Association of Serum Albumin Level and Mortality in Premature Infants

Törer, Birgin; Hanta, Deniz; Yapakçı, Ece; Gökmen, Zeynel; Parlakgümüş, Alper; Gülcan, Hande; Tarcan, Aylin

doi:10.1002/jcla.21949

Cited by 25 publications

(21 citation statements)

References 22 publications

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“…In the light of our results, the levels of serum albumin in infants with AB are associated with the age, the weight for age percentile, and the inflammatory response. Accordingly, the positive correlation observed between the age and the serum albumin level has been previously recognized in neonates and small infants 24 , and malnutrition and inflammation are considered to play a major role in occurrence of hypoalbuminemia 9 . Although it has traditionally been linked to malnutrition and we observed that the weight for age percentile was independently associated to serum albumin levels, hypoalbuminemia is not considered a specific nutritional marker 9 .…”

Section: Discussionmentioning

confidence: 83%

Association of serum albumin levels with inflammation and clinical outcomes in children with acute bronchiolitis.

Rodríguez-González¹,

Rodríguez-Campoy²,

Estalella-Mendoza³

et al. 2020

Preprint

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Objective: To evaluate if hypoalbuminemia on admission predict disease severity in children with acute bronchiolitis (AB). Working hypothesis: Hypoalbuminemia is associated with worse outcome in infants with AB. Study design: Single-centre prospective cohort study. Patient-subject selection : Infants aged <12 month-old with AB. Methodology: Serum albumin levels were determined within the first 24 hours upon inclusion. The primary outcome was the need of pediatric intensive care unit (PICU) admission. Results: We enrolled 90 cases of AB. Serum albumin was independently associated with C-Reactive protein levels (CRP) (r s =-0,28; p=0.002). Fourteen (15.5%) cases required PICU admission. They presented lower serum albumin levels (3.7 (0.11) vs 4 (0.5) g/dl; p=0.034) regarding those patients without severe illness. In the multivariate logistic regression analysis, hypoalbuminemia was independently associated with a higher risk of severe illness (adjusted Odds Ratio 4.1 (1.2-85); p=0.032). The area under the ROC curve for serum albumin to predict adverse outcome was 0.70 (95% Confidence interval of 0.59-0.79). A cutoff point of 3.5 g/dl presented a sensitivity of 0.71, specificity of 0.68, positive predictive value of 0.29, and negative predictive value of 0.92. Conclusion:Low serum albumin levels at admission are significantly associated with higher PICU admission rates in infants with AB. The inflammatory response could play a key role in the occurrence of hypoalbuminemia in AB.

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Section: Discussionmentioning

confidence: 83%

Association of serum albumin levels with inflammation and clinical outcomes in children with acute bronchiolitis.

Rodríguez-González¹,

Rodríguez-Campoy²,

Estalella-Mendoza³

et al. 2020

Preprint

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“…Torer et al 8) investigated the association between serum albumin levels and mortality in premature infants. The prevalence of RDS, sepsis, and mortality was significantly higher in infants with serum albumin levels less than the 25th percentile.…”

Section: Discussionmentioning

confidence: 99%

“…In previous studies, low serum albumin within 1 day of birth was associated with longer hospital stay, need for mechanical ventilation, and higher mortality 8,9) .…”

Section: Introductionmentioning

confidence: 87%

“…Several markers, such as total protein, albumin, retinol-binding protein, insulin-like growth factor 1, prealbumin, and vitamin D, have been used as nutritional indicators [1][2][3][4] . Nutritional markers, including total protein, albumin, and vitamin D, are associated with neonatal mortality and other severe adverse outcomes [5][6][7][8][9][10][11] .…”

Section: Introductionmentioning

confidence: 99%

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Association between the Nutritional Status at Birth and Need for Respiratory Support on the First Day of Life

