Association of Serum Biomarkers and Cardiac Inflammation in Patients With Atrial Fibrillation: Identification by Positron Emission Tomography

Abstract

Background: Peripheral biomarkers may be affected by various factors, their reliability in reflecting local cardiac inflammatory status in patients with atrial fibrillation (AF) needs further exploration. This prospective study was aimed to investigate the relationship between circulating biomarkers and local cardiac inflammation measured by epicardial adipose tissue (EAT) activity via18F-fluorodeoxyglucose (FDG) imaging in AF patients.Methods: From 2017 to 2018, 83 AF patients [43 persistent AF (PsAF) and 40 paroxysmal AF (PAF)] referred for radiofrequency catheter ablation (RFCA) were recruited. Pre- and post-RFCA blood samples were collected to measure IL-6, IL-8, IL-10, IL-18, TNF-α, Hsp27, Hsp60, Hsp70, PDGF-BB, MMP-2, MMP-9, MPO, TGF-β1, Gal-3, and sST2. Pre-RFCA FDG images were obtained to assess EAT activity. Sixty-seven patients (35 PAF and 32 PsAF) received RFCA were regularly followed for 27 (24, 29) months.Results: Higher hsCRP and IL-6 and lower TGF-β1 were demonstrated in PsAF patients compared with PAF patients. Multivariate logistic regression analysis demonstrated that Gal-3 (OR: 1.221, 95% CI: 1.024–1.456, P = 0.026) and MPO (OR: 1.002, 95% CI: 1.001–1.003, P = 0.027) were independently correlated with EAT activity. The percentage decrease of Hsp60 linearly correlated with that of EAT activity post-RFCA (Spearman rs = 0.455, P = 0.019). Seventeen patients (10 PsAF and 7 PAF) had AF recurrence, but none of the selected biomarkers were predictive of post-RFCA recurrence.Conclusion: Our findings demonstrated that in patients with AF, Gal-3 correlated with local cardiac inflammation, and Hsp60 was associated with the alleviation of cardiac inflammation after RFCA.

Association between triglyceride-glucose index and atrial fibrillation: A retrospective observational study

“…The inclusion criteria were as follows ( 1 ): an ECG-confirmed diagnosis of AF ( 2 ); aged >18 years ( 3 ); complete clinical data. The exclusion criteria are as follows ( 16 – 18 ) ( 1 ): structural heart diseases and ischemia induced AF, such as myocardial infarction, decompensated heart failure, severe valvular heart disease, rheumatic heart disease ( 2 ); diagnosed with AF due to a reversible cause, such as acute thyrotoxicosis, pulmonary embolism, or postoperative status, solitary atrial flutter without AF ( 3 ); previous diagnosis of severe kidney or liver disease, recent infection, active inflammatory disorder or rheumatologic diseases that might influence IR or the TyG index. In addition, 179 age- and gender-matched subjects without AF who were hospitalized in the department during the same time period were randomly sampled and enrolled as the control group.…”

The relationship between right atrial wall inflammation and poor prognosis of atrial fibrillation based on 18F-FDG positron emission tomography/computed tomography

“…Sinigaglia et al found that RA DFG uptake may be associated with an increased prevalence of cardioembolic stroke ( 10 ). Previous study has shown that there is a significant decrease in RA FDG activity after RFCA compared to baseline scans, indicating that atrial FDG uptake can be reversed once AF is terminated ( 28 ). Our study assessed the association between RA FDG uptake and adverse prognosis, irrespective of whether the patients underwent RFCA.…”

Remote ischemic preconditioning enhances aerobic performance by accelerating regional oxygenation and improving cardiac function during acute hypobaric hypoxia exposure

“…To validate the results of the proteomic analysis, three key proteins-Tβ4, HSP70, and HSP90-which have been reported to be involved in the regulation of cardiac function (Bock-Marquette et al, 2004;Smart et al, 2011;Chakafana et al, 2021;Chen et al, 2021), exercise performance (Davison and Brown, 2013;Gonzalez-Franquesa et al, 2021;Samadian et al, 2021) and high-altitude acclimatization (Jain et al, 2013) were chosen for further study by using ELISA kits. In addition, the expression of Tβ4, HSP70, and HSP90 were detected in another independent validation cohort after 8 consecutive days of RIPC intervention without HH exposure.…”