Association of serum ferritin with insulin resistance in offsprings of type 2 diabetics

Khalil, Osama A.; Seliem, Fayroz O; Alnahal, Alsayed; Awad, Mohamed M; Sadek, Ayman Magd Eldin Mohammad; Fawzy, Mohamed S

doi:10.4103/ejim.ejim_70_17

Cited by 11 publications

(8 citation statements)

References 16 publications

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“…The plasma level generally reflects overall iron storage, with 1 ng of ferritin per ml indicating approximately 10 mg of total iron stores (12) . Pathways related to inflammation and autoimmunity impacted ferritin regulation, which affects ferritin content within cells, among these pathways, several pro-inflammatory cytokines (13) , It has been reported that fatal outcomes by COVID-19 are accompanied by cytokine storm syndrome, thereby it has been suggested that it cause disease severity (5) , Many individuals with diabetes exhibit elevated serum ferritin levels (14) , and it is known that they face a higher probability to experience serious complications from COVID-19 (8) . (15) , Also, Chen et al analyzed the clinical characteristics of 99 patients, in which 63 of them had serum ferritin way above the normal range (16) , Elevated ferritin levels were found also in autopsies of 12 patients whose cause of death was SARS-CoV-2 infection (17) .…”

Section: Resultsmentioning

confidence: 99%

Ferritin as a biomarker of infection in COVID-19 non-hospitalized patients

Yameny¹

2021

Journal of Bioscience and Applied Research

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Background: Serum ferritin is an iron storage protein with a primary role of regulating cellular oxygen metabolism, Ferritin has emerged as a key in the immune system, and its role as an acute phase reactant, recent studies have focused on the role of serum inflammatory markers that predict COVID-19. Patients and methods: This study included 210 non hospitalized patients with confirmed COVID-19 infection in Alexandria, Egypt, these study subjects were randomly selected irrespective of the age group and both genders were included, Assay procedure as manufactory instructions and Reagents of PerkinElmer Health sciences. Inc USA kit human ferritin enzyme immunoassay test catalog number 10601 was used. Results:The present study included patients aged from14 years to 75 years mean age was 44.5 ±30.5 who were confirmed to have Covid-19 based on real-time reverse transcription-polymerase chain reaction, the female gender was more frequent (n=132, 62.9%) than Male gender (n=78, 37.1%). This study reveals high serum ferritin level in 150 patients (71.4 %), which was a significant biomarker for COVID-19 diagnosis in nonhospitalized patients (Outpatients and patients under home observation), the p-value is .014738. Significant at p< .05. Conclusion and Recommendations: Serum ferritin level is a good biomarker of infection in COVID-19 non-hospitalized patients, many other studies revealed ferritin is a good marker for COVD-19 hospitalized patients, Increased ferritin levels could cause a cytokine storm by exerting direct immunosuppressive and pro-inflammatory effects, It has been reported that fatal outcomes by COVID-19 are accompanied by cytokine storm syndrome, Many individuals with diabetes and immunosuppressive diseases exhibit elevated serum ferritin levels, and it is known that they face a higher probability to experience serious complications from COVID-19 infection, so these patients must go to the medical laboratory for serum ferritin level analysis, to decrease ferritin levels might be the treatment with iron chelators. Deferoxamine, which was approved by the FDA, with decreasing dietary iron should be also considered as they have been shown to modify serum ferritin levels.

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Section: Resultsmentioning

confidence: 99%

Ferritin as a biomarker of infection in COVID-19 non-hospitalized patients

Yameny¹

2021

Journal of Bioscience and Applied Research

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“…Ferritin, which is regarded as a critical mediator in immune dysregulation, is linked to cytokine storm syndrome if present in excess. Raised ferritin level has been reported by several studies in COVID-19 patients [9,41]. Enhanced plasma creatinine values can act as an indicator of reduced excretion.…”

Section: Discussionmentioning

confidence: 84%

Hematological and inflammatory parameters in hospitalized patients with COVID‐19 infection in Chattogram, Bangladesh

