 0.05) than did healthy blood donors. Among the examined liver function markers, only gamma-glutamyl transferase demonstrated significantly higher levels in HCV-negative patients infected with SENV-H than in those infected with SENV-D (P = 0.01). There were significantly lower vitamin C, vitamin E, and glutathione peroxidase levels in patients than in healthy donors (P < 0.05), but only glutathione peroxidase levels were significantly lower in HCV-negative thalassemia patients infected with SENV than in those without SENV infections (P = 0.04). The SENV-H genotype sequences were similar to the global standard genes in GenBank. These results broaden our understanding the nature of the SENV-H genotype and the differential role of SENV-H infections, compared to SENV-D infections, in patients with thalassemia, in Iraq.

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Association of serum gamma-glutamyl transferase with treatment outcome in chronic hepatitis B patients

Abstract: Serum GGT is significantly elevated in EPH and ENH patients and is a potential biomarker for the prediction of HBeAg seroconversion following NA therapy.

Cited by 14 publications

References 44 publications

Molecular and Genotypic Study of Senv-D Virus Coinfection in Β-Thalassemic Patients Infected With the Hepatitis C Virus in Iraq

Molecular and Genotypic Study of Senv-D Virus Coinfection in Β-Thalassemic Patients Infected With the Hepatitis C Virus in Iraq

Stopping nucleos(t)ide analogue treatment in Caucasian hepatitis B patients after HBeAg seroconversion is associated with high relapse rates and fatal outcomes

SEN virus genotype H distribution in β-thalassemic patients and in healthy donors in Iraq: Molecular and physiological study

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