Association of Serum Electrolytes and Urea Levels with Cardiac Markers in Acute Myocardial Infarction

Mudaraddi, Rakesh; Kulkarni, Shrirang Vasant; Trivedi, Dhiraj J.; Patil, Vidya Shankargouda; Kamble, Pramod

doi:10.5958/2394-6377.2015.00009.x

Cited by 4 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similarly, the significant decreased level of potassium in AMI subjects, as observed in our study, is in line with the studies done by Mati et al 8 , Mudaraddi et al 10 and Mandole et al 11 . The main reason for hypokalemia in patients of AMI is most likely an activation of the sympathetic nervous system leading to an influx of potassium from the extracellular to the intracellular body fluid compartment 16 .…”

Section: Discussionsupporting

confidence: 94%

“…In this study, we found significantly decreased levels of sodium and potassium in AMI patients as compared to that of age and gender matched control subjects. The significant decreased level of sodium in AMI patients is in accordance with the findings of Mati et al 8 , Mudaraddi et al 10 and Mandole et al 11 . In acute myocardial infarction, there occurs non osmotic release of vasopressin due to the acute development of left ventricular dysfunction in response to pain, nausea, and major stress, or in response to the administration of analgesics and diuretics.…”

Section: Discussionsupporting

confidence: 91%

See 1 more Smart Citation

Electrolyte Imbalance in Patients of Acute Myocardial Infarction: A Study from Central India

Rathore¹

2018

jmscr

View full text Add to dashboard Cite

Background: Acute myocardial infarction is one the manifestations of coronary heart disease, leading to morbidity and mortality. Electrolytes such as sodium and potassium are considered to be major determinants of electrophysiological properties of myocardial membrane and their imbalance after an episode of AMI is common. Hence, the present study was planned with the aim to evaluate serum sodium and potassium in patients of AMI. Materials and Methods: The present study included 50 patients of AMI and 50 normal healthy individuals as controls. In all the subjects, sodium and potassium were measured by ion selective electrolyte analyzer. Results: Both sodium and potassium were significantly reduced in patients of AMI as compared to controls (131.48±6.31 meq/L vs. 139.32±3.09 meq/L, p<0.001 and 3.57±0.81 meq/L vs. 4.36±0.45 meq/L, p<0.001, respectively). Conclusion:In conclusion, electrolytes such as sodium and potassium could be estimated in AMI subjects, which will provide additional information with regard to treatment as well as prognosis.

show abstract

Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 91%

Electrolyte Imbalance in Patients of Acute Myocardial Infarction: A Study from Central India

Rathore¹

2018

jmscr

View full text Add to dashboard Cite

show abstract

“…Changes in its concentration alter the irritability and rhythm of the myocardium. This is slightly different from the research by Mudaraddi (2015), which is from 60 patients with acute myocardial infarction, the average sodium level is 132.5 mEq/L and the average potassium level is 3.88 mEq/L. The average sodium level is below the normal value but the average potassium level is still within the normal range.…”

Section: Resultscontrasting

confidence: 79%

Correlation Between Troponin I Levels and Electrolytes of Sodium and Potassium in Acute Coronary Syndrome Patients at Budhi Asih Hospital

Prasetyorini

Lestari

Farhah

et al. 2022

IJSOC

View full text Add to dashboard Cite

Acute Coronary Syndrome (ACS) is one of the clinical manifestations of coronary heart disease that most often causes of death. A sensitive laboratory examination to assess the presence of signs of myocardial infarction such as troponin I is used to diagnose ACS. Electrolyte levels can also be impaired in myocardial infarction. Electrolyte imbalance in the blood can affect the conduction and contractility of the heart, especially sodium and potassium which are needed to produce activation of the heart muscle. The aim of this study was to determine the correlation between troponin I levels and sodium and potassium levels of serum in acute coronary syndrome patients with diabetes mellitus. The research design was used a cross sectional analytical observation with secondary data. This study was used the Spearman correlation test with an alpha value of 0.05. The data were taken from the medical records section of Budhi Asih Hospital. The samples were used 65 data of patients. The results showed that there was a correlation between troponin I levels and sodium with a p value 0.001 (p < 0.05), getting a fairly strong closeness level (r = -0.390) and negative direction. Likewise, the levels of troponin I with potassium showed a p value 0.000 (p < 0.05), getting a fairly strong level of closeness (r = -0.487) and a negative direction. From this study, it can be concluded that there was a relationship between troponin I levels with sodium and potassium with a negative correlation direction which indicates that the higher troponin I levels, so the lower the sodium and potassium levels. Electrolyte examination, especially sodium and potassium, is important to help diagnose acute coronary syndrome in knowing the balance of body fluids so as to prevent death.

show abstract

“…There was no significant change in serum potassium and sodium levels in the mice treated with Sora-MNC compared to control group (Additional file 1 : Fig. S13), showing no sign of electrolyte disturbance and cardiac toxicity [ 62 ]. Collectively, these results demonstrated superior therapeutic efficacy and safety of Sora-MNC over free sorafenib formulation in AML-PDX model.…”

Section: Resultsmentioning

confidence: 99%

Bone marrow-targetable Green Tea Catechin-Based Micellar Nanocomplex for synergistic therapy of Acute myeloid leukemia

et al. 2022

View full text Add to dashboard Cite

Background Currently available anti-leukemia drugs have shown limited success in the treatment of acute myeloid leukemia (AML) due to their poor access to bone marrow niche supporting leukemic cell proliferation. Results Herein, we report a bone marrow-targetable green tea catechin-based micellar nanocomplex for synergistic AML therapy. The nanocomplex was found to synergistically amplify the anti-leukemic potency of sorafenib via selective disruption of pro-survival mTOR signaling. In vivo biodistribution study demonstrated about 11-fold greater bone marrow accumulation of the nanocomplex compared to free sorafenib. In AML patient-derived xenograft (AML-PDX) mouse model, administration of the nanocomplex effectively eradicated bone marrow-residing leukemic blasts and improved survival rates without noticeable off-target toxicity. Conclusion This study may provide insights into the rational design of nanomedicine platforms enabling bone marrow-targeted delivery of therapeutic agents for the treatment of AML and other bone marrow diseases. Graphical Abstract

show abstract

Association of Serum Electrolytes and Urea Levels with Cardiac Markers in Acute Myocardial Infarction

Cited by 4 publications

References 0 publications

Electrolyte Imbalance in Patients of Acute Myocardial Infarction: A Study from Central India

Electrolyte Imbalance in Patients of Acute Myocardial Infarction: A Study from Central India

Correlation Between Troponin I Levels and Electrolytes of Sodium and Potassium in Acute Coronary Syndrome Patients at Budhi Asih Hospital

Bone marrow-targetable Green Tea Catechin-Based Micellar Nanocomplex for synergistic therapy of Acute myeloid leukemia

Contact Info

Product

Resources

About