Association of serum and follicular fluid leptin and in vitro Fertilization/ ICSI outcome: A systematic review and meta-analysis

Jafarpour, Sima; Khosravi, Sharifeh; Janghorbani, Mohsen; Mansourian, Marjan; Karimi, Raheleh; Ghiasi, Moosa Rahimi; Miraghajani, Maryam; Symonds, Michael; Farajzadeghan, Ziba; Salehi, Roya

doi:10.1016/j.jogoh.2020.101924

Cited by 3 publications

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“…Leptin also affects the hypothalamic–pituitary–gonadal axis and the secretion of gonadotropins. Thus, leptin plays a central role in reproduction and may be one component explaining the negative effect of obesity on IVF outcome 39 . Interestingly, in women undergoing IVF, lower levels of leptin in follicular fluid were associated with a higher probability of live birth, suggesting a direct effect of leptin on ovarian function 40 .…”

Section: Discussionmentioning

confidence: 99%

Inflammatory and metabolic markers in relation to outcome of in vitro fertilization in a cohort of predominantly overweight and obese women

Svensson

Einarsson

Olausson

et al. 2022

Sci Rep

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For overweight and obese women undergoing in vitro fertilization (IVF) the pregnancy and live birth rates are compromised while the underlying mechanisms and predictors are unclear. The aim was to explore the association between adipose tissue-related inflammatory and metabolic markers and the pregnancy and live birth outcome of IVF in a cohort of predominantly overweight and obese women. Serum samples, fulfilling standardizing criteria, were identified from 195 women having participated in either the control (n = 131) or intervention (n = 64) group of a randomized controlled trial (RCT), seeking to evaluate the effect of a weight reduction intervention on IVF outcome in obese women. Serum high-sensitivity C-reactive protein (hsCRP) and the adipokines leptin and adipocyte fatty acid-binding protein (AFABP) were analyzed for the whole cohort (n = 195) in samples collected shortly before IVF [at randomization (control group), after intervention (intervention group)]. Information on age, anthropometry [BMI, waist circumference, waist-to-height ratio (WHtR)], pregnancy and live birth rates after IVF, as well as the spontaneous pregnancy rate, was extracted or calculated from collected data. The women of the original intervention group were also characterized at randomization regarding all variables. Eight women [n = 3 original control group (2.3%), n = 5 original intervention group (7.8%)] conceived spontaneously before starting IVF. BMI category proportions in the cohort undergoing IVF (n = 187) were 1.6/20.1/78.3% (normal weight/overweight/obese). The pregnancy and live birth rates after IVF for the cohort were 35.8% (n = 67) and 24.6% (n = 46), respectively. Multivariable logistic regression revealed that none of the variables (age, hsCRP, leptin, AFABP, BMI, waist circumference, WHtR) were predictive factors of pregnancy or live birth after IVF. Women of the original intervention group displayed reductions in hsCRP, leptin, and anthropometric variables after intervention while AFABP was unchanged. In this cohort of predominantly overweight and obese women undergoing IVF, neither low-grade inflammation, in terms of hsCRP, other circulating inflammatory and metabolic markers released from adipose tissue (leptin, AFABP), nor anthropometric measures of adiposity or adipose tissue distribution (BMI, waist, WHtR) were identified as predictive factors of pregnancy or live birth rate.Trial registration: ClinicalTrials.gov number, NCT01566929. Trial registration date 30-03-2012, retrospectively registered.

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Section: Discussionmentioning

confidence: 99%

Inflammatory and metabolic markers in relation to outcome of in vitro fertilization in a cohort of predominantly overweight and obese women

Svensson

Einarsson

Olausson

et al. 2022

Sci Rep

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show abstract

“…Second, follicular uid sampling like other studies presents a limitation (Jafarpour et al, 2021). We used pooled follicular uid which is still better than sampling just the rst follicle.…”

Section: Limitationsmentioning

confidence: 99%

“…Leptin is a neuroendocrinal that exists in excess in obese women. Integrating follicular uid leptin in our study is rationalized by; First: leptin is a re ection of the oocyte microenvironment; Second: leptin receptors and m-RNA are expressed in granulosa cells(Lö er et al, 2001), oocytes(Cio et al, 1997;Antczak and Van Blerkom, 1997) and pre-implantation embryos(Antczak and Van Blerkom, 1997); Third: leptin is depicted to regulate ovarian steroidogenesis, follicular growth and apoptosis, and oocyte maturation(Craig et al, 2004;Sirotkin et al, 2008); Fourth: controversial reports exist for the impact of FF leptin on cycle outcomes in the studied infertile cohort(Mantzoros et al, 2000;Anifandis et al, 2005;Jafarpour et al, 2021).Our results concur with the results of a recent metanalysis evaluating(Jafarpour et al, 2021) 11 observational studies (266 pregnant and 552 non-pregnant cases). This metanalysis indicated that pregnancy was unrelated to leptin levels in the follicular uid.…”

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confidence: 99%

Revisiting the predictability of follicular fluid leptin and related adiposity measures for live birth in women scheduled for ICSI cycles, a prospective cohort study.

