Association of serum betatrophin with fibroblast growth factor-21 in women with polycystic ovary syndrome

Kahraman, Seda; Altınova, Alev Eroğlu; Yalcin, Mehmet Muhittin; Gülbahar, Özlem; Arslan, Burak; Aktürk, Müjde; Çakır, Nuri; Törüner, Füsun Baloş

doi:10.1007/s40618-018-0831-2

Cited by 13 publications

(4 citation statements)

References 39 publications

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“…Of the metabolic cytokines studied here, we only found that lipocalin-2 concentrations were increased in non-obese women with PCOS compared with female controls. The study of these circulating molecules on PCOS yielded largely discrepant results, not only with our present data, but also among earlier reports [56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71]. Such discrepancies might reflect the heterogeneity and complex nature of PCOS, but also differences among studies in the criteria used to diagnose the syndrome and in the characteristics of the population in terms of the association with obesity and other confounding factors which influence heavily metabolic variables.…”

Section: Discussioncontrasting

confidence: 64%

Metabolic Cytokines at Fasting and During Macronutrient Challenges: Influence of Obesity, Female Androgen Excess and Sex

et al. 2019

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Scope: Cytokines have pleiotropic functions within the organism and their levels may be influenced by obesity, visceral adiposity and sex hormones. Diet composition may also affect their systemic concentrations during fasting and in the postprandial period. Hence, we studied the influence of sex steroids and obesity on the circulating levels of a panel of metabolic cytokines in the fasting state and after single macronutrient challenges. Methods: On alternate days we submitted 17 women with polycystic ovary syndrome (PCOS) (9 non-obese, 8 obese), 17 non-hyperandrogenic control women (9 non-obese, 8 obese) and 19 control men (10 non-obese, 9 obese) to isocaloric oral glucose, lipid and protein loads. Serum levels of omentin-1, vaspin, lipocalin-2, adipsin, PAI-1, chemerin, FGF-21 and FGF-23 were determined by Luminex multiplex technology. Results: During fasting, obese patients presented higher levels of PAI-1, chemerin and adipsin but decreased FGF-23 and omentin-1 compared with non-obese subjects. Vaspin showed sexual dimorphism with lower levels in men than women with PCOS and female controls. Following macronutrient ingestion, most metabolic cytokines presented a similar physiological response consisting of a decrease in circulating concentrations, which was inversely associated with the fasting levels of these molecules. Protein intake caused the major postprandial decrease whereas glucose did not significantly reduce PAI-1, FGF-23 and vaspin, and even increased FGF-21. Regardless of the macronutrient administered, vaspin levels showed a larger reduction in non-obese individuals while the decrease in PAI-1 was particularly noticeable in the obese subgroup. The postprandial reductions of omentin-1 and FGF-23 after glucose and protein loads were influenced by obesity. No major differences were found between patients with PCOS and male and female controls. Conclusions: Obesity, but not PCOS or sex, markedly influences metabolic cytokine levels at fasting and after macronutrient ingestion. The observed postprandial decrease in their circulating concentrations might represent a physiological compensatory mechanism against food-induced inflammation and oxidative stress. This mechanism is altered by obesity and is differently modulated by macronutrients, suggesting a larger contribution of glucose to stressful postprandial responses.

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Section: Discussioncontrasting

confidence: 64%

Metabolic Cytokines at Fasting and During Macronutrient Challenges: Influence of Obesity, Female Androgen Excess and Sex

et al. 2019

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“…Many researchers have studied FGF21 in adult PCOS patients because of its observed action in metabolic disturbances and proinflammatory pathways, but none in adolescents. Half of the studies about FGF21 demonstrated no differences between the patients and the controls [62,[68][69][70], while others demonstrated prominent FGF21 concentrations in patients with PCOS [71][72][73][74]. This study did not demonstrate any differences in the concentrations of FGF21 between PCOS patients and healthy controls, but the FGF21 concentrations were significantly higher in patients with PCOS and NAFLD than those with PCOS without NAFLD.…”

Section: Discussioncontrasting

confidence: 50%

Hepatokine Profile in Adolescents with Polycystic Ovary Syndrome: A Case–Control Study

