Association of Serum Betatrophin with Fibroblast Growth Factor-21 in Women with Polycystic Ovary Syndrome

Kahraman, Seda; Altınova, Alev Eroğlu; Yalcin, Mehmet Muhittin; Gülbahar, Özlem; Arslan, Burak; Aktürk, Müjde; Çakır, Nuri; Törüner, Füsun Baloş

doi:10.25179/tjem.20182202-p171

Cited by 3 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In PCOS patients, circulating ZAG levels were reported to be consistently reduced [10,27,28]. However, the relationship between circulating betatrophin levels and PCOS is controversial and the studies in the literature are inconsistent [20][21][22][23][24][25][26][27][28][29][30][31][32][33][34]. Growing evidence indicates that these cytokines have some roles in the pathogenesis of T2DM and PCOS, and are also involved in IR development.…”

Section: Discussionmentioning

confidence: 99%

Several Circulating Biomarkers for PCOS Diagnosis

Luo

Zhang

et al. 2019

Exp Clin Endocrinol Diabetes

View full text Add to dashboard Cite

Aims Irisin, Betatrophin and Zinc-α2-glycoprotein (ZAG) have been shown to be associated with insulin resistance (IR) and polycystic ovary syndrome (PCOS), respectively. The purpose of this study is to explore the potential accuracy of this combination of three cytokines in screening PCOS. Methods 186 individuals were recruited for this study. Circulating Irisin, Betatrophin and ZAG concentrations were measured by enzyme-linked immunosorbent assay. The association between these serum biomarkers and PCOS was assessed by logistic regression analysis. Receiver operating curve (ROC) analysis was performed to evaluate the diagnostic value of these biomarkers for PCOS women. Results In women with PCOS, serum Irisin and Betatrophin levels were markedly elevated compared to those in healthy controls (p<0.01), while ZAG levels were lower (p<0.01). PCOS women with IR (M-value<6.28) had lower circulating ZAG concentrations, and higher circulating Irisin and Betatrophin levels relative to PCOS women without IR (M-value ≥ 6.28). ROC curve analyses showed that the AUC for Irisin, ZAG and Betatrophin for predicting PCOS were 0.77, 0.83 and 0.85, respectively. In a joint ROC curves analysis of these serum markers and other parameters, the results showed that the AUC was 0.93, and the sensitivity and specificity were 82.1 % and 92.3 %, respectively. Conclusions When compared to using single cytokine, the analysis of Irisin, ZAG and Betatrophin elevates the accuracy in diagnosing PCOS.

show abstract

Section: Discussionmentioning

confidence: 99%

Several Circulating Biomarkers for PCOS Diagnosis

Luo

Zhang

et al. 2019

Exp Clin Endocrinol Diabetes

View full text Add to dashboard Cite

show abstract

“…It's been reported that DCI-phosphoglycan and MI-phosphoglycan control key enzymes were involved in glucose and lipid metabolism [32,33]. β-trophin is a highly effective and specific pro-angiogenic factor, which acts through tyrosine kinase receptors to promote increased vascular permeability, extracellular matrix degeneration, and vascular endothelial cell migration [34,35]. In addition, elevated levels of androgen in patients with PCOS also lead to increased levels of β-trophin secreted by ovarian cells, which in turn exacerbates vascular proliferation in these patients [36].…”

Section: Discussionmentioning

confidence: 99%

The role of serum β-trophin and endostatin in patients with polycystic ovary syndrome: Are they correlated?

et al. 2021

View full text Add to dashboard Cite

Background It’s necessary to investigate the serum β-trophin and endostatin (ES) level and its influencing factors in patients with newly diagnosed polycystic ovary syndrome (PCOS). Methods Newly diagnosed PCOS patients treated in our hospital were selected, and healthy women who took physical examination during the same period as healthy controls. We detected and compared the related serum indicators between two groups, Pearson correlation were conducted to identify the factors associated with β-trophin and ES, and the influencing factors of β-trophin and ES were analyzed by logistic regression. Results A total of 62 PCOS patients and 65 healthy controls were included. The BMI, WHI, LH, FSH, TT, FAI, FBG, FINS, HOMA-IR, TC, TG, LDL, ES in PCOS patients were significantly higher than that of healthy controls, while the SHBG and HDL in PCOS patients were significantly lower than that of healthy controls (all p < 0.05). β-trophin was closely associated with BMI (r = 0.427), WHR (r = 0.504), FBG (r = 0.385), TG (r = 0.405) and LDL (r = 0.302, all p < 0.05), and ES was closely associated with BMI (r = 0.358), WHR (r = 0.421), FBG (r = 0.343), TC (r = 0.319), TG (r = 0.404, all p < 0.05). TG, BMI, WHR and FBG were the main factors affecting the serum β-trophin levels (all p < 0.05). FBG, TC and BMI were the main factors affecting the serum ES levels (all p < 0.05). The TG, β-trophin, ES level in PCOS patients with insulin resistance (IR) were significantly higher than that of those without IR (all p < 0.05). Conclusion Increased β-trophin is closely associated with increased ES in patients with PCOS, which may be the useful indicators for the management of PCOS.

