Association of serum C-reactive protein (CRP) and D-dimer concentration on the severity of COVID-19 cases with or without diabetes: a systematic review and meta-analysis

Debi, Hoimonti; Itu, Zarin Tasnim; Amin, Mohammad Tohidul; Hussain, Fahad; Hossain, Mohammad Salim

doi:10.1080/17446651.2022.2002146

Cited by 13 publications

(13 citation statements)

References 79 publications

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“…Consequently, diabetes patients with COVID-19 infection experience more severe inflammatory responses and higher mortality rates 28 . There is a consensus that the prognosis of COVID-19 patients with diabetes is influenced by factors, such as CRP, D-dimer, lymphocyte count and other factors [29][30][31] . Our research also found a high In the present study, we observed that hsCRP levels are associated with the prognosis of COVID-19 patients with diabetes and showed a strong positive correlation with SAA levels.…”

Section: Discussionmentioning

confidence: 99%

Association of serum amyloid A and prognosis in people with diabetes and COVID‐19: A retrospective cohort study

Qu,

Liu,

Zhou

et al. 2023

J of Diabetes Invest

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Aims/IntroductionSerum amyloid A (SAA) is an acute phase reactive protein that plays a vital role in the early diagnosis, risk prediction, efficacy observation and prognosis evaluation of infectious diseases. This study aimed to assess the association between SAA levels and the prognosis of patients with coronavirus disease 2019 (COVID‐19) and diabetes.Materials and MethodsWe carried out this retrospective cohort study from March 2022 to May 2022. The population was stratified by tertiles of SAA levels: low (<8.5 mg/L), medium (8.5–36 mg/L) and high (>36 mg/L). The primary outcome was whether the patient developed severe COVID‐19, and secondary outcomes included the need for invasive mechanical ventilation and length of hospital stay. Logistic regression analyses were carried out to identify risk factors affecting the prognosis of patients with COVID‐19 and diabetes.ResultsWe analyzed 910 diabetes patients with COVID‐19. The median age of the patients was 69 years, and 52.3% were men. As SAA levels increased, the proportion of severe COVID‐19 (6.3% vs 7.3% vs 22.8%, P < 0.001) and the proportion of invasive mechanical ventilation also increased among the three groups. Patients with high SAA levels had a longer length of hospital stay compared with patients with medium SAA and low SAA levels. Univariate logistic regression analysis showed that SAA >36 mg/L further increased the odds ratio to 4.423 (P < 0.001) for the development of severe COVID‐19 compared with low SAA. Multivariate logistic regression analysis, adjusted for age and sex, confirmed that SAA >36 mg/L remained an independent risk factor for the development of severe COVID‐19 (adjusted odds ratio 3.038, P < 0.001).ConclusionsSAA levels are strongly associated with poor prognosis in patients with COVID‐19 and diabetes.

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Section: Discussionmentioning

confidence: 99%

Association of serum amyloid A and prognosis in people with diabetes and COVID‐19: A retrospective cohort study

Qu,

Liu,

Zhou

et al. 2023

J of Diabetes Invest

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“…Furthermore, CRP and WBC at admission were associated with factors affecting high SPPB recovery at discharge. Several systematic reviews have reported that higher CRP and D-dimer levels were associated with more severe COVID-19 [ 21 , 22 ], muscle weakness, and exercise intolerance [ 23 ]. It was recognized that the greater the severity of COVID-19, the higher the levels of inflammatory markers such as WBC, CRP, and severe respiratory failure, resulting in lower PaO 2 /FiO 2 .…”

Section: Discussionmentioning

confidence: 99%

Clinical Outcomes and Prevalence of Sarcopenia in Patients with Moderate to Severe COVID-19

Yamamoto

Sakai

Matsumori

et al. 2022

JCM

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Background: The purpose of this study was to investigate the effectiveness and clinical outcomes of inpatient rehabilitation for patients with severe COVID-19 in Japan. Methods: Patients with severe COVID-19 who underwent rehabilitation during hospitalization were included. The Medical Research Council (MRC) score and short physical performance battery (SPPB), such as physical function assessment and the intensive care unit (ICU) mobility scale, the functional status score for the ICU, and Barthel index as activities of daily living (ADLs) were evaluated at admission and discharge or transfer from the hospital. The correlation between SPPB at discharge and each factor at admission were also analyzed. Furthermore, the prevalence of sarcopenia was evaluated by defining SPPB of <9 points at discharge as sarcopenia. Results: The median age of the total of 23 patients was 59 years (interquartile range (IQR): 47–67), 73.9% were male, and the median PaO2/FiO2 at admission was 172.0 (IQR: 123.0–209.0). All physical function and ADL parameters were significantly improved from the time of admission to discharge (p = 0.014 for the MRC score and p < 0.001 for all others). Moreover, SPPB at discharge significantly correlated with WBC (Spearman’s rho = −0.473, p = 0.041), C-reactive protein (Spearman’s rho = −0.468, p = 0.044), and exhibited a significant trend with PaO2/FiO2 (Spearman’s rho = 0.429, p = 0.067) and age (Spearman’s rho = 0.409, p = 0.083). Although the median Barthel index at discharge was 90 points, 47% of patients had sarcopenia as defined by an SPPB of <9 points. Conclusions: Early rehabilitation for patients with severe COVID-19 improved physical function and ADLs during hospitalization. However, 47% of patients had the same level of sarcopenia at discharge.

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“…Other research indicated that the blood CRP and D-Dimer concentrations (for diabetic patients) were favorably connected with the age of COVID-19 patients; however, no significant correlation was observed when comparing the prevalence of COVID-19 diseases by geographical region. [35]. Milenkovic's (2022) study found that substantial abnormalities of laboratory parameters were found in patients with COVID-19 who were being treated in the intensive care unit.…”

Section: B) Comparison Of D Dimer and Crp Among Studied Groupsmentioning

confidence: 99%

Clinical Features of COVID-19 Patients in Thi-Qar Province

Akram¹,

Mahdi²,

Alsaimary³

2023

jsci

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Coronavirus disease–2019 (COVID-19) was detected in Wuhan, China, in December 2019, resulting in a 2% fatality rate. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the virus that causes this illness, and it is a newly discovered zoonotic strain.TLRs, which identify microbial components originating from invading pathogens, are implicated in the activation of innate responses to SARS-CoV-2 infection as well as the hyperinflammatory phenotype of COVID-19. Aim: Determining the most common clinical factors in people with Covid and adopting them as the initial clinical diagnosis. To reduce the risk of disease. Results: The highest age group of patients with covid_19 was (45-54 years) were 26 (29.5%) of all study patients. The most frequent symptom was fever (82.9%), and the least was diarrhea (21.6%). The study found no significant positive effect on smoking and non-smokers.

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Association of serum C-reactive protein (CRP) and D-dimer concentration on the severity of COVID-19 cases with or without diabetes: a systematic review and meta-analysis

Cited by 13 publications

References 79 publications

Association of serum amyloid A and prognosis in people with diabetes and COVID‐19: A retrospective cohort study

Association of serum amyloid A and prognosis in people with diabetes and COVID‐19: A retrospective cohort study

Clinical Outcomes and Prevalence of Sarcopenia in Patients with Moderate to Severe COVID-19

Clinical Features of COVID-19 Patients in Thi-Qar Province

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