Association of Serum Cholesterol Efflux Capacity With Mortality in Patients With ST-Segment Elevation Myocardial Infarction

Guérin, Maryse; Silvain, Johanne; Gall, Julie; Darabi, Maryam; Berthet, Myriam; Frisdal, Éric; Hauguel-Moreau, Marie; Zeitouni, Michel; Kernéis, Mathieu; Lattuca, Benoît; Brugier, Delphine; Collet, Jean‐Philippe; Lesnik, Philippe; Montalescot, Gilles

doi:10.1016/j.jacc.2018.09.080

Cited by 61 publications

(44 citation statements)

References 29 publications

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“…We also found that combination of cholesterol efflux capacity and antioxidative activity strengthened the probability of ACS prediction. CEC, which represents HDL's ability to prevent the formation of macrophage foam cells by removing excess cholesterol from macrophages, rather than HDL cholesterol levels, has been shown to have significant negative correlation with atherosclerotic burden [11,12]. Our results demonstrate that HDL from ACS patients had lower ability to mediate cholesterol efflux from lipid laden macrophages compared to HDL from healthy subjects.…”

Section: Discussionmentioning

confidence: 69%

HDL functions and their interaction in patients of ST Elevation MI Acute Coronary Syndrome: a case control study

Thakkar¹,

Vincent²,

Roy³

et al. 2020

Preprint

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Background: Recent studies emphasize the importance of HDL function over HDL cholesterol measurement, as an important risk for cardiovascular diseases (CVD). We compared the HDL function of patients with Acute Coronary Syndrome (ACS) and healthy controls. Methods:We measured cholesterol efflux capacity of HDL using THP-1 macrophages labelled with fluorescently tagged (BODIPY) cholesterol. Paraoxonase and arylesterase activity of PON1 enzyme were assessed by spectrophotometric methods. Results: We recruited 151 ACS patients and 110 controls. The HDL function of all patients during acute phase and at six month follow-up was measured. The mean age of the patients and controls was 51.7 and 43.6 years respectively. The mean HDL cholesterol/apolipoprotein A-I levels (ratio) of patients during acute phase, follow-up and of controls were 40.2 mg/dl/ 112.5 mg/dl (ratio= 0.36), 38.3 mg/dl/ 127.2 mg/dl (ratio= 0.30) and 45.4 mg/dl/ 142.1 mg/dl (ratio=0.32) respectively. The cholesterol efflux capacity (CEC) of HDL was positively correlated with apolipoprotein A-I levels duringacute phase (r = 0.19, p = 0.019), follow-up (r = 0.26, p = 0.007) and of controls (r = 0.3, p = 0.0012) but not with HDL-C levels (acute phase: r = 0.07, p = 0.47; follow-up: r = 0.1 , p = 0.2; control: r = 0.02, p = 0.82). Higher levels of cholesterol efflux capacity, PON1 activity and apolipoprotein A-I were associated with lower odds of development of ACS. We also observed that low CEC is associated with higher odds of having ACS if PON1 activity of HDL is also low and vice versa.Conclusion: ACS is associated with reduced HDL functions which improves at follow-up. The predicted probability of ACS depends upon individual HDL functions and the interactions between them.

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Section: Discussionmentioning

confidence: 69%

HDL functions and their interaction in patients of ST Elevation MI Acute Coronary Syndrome: a case control study

Thakkar¹,

Vincent²,

Roy³

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 69%

HDL functions and their interaction in patients with ST elevation myocardial infarction: a case control study

et al. 2020

View full text Add to dashboard Cite

Background: Recent studies emphasize the importance of HDL function over HDL cholesterol measurement, as an important risk for cardiovascular diseases (CVD). We compared the HDL function of patients with acute coronary syndrome (ACS) and healthy controls. Methods: We measured cholesterol efflux capacity of HDL using THP-1 macrophages labelled with fluorescently tagged (BODIPY) cholesterol. PON1 activities toward paraoxon and phenyl acetate were assessed by spectrophotometric methods. Results:We recruited 150 ACS patients and 110 controls. The HDL function of all patients during acute phase and at six month follow-up was measured. The mean age of the patients and controls was 51.7 and 43.6 years respectively. The mean HDL cholesterol/apolipoprotein A-I levels (ratio) of patients during acute phase, follow-up and of controls were 40.2 mg/dl/ 112.5 mg/dl (ratio = 0.36), 38.3 mg/dl/ 127.2 mg/dl (ratio = 0.30) and 45.4 mg/dl/ 142.1 mg/dl (ratio = 0.32) respectively. The cholesterol efflux capacity (CEC) of HDL was positively correlated with apolipoprotein A-I levels during acute phase (r = 0.19, p = 0.019), follow-up (r = 0.26, p = 0.007) and of controls (r = 0.3, p = 0.0012) but not with HDL-C levels (acute phase: r = 0.07, p = 0.47; follow-up: r = 0.1, p = 0.2; control: r = 0.02, p = 0.82). Higher levels of cholesterol efflux capacity, PON1 activity and apolipoprotein A-I were associated with lower odds of development of ACS. We also observed that low CEC is associated with higher odds of having ACS if PON1 activity of HDL is also low and vice versa.Conclusion: ACS is associated with reduced HDL functions which improves at follow-up. The predicted probability of ACS depends upon individual HDL functions and the interactions between them.

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“…Four new biomarkers have been investigated in different trials in the setting of ACS: (i) galectin-3, implicated in fibrosis; (24) (ii) impaired endogenous fibrinolysis; (25) (iii) trimethyllysine and TMAO, gut-microbiota derived metabolite; (26) and (iv) serum cholesterol efflux capacity. (27) All these biomarkers were found to be independently associated with MACE at follow-up.…”

Section: Implantable Cardiac Alert Systemmentioning

confidence: 93%

The year in cardiology: acute coronary syndromes

Banning¹,

Crea

Lüscher

2020

SAHJ

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Association of Serum Cholesterol Efflux Capacity With Mortality in Patients With ST-Segment Elevation Myocardial Infarction

Cited by 61 publications

References 29 publications

HDL functions and their interaction in patients of ST Elevation MI Acute Coronary Syndrome: a case control study

HDL functions and their interaction in patients of ST Elevation MI Acute Coronary Syndrome: a case control study

HDL functions and their interaction in patients with ST elevation myocardial infarction: a case control study

The year in cardiology: acute coronary syndromes

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