Association of serum asymmetric dimethylarginine, homocysteine, and l-arginine concentrations during early pregnancy with hypertensive disorders of pregnancy

Maruta, Ei; Wang, Jingwen; Kotani, Tomomi; Tsuda, Hiroyuki; Nakano, Tomoko; Imai, Kenji; Sato, Seiji; Niwa, Yoshimitsu; Mitsui, Takashi; Yoshida, Shigeru; Yamashita, Mamoru; Nawa, Akihiro; Koji, Takehiko; Kajiyama, Hiroaki; Kikkawa, Fumitaka

doi:10.1016/j.cca.2017.10.007

Cited by 9 publications

(5 citation statements)

References 30 publications

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“…As in our previous report, ADMA-treated embryonic kidneys (metanephroi) results in dose-dependent decreases of nephron number [32]. Increased plasma ADMA levels are associated with adverse pregnancy and fetal outcomes such as preeclampsia [41], gestational diabetes [42], hypertension [43], IUGR [44], and prematurity [45].…”

Section: Oxidative Stress In Fetal Programmingsupporting

confidence: 53%

Developmental Origins of Kidney Disease: Why Oxidative Stress Matters?

Hsu

Tain

2020

Antioxidants

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The “developmental origins of health and disease” theory indicates that many adult-onset diseases can originate in the earliest stages of life. The developing kidney has emerged as being particularly vulnerable to adverse in utero conditions leading to morphological and functional changes, namely renal programming. Emerging evidence indicates oxidative stress, an imbalance between reactive oxygen/nitrogen species (ROS/RNS) and antioxidant systems, plays a pathogenetic role in the developmental programming of kidney disease. Conversely, perinatal use of antioxidants has been implemented to reverse programming processes and prevent adult-onset diseases. We have termed this reprogramming. The focus of this review is twofold: (1) To summarize the current knowledge on oxidative stress implicated in renal programming and kidney disease of developmental origins; and (2) to provide an overview of reprogramming effects of perinatal antioxidant therapy on renal programming and how this may prevent adult-onset kidney disease. Although early-life oxidative stress is implicated in mediating renal programming and adverse offspring renal outcomes, and animal models provide promising results to allow perinatal antioxidants applied as potential reprogramming interventions, it is still awaiting clinical translation. This presents exciting new challenges and areas for future research.

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Section: Oxidative Stress In Fetal Programmingsupporting

confidence: 53%

Developmental Origins of Kidney Disease: Why Oxidative Stress Matters?

Hsu

Tain

2020

Antioxidants

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“…It is discovered that the immune system plays an important role in the occurrence and development of PIH. Immune cells play an important role in the pathogenesis of PIH by synthesizing and secreting cytokines [20,21]. In the present study, we demonstrated that the ratio and activity of NKT cells in peripheral blood and placental tissues from PIH patients was elevated.…”

Section: Resultssupporting

confidence: 59%

Natural killer T cells from peripheral blood of patients with pregnancy-induced hypertension inhibit the proliferation and migration of vascular endothelial cells by secreting interleukin-17

Zhao¹,

Liu²,

Qi³

2019

Biotechnology & Biotechnological Equipment

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“…Homocysteine serves as the principal functional biomarker of OCM, and undergoes catabolism via remethylation and transsulfuration pathways, where folate acts as a methyl donor and vitamins B 6 and B 12 function as enzyme cofactors. Maternal Hcy concentration decreased from early to mid-gestation and increased from mid-to-late gestation in a normal pregnancy ( 36 ). Clinical studies have highlighted the potential impact of elevated maternal homocysteine during pregnancy on fetal cognitive decline ( 20 ) and Down’s syndrome ( 22 ).…”