show abstract

“…A strongly positive correlation was found between circulating betatrophin levels and LH, free-testosterone, HOMA-IR, BMI, insulin, FBG, and lipid profile (triglycerides, LDL-C, and total cholesterol) in both groups Calan et al [16]. Kahraman et al [17] suggested that betatrophin may participate in hormonal disturbances, especially LH alterations, in women with PCOS. The mechanism underlying the association between betatrophin and LH may be related to the signaling pathways between pituitary and liver, which may result in the stimulation of betatrophin by LH as a pituitary hormone.…”

Section: Fig 4 Correlation Between Betatrophin and Wisp1 Non-obese mentioning

confidence: 93%

A Potential Pathological Role of Wingless Type1 Inducible Signaling Pathway Protein-1 and Betatrophin in Obese Women with Polyststic Ovary Syndrome

Hassan

Mohammed

Abdelatif

et al. 2020

AJBGMB

View full text Add to dashboard Cite

Background: Polycystic Ovary Syndrome is a common female endocrinopathy. It is associated with adipokines dysfunctional secretion pattern and insulin resistance, which is considered as the main reason for its clinical feature. Wingless type1 inducible signaling pathway protein-1 is a novel adipokine that displays insulin resistance and adipose tissue inflammation where it strongly related to adipocyte accumulation and regeneration. Betatrophin has a potential role in pancreatic beta-cell proliferation and obesity and several studies showed inconsistent betatrophin levels in patients with diabetes and obesity but, its relation to polycystic ovary syndrome is unclear. Aim: Investigation of the role of serum wingless type1 inducible signaling pathway protein-1 and betatrophin in normal weight and obese patients with polycystic ovary syndrome. Studying their association with other markers, then determine whether obesity and insulin resistance is associated with them. Methods: Wingless type1 inducible signaling pathway protein-1 and betatrophin serum levels were measured in 44 patients with polycystic ovary syndrome (22 obese and 22 non-obese) and 44 matched control (22 obese and 22 non-obese) females using specific ELISA kits. Results: Betatrophin and wingless type1 inducible signaling pathway protein-1 levels were elevated in the polycystic ovary syndrome group (49.4 pg/ml, 187.6 pg/ml) than in the control group (32.08 pg/ml, 108.4 pg/ml) respectively. Moreover, their levels were higher in the obese subgroup than in normal weight subgroup. There were positive correlations between wingless type1 inducible signaling pathway protein-1 and betatrophin in non-obese (r=0.89, p=0.0001***) and in obese (r=0.78, p=0.0001***) polycystic ovary syndrome groups. Conclusion: Betatrophin and wingless type1 inducible signaling pathway protein-1 are associated with adiposity and insulin resistance in polycystic ovary syndrome. Hence wingless type1 inducible signaling pathway protein-1 and betatrophin may play a role in the incidence of polycystic ovary syndrome. They may be valuable in diagnosis and prediction of polycystic ovary syndrome patients.

show abstract

Association of Serum Betatrophin with Fibroblast Growth Factor-21 in Women with Polycystic Ovary Syndrome

Cited by 3 publications

References 0 publications

Several Circulating Biomarkers for PCOS Diagnosis

Several Circulating Biomarkers for PCOS Diagnosis

The role of serum β-trophin and endostatin in patients with polycystic ovary syndrome: Are they correlated?

A Potential Pathological Role of Wingless Type1 Inducible Signaling Pathway Protein-1 and Betatrophin in Obese Women with Polyststic Ovary Syndrome

Contact Info

Product

Resources

About