Giannouli,

Stefanaki,

Kouskoutis

et al. 2023

JCM

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The current guidelines suggest routine screening for non-alcoholic fatty liver disease (NAFLD) in patients with polycystic ovary syndrome (PCOS). Hepatokines seem to be promising surrogate endpoints for the diagnosis and severity of NAFLD. PCOS has its onset in adolescence and its metabolic sequalae begin during the same period. There are scarce data on the hepatokine profile of adolescent PCOS patients. This case–control study examined the serum profile of the hepatokines sex hormone-binding globulin (SHBG), selenoprotein P, fibroblast growth factor 21 (FGF21), and fetuin A in a sample of adolescent PCOS patients, and their association to metabolic and hormonal parameters. The selenoprotein P and SHBG serum concentrations were significantly decreased in PCOS patients vs. the controls (median (IQR), 2.47 (0.40) vs. 2.66 (0.36) μg/mL, p = 0.025; mean ± SD, 41.71 ± 19.41 vs. 54.94 ± 22.12 nmol/L, p = 0.011, respectively), whereas selenoprotein P was significantly and positively associated with testosterone (r = 0.325, p = 0.007) and the free androgen index (r = 0.361, p = 0.002). The SHBG demonstrated multiple significant negative correlations with adverse metabolic parameters. Among the PCOS patients, the FGF21 concentrations were significantly higher in those with NAFLD, whereas a 1 pg/mL increase in the FGF21 concentration increased the odds of NAFLD diagnosis by liver ultrasound by 1%, suggesting FGF21 as a potential biomarker for hepatic disease in females with PCOS in adolescence. Fetuin A was the least differentiated hepatokine between the PCOS patients and controls with the least associations with metabolic and hormonal parameters.

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“…PCOS is the most common endocrine disorder in the fertile female age group and hyperandrogenism,oligoanovulation, and polycystic ovarian morphology are the main features of disease (1,2). These features are related to future metabolic risks for the patient such as obesity, insulin resistance (IR), glucose intolerance, diabetes and metabolic syndrome (3-5).…”

Section: Introductionmentioning

confidence: 99%

Zayif Ve Obez Pcos’ Da İnsüli̇n Rezi̇stansi Ve Kan Betatrofi̇n Düzeyleri̇ Arasindaki̇ İli̇şki̇

Bedir Fındık,

Taşçı,

Akkaya

et al. 2024

Jinekoloji-Obstetrik Ve Neonatoloji Tıp Dergisi

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Amaç: Polikistik over sendromlu (PKOS) kadınların yaklaşık %70'inde insülin direnci ve buna bağlı metabolik bozukluklar vardır, ancak insülin direncine yol açan altta yatan mekanizma bilinmemektedir. Betatrofin, karaciğerde ve yağ dokusunda eksprese edilen ve insülin direnci ve β-hücre proliferasyonu ile ilişkili olduğu bulunan bir proteindir. Bu çalışmanın amacı, PKOS olgularında dolaşımdaki betatrofin düzeyini değerlendirmek ve obezite ve insülin direnci ile ilişkisini araştırmaktır. Yöntemler: Bu prospektif kesitsel çalışmada, ELİSA test kitleri kullanılarak normo-ağırlıklı 35 tane PCOS vakasında ve 38 tane fazla kilolu/obez PCOS vakasında (BMI≥25) dolaşan betatrofin seviyeleri ölçüldü. Betatrofin seviyeleri, antropometrik ölçümler, açlık kan şekeri, glikoz yüklemesinden 2 saat sonra kan şekeri ve insülin direncinin homeostaz modeli değerlendirmesi (HOMA-IR) değerleri karşılaştırıldı. Bulgular: Normal ağırlıklı PKOS grubunun dolaşımdaki betatrofin düzeyleri aşırı kilolu/obez PKOS grubuna göre anlamlı derecede yüksek bulundu (p=0,023). Betatrofin ve HOMA-IR seviyeleri arasında anlamlı bir ilişki yoktu. Sonuç: Betatrofin, aşırı kilolu/obez grupta normo-ağırlıklı PKOS grubuna göre anlamlı derecede düşük bulundu. Betatrofinin PKOS ve insülin direncindeki rolü yeterince aydınlatılamadığından PKOS hastalarında insülin direncinin iyi bir öngörücüsü olmadığı söylenebilir.

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Association of serum betatrophin with fibroblast growth factor-21 in women with polycystic ovary syndrome

Abstract: Our results indicate that betatrophin levels are increased and associated with LH and FGF-21 levels, but not with insulin resistance, in women with PCOS.

Cited by 13 publications

References 39 publications

Metabolic Cytokines at Fasting and During Macronutrient Challenges: Influence of Obesity, Female Androgen Excess and Sex

Metabolic Cytokines at Fasting and During Macronutrient Challenges: Influence of Obesity, Female Androgen Excess and Sex

Hepatokine Profile in Adolescents with Polycystic Ovary Syndrome: A Case–Control Study

Zayif Ve Obez Pcos’ Da İnsüli̇n Rezi̇stansi Ve Kan Betatrofi̇n Düzeyleri̇ Arasindaki̇ İli̇şki̇

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