Bulbul¹,

Uddin²,

Faiyaz³

et al. 2021

jrp

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COVID-19 emerged as a pandemic that is persisting with massive casualties around the globe. To ensure clinical management, changes in hematological parameters are routinely monitored and considered essential in patients with coronavirus disease 2019 (COVID-19) to measure the disease prognosis. This study aimed to recognize alterations in patients' hematological and inflammatory parameters with COVID-19. We obtained and analyzed data from 170 COVID-19 positive patients and 78 COVID-19 negative patients confirmed by qRT-PCR. The laboratory data included the hematological and inflammatory parameters of the selected patients. Compared with COVID-19 negative groups, COVID-19 patients had significantly higher levels of hematocrit (HCT) (p <0.01), mean platelets volume (MPV) (p <0.01), neutrophils (p <0.01), erythrocyte sedimentation rate (ESR) (p <0.0001), C-Reactive Protein (CRP) (p <0.0001), and significantly lower levels of Hemoglobin (Hb) (p <0.0001), lymphocytes (p <0.0001), monocytes (p <0.0001), eosinophils (p <0.01), basophils (p <0.05). This study also observed significantly increased levels of Hb, HCT, RBC, MCH, MCHC, monocytes, ferritin, and significantly decreased RDW-CV, platelets count, ESR in the COVID-19 male patients than the COVID-19 female patients. This study suggests that hematological and inflammatory parameters should be considered in the clinical management of COVID-19 patients.

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“…Ferritin, in particular under severe hyperferritinemia, is a key mediator of immune dysregulation through direct immune suppressive and pro-inflammatory effects, leading to cytokine storm. 42 Several studies suggest that increased levels of serum ferritin and other inflammatory markers in severe and critical patients as compared to mild and moderate patients. damage and increases the severity of infection.…”

Section: Discussionmentioning

confidence: 99%

Ferritin – The key model inflammatory marker in diabetic and non-diabetic COVID-19

et al. 2021

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Background: Diabetics exhibit elevated serum ferritin level when compared to non-diabetic counterpart, indicates impact of its association with coronavirus disease 2019 (COVID-19) infection and disease progression. Ferritin is a key mediator of immune dysregulation through direct immunosuppression contributing to cytokine storm resulting in fatal outcome in COVID-19. Aims and Objectives: This study aims to estimate serum ferritin in diabetic (cases) and non-diabetic (controls) COVID-19 patients and its correlation with their diabetic profile (FBS, PPBS, RBS, and HbA1C). Materials and Methods: A retrospective case–control study conducted at Rajarajeswari Medical College and Hospital, Bengaluru, for a period of 8 months among diabetic and non-diabetic COVID-19 patients. Results: The study population consisted of 957 individuals, out of them, 425 patients were type 2 diabetes mellitus and 532 were non-diabetic COVID-19-positive patients (controls). Diabetic profile parameters (FBS, PPBS, RBS, and HbA1c) and serum ferritin were significantly (P<0.05) high in cases as compared to controls. Among diabetic COVID-19, the glycated hemoglobin and serum ferritin showed a significantly positive correlation (r=0.55) with serum ferritin (mean=648.98±320.48). Conclusion: Hyperferritinemia is more prevalent in diabetic COVID-19 individuals. Serum ferritin can be considered as a valuable biomarker to screen the diabetic and non-diabetic for the presence of hyperinflammation and to predict severity of COVID-19 infection so that it will help the clinician for proper management.

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Association of serum ferritin with insulin resistance in offsprings of type 2 diabetics

Cited by 11 publications

References 16 publications

Ferritin as a biomarker of infection in COVID-19 non-hospitalized patients

Ferritin as a biomarker of infection in COVID-19 non-hospitalized patients

Hematological and inflammatory parameters in hospitalized patients with COVID‐19 infection in Chattogram, Bangladesh

Ferritin – The key model inflammatory marker in diabetic and non-diabetic COVID-19

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