Jang¹,

Choi²,

Park³

et al. 2019

Neonatal Med

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Purpose: Nutritional markers, such as total protein, albumin, and vitamin D have been reportedly associated with neonatal outcomes. This study aimed to assess the correlation between nutritional markers at birth and the need for respiratory support on the first day of life. Methods: This retrospective study included 94 newborns admitted to the neonatal intensive care unit of Kyungpook National University Children's Hospital between March and December 2017. We measured levels of nutritional markers, including serum total protein, albumin, ferritin, 25-hydroxyvitamin D (25-OHD), and prealbumin, from cord blood or blood sample within 24 hours after birth. Respiratory support was defined as the use of nasal continuous positive airway pressure, humidified high-flow nasal cannula, or mechanical ventilation on the first day of life. Results: The mean gestational age and birth weight were 36.6±2.3 weeks and 2,714± 575 g, respectively. Serum total protein, albumin, prealbumin, and ferritin levels at birth were significantly correlated with gestational age and birth weight. Total protein, albumin, ferritin, and 25-OHD levels were not correlated with the time to recover birth weight after adjusting for gestational age. Moreover, prealbumin levels at birth were significantly lower in small-for-gestational-age infants than in appropriate-forgestational-age infants. The need for respiratory support on the first day of life decreased 0.058-and 0.001-fold for every 1 g/dL increase in serum total protein (95% confidence interval [CI], 0.004 to 0.833; P=0.036) and albumin (95% CI, 0.000 to 0.136; P=0.009) levels, respectively. Conclusion: Nutritional status at birth could be associated with the need for respiratory support on the first day of life, regardless of the Apgar score.

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“…In addition to the significant univariate predictors of neonatal mortality such as GA [ 8 ], BW [ 8 ], Apgar score [ 8 ], initial [ 9 , 10 ], and lowest serum albumin levels [ 9 ], a variety of risk adjustment scores such as clinical risk index for babies II (CRIB II) score—which assesses 5 combined variables of sex, GA, BW, body temperature, and base excess—have been found to be good predictors for mortality in preterm infants before 32 weeks of gestation [ 11 ]. The relationship of these variables with mortality is in need of further investigation in ELBWIs near the viability limit.…”

Section: Introductionmentioning

confidence: 99%

Predicting mortality in extremely low birth weight infants: Comparison between gestational age, birth weight, Apgar score, CRIB II score, initial and lowest serum albumin levels

et al. 2018

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We explored GA, BW, Apgar score, CRIB II score, and serum albumin levels as univariate predictors of mortality in extremely low birth weight infants. Medical records of 564 extremely low birth weight infants were reviewed retrospectively. The infants were grouped as survivors (group I), expired ≤ 7th postnatal day (group II), and expired > 7th postnatal day (group III). The predictive value for mortality of gestational age, birth weight, Apgar scores at 1 and 5 min, clinical risk index for babies II score, and first and lowest serum albumin levels was assessed by calculating the associated area under the curve (AUC) in receiver operating characteristic (ROC) curves. The overall survival and mortality rates of groups I, II, and III were 81.0% (457/564), 7.6% (43/564), and 11.4% (64/564), respectively. Birth weight, Apgar scores at 1 and 5 min, and first serum albumin levels were significantly higher, while the clinical risk index for babies II score was significantly lower in group I when compared to groups II and III. Gestational age and lowest serum albumin level in group I were significantly higher than group III, but not group II. However, gestational age, birth weight, and clinical risk index for babies II score showed gestational age dependent variations regardless of survival or mortality. Apgar score at 5 min (0.756) and lowest serum albumin level (0.771) demonstrated the highest AUC of the ROC curve in predicting mortality in group II and III, respectively. In conclusion, Apgar score at 5 min and lowest serum albumin level were the most effective predictors for mortality in extremely low birth weight infants during ≤ 7th and > 7th postnatal days, respectively.

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Association of Serum Albumin Level and Mortality in Premature Infants

Abstract: Low serum albumin level within the first day of life is an independent predictor of mortality in preterm infants.

Cited by 25 publications

References 22 publications

Association of serum albumin levels with inflammation and clinical outcomes in children with acute bronchiolitis.

Association of serum albumin levels with inflammation and clinical outcomes in children with acute bronchiolitis.

Association between the Nutritional Status at Birth and Need for Respiratory Support on the First Day of Life

Predicting mortality in extremely low birth weight infants: Comparison between gestational age, birth weight, Apgar score, CRIB II score, initial and lowest serum albumin levels

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