A;,

Makhlouf,

Abdel-Aleem

et al. 2023

Preprint

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Background Our research question is; could follicular fluid (FF) leptin solely or contemporaneously with other clinical, biochemical and sonographic adiposity measures predict the probability of having a live birth during ICSI cycles? .This is a prospective cohort study that enrolled infertile women without polycystic ovary syndrome scheduled for ICSI. At baseline, women had assessment of obesity using different metrics: clinical, serum biochemical, and sonographic. Clinical measures encompassed waist circumference and body mass index. Biochemical evaluation comprised assessment of homeostasis-model for insulin resistance, visceral adiposity index and lipid accumulation product. Preperitoneal and subcutaneous abdominal fat were measured using ultrasound and body fat index was calculated. On day of oocyte retrieval, pooled FF was sampled to assess FF leptin. Our primary outcome was live birth after one fresh embryo transfer cycle. Results Out of Ninty-one women analyzed in this study, 28 have a live birth (30.8%). No difference in FF leptin concentration was found between women with and without live birth (Mean ± SD; 20336 ± 8006 vs 18493 ± 6655 pg/ml; P = 0.2). None of the assessed adiposity markers was a predictor for live birth. Substantially, follicular fluid leptin was positively correlated with insulin resistance in women with and without live birth (r = 0.21, P = 0.04). In logistic regression analysis, the outcome of the prior cycle, ability to have cryopreserved embryos, and the oocyte maturation index were the predictors for live birth in our study. Conclusions The present work could not find evidence that follicular fluid leptin, preperitoneal fat and other evaluated adiposity measures could impact live birth after ICSI cycles.

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Revisiting the predictability of follicular fluid leptin and related adiposity measures for live birth in women scheduled for ICSI cycles: a prospective cohort study

Abdelmagied,

Makhlouf,

Abdel-Aleem

et al. 2024

Middle East Fertil Soc J

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Background Our research question is could follicular fluid (FF) leptin solely or contemporaneously with other clinical, biochemical, and sonographic adiposity measures predict the probability of having a live birth during ICSI cycles? This is a prospective cohort study that enrolled infertile women without polycystic ovary syndrome scheduled for ICSI. At baseline, women had an assessment of obesity using different metrics: clinical, serum biochemical, and sonographic. Clinical measures encompassed waist circumference and body mass index. Biochemical evaluation comprised an assessment of the homeostasis model for insulin resistance, visceral adiposity index, and lipid accumulation product. Preperitoneal and subcutaneous abdominal fat were measured using ultrasound and body fat index was calculated. On the day of oocyte retrieval, pooled FF was sampled to assess FF leptin. Our primary outcome was live birth after one fresh embryo transfer cycle. Results Out of 91 women analyzed in this study, 28 have a live birth (30.8%). No difference in FF leptin concentration was found between women with and without live birth (mean ± SD; 20336 ± 8006 vs 18493 ± 6655 pg/ml; P = 0.2). None of the assessed adiposity markers was a predictor for live birth. Substantially, follicular fluid leptin was positively correlated with insulin resistance in women with and without live birth (r = 0.21, P = 0.04). In logistic regression analysis, the outcome of the prior cycle, the ability to have cryopreserved embryos, and the oocyte maturation index were the predictors for live birth in our study. Conclusions The present work could not find evidence that follicular fluid leptin, preperitoneal fat, and other evaluated adiposity measures could impact live births after ICSI cycles.

show abstract

Association of serum and follicular fluid leptin and in vitro Fertilization/ ICSI outcome: A systematic review and meta-analysis

Cited by 3 publications

References 80 publications

Inflammatory and metabolic markers in relation to outcome of in vitro fertilization in a cohort of predominantly overweight and obese women

Inflammatory and metabolic markers in relation to outcome of in vitro fertilization in a cohort of predominantly overweight and obese women

Revisiting the predictability of follicular fluid leptin and related adiposity measures for live birth in women scheduled for ICSI cycles, a prospective cohort study.

Revisiting the predictability of follicular fluid leptin and related adiposity measures for live birth in women scheduled for ICSI cycles: a prospective cohort study

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