Section: Discussionmentioning

confidence: 99%

“…Clinical studies have highlighted the potential impact of elevated maternal homocysteine during pregnancy on fetal cognitive decline ( 20 ) and Down’s syndrome ( 22 ). Insights from the Ottawa and Kingston birth cohort suggest an independent effect of early to mid-pregnancy elevated maternal Hcy on placenta-mediated pregnancy complications, even on children’s cardiovascular-metabolic diseases after delivery ( 13 , 36 , 37 ). In this study, 1.8% of mid-to-late pregnant women exhibited HHcy, with adequate blood folate and vitamin B 6 identified as protective factors against HHcy.…”

Section: Discussionmentioning

confidence: 99%

Assessment of blood one-carbon metabolism indexes during mid-to-late pregnancy in 397 Chinese pregnant women

Zhang,

Wu,

et al. 2024

Front. Nutr.

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ObjectivesOne-carbon metabolism (OCM) significantly influences fetal growth and neurodevelopment through transferring methyl group to biomolecules, during which folate, methionine, choline and betaine function as methyl donor nutrients, while vitamin B2, B6, B12 function as enzyme cofactors, and homocysteine (Hcy) and S-adenosyl methionine (SAM) are functional metabolites. This study aimed to assess blood OCM index levels and explore their relationships among Chinese pregnant women.MethodsData were obtained from the baseline of the Mother–Child Nutrition and Health Cohort Study. Pregnant women, voluntarily recruited from September 2020 to June 2022 during antenatal examinations in five Chinese cities at 24–32 gestational weeks, provided fasting venous blood samples. Measurements included RBC and serum folate, serum vitamin B2, B6, B12, choline, betaine, methionine, total Hcy (tHcy), and plasma SAM. Sociodemographic characteristics and pregnancy-related conditions were collected via a self-designed questionnaire.ResultsOf 397 participants, 82.6% were in mid-pregnancy (24–27 gestational weeks) and 17.4% were in late-pregnancy (28–32 gestational weeks). Serum folate, vitamin B6, and B12 deficiencies were 2.5, 1.3, and 8.3%, respectively. Elevated tHcy (≥10 μmol/L) was observed in 1.8% of pregnant women. Elderly pregnant women (aged 35 and above) exhibited significantly lower serum methionine levels (p < 0.05), while multiparous women had lower RBC folate levels (p < 0.05), and lower serum methionine and vitamin B12 levels (p < 0.10, not statistically significant). Partial correlation analysis revealed positive associations between RBC folate and cofactor vitamin B12 (r = 0.244, p < 0.05) in the folate cycle, as well as significant correlations between two methyl donor paths [serum folate was significantly related to serum choline (r = 0.172) and betaine (r = 0.193)]. As functional biomarkers of OCM, serum tHcy exhibited negative associations with RBC folate (β = −0.330, p < 0.05) and vitamin B6 (β = −0.317, p < 0.05), and plasma SAM displayed a positive association with serum betaine (β = 0.610, p < 0.05), while negatively associated with serum vitamin B6 (β = −0.181, p < 0.05).ConclusionThe blood OCM exhibited imbalances during mid-to-late pregnancy, characterized by lower levels of folate, vitamin B6, and B12, alongside elevated tHcy levels. Adequate folate and vitamin B6 emerged as significant predictors of lower tHcy levels. Additionally, serum betaine showed a positive correlation with plasma SAM. This suggests the importance of not only ensuring sufficient folate but also optimizing other OCM-related nutrients throughout pregnancy.

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Association of serum asymmetric dimethylarginine, homocysteine, and l-arginine concentrations during early pregnancy with hypertensive disorders of pregnancy

Cited by 9 publications

References 30 publications

Developmental Origins of Kidney Disease: Why Oxidative Stress Matters?

Developmental Origins of Kidney Disease: Why Oxidative Stress Matters?

Natural killer T cells from peripheral blood of patients with pregnancy-induced hypertension inhibit the proliferation and migration of vascular endothelial cells by secreting interleukin-17

Assessment of blood one-carbon metabolism indexes during mid-to-late pregnancy in 397 Chinese pregnant women

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