Association of Serum Albumin and Severity of Pulmonary Embolism

Omar, Hesham R.; Mirsaeidi, Mehdi; Rashad, Rania; Hassaballa, Hatem; Enten, Garrett; Helal, Engy; Mangar, Devanand; Camporesi, Enrico M.

doi:10.3390/medicina56010026

Cited by 27 publications

(25 citation statements)

References 35 publications

(31 reference statements)

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“… 11 Studies have found that low albumin level disrupts physiological functions of albumin, and it increases susceptibility to tromboembolic events, such as deep venous thrombosis and stroke. 12 - 14 Hypoalbuminemi was found to be an independent predictor of mortality in acute PE due to its’ prothrombotic effects, which supports our finding. 11 , 15 , 16 In our study, the value of AUC was statistically significant ( P < 0.001) for cut-off value of albumin <3.17 to predict 30 day mortality in intermediate-high risk acute PE.…”

Section: Discussionsupporting

confidence: 82%

In-hospital and short-term predictors of mortality in patients with intermediate-high risk pulmonary embolism

Gök¹,

Karadağ²,

Çınar³

et al. 2020

J Cardiovasc Thorac Res

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Introduction: The aim of this study was to evaluate the in-hospital and short-term predictive factors of mortality in intermediate-high risk acute pulmonary embolism (PE) patients with right ventricle (RV)dysfunction and myocardial injury. Methods: In this retrospective study, the medical records of 187 patients with a diagnosis of intermediate high risk acute PE were evaluated. A contrast-enhanced multi-detector pulmonary angiography was used to confirm diagnosis in all cases. All-cause mortality was determined by obtaining both in hospital and 30 days follow-up data of patients from medical records. Results: During the in-hospital stay (9.5±4.72 days), 7 patients died, resulting in an acute PE related in-hospital mortality of 3.2%. Admission heart rate (HR), (Odds ratio (OR), 1.028 95% Confidence interval (CI), 0.002-1.121; P = 0.048) and blood urea nitrogen (BUN) (OR, 1.028 95% CI, 0.002-1.016; P = 0.044) were found to be independent predictors for in-hospital mortality in a multi variate logistic regression analysis. In total, 32 patients (20.9%) died during 30 days follow-up.The presence of congestive heart failure (OR, 0.015, 95%CI, 0.001-0.211; P = 0.002) and dementia (OR, 0.029, 95%CI,0.002-0.516; P = 0.016) as well as low albumin level (OR, 0.049 95%CI, 0.006-0.383; P = 0.049) were associated with 30 days mortality. Conclusion: HR and BUN were independent predictors of in-hospital mortality and the presence of congestive heart failure, dementia, and low albumin levels were associated with higher 30 days mortality.

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Section: Discussionsupporting

confidence: 82%

In-hospital and short-term predictors of mortality in patients with intermediate-high risk pulmonary embolism

Gök¹,

Karadağ²,

Çınar³

et al. 2020

J Cardiovasc Thorac Res

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“…In a study from USA with 15300 people, authors reported increased rates of thromboembolism in cases with hypoalbuminemia (5) . Similarly, in a study on 552 patients with PTE hypoalbuminemia was found to be associated with severity of PTE (15) . There are several reasons for this association.…”

Section: Discussionmentioning

confidence: 80%

Effectiveness of lactate dehydrogenase to albumin ratio in diagnosis of pulmonary thromboembolism

Alanlı¹,

Küçükay²,

Yalcin³

2021

BMJ

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Background: The aim of the study is to inspect effectiveness of lactate dehydrogenase (LDH) to albumin ratio (LAR) in patients with pulmonary thromboembolism (PTE). Methods: In this single center and retrospective study, 307 patients who admitted to emergency unit, between January 2017 and March 2020, with chest pain and sudden developing dyspnea were enrolled. Computed tomography pulmonary angiogram (CTPA) were performed to confirm pulmonary embolism. Results: LAR, neutrophil, monocyte, d-dimer, LDH values were significantly higher and albumin values were significantly lower in patients with pulmonary embolism compared to patients without pulmonary embolism. Average age of 307 participants were 68.93; 140 patients were confirmed for PTE and 167 were normal. Linear regression analysis for LAR in diagnosis of PTE, revealed a correlation coefficient as r=0.320 (p<0.001). Positive and negative predictive values for LAR in diagnosisi of PTE were, 63.3% and 75.2%, respectively. In ROC analysis relation of LAR to PTE was found to be stronger than LDH and albumin tests alone. Conclusion: LAR, which is a very simple and available test, may be used as a novel parameter in diagnosis of PTE.

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“…There is no cellular infiltration in the pulmonary artery during the acute stage while leukocyte infiltration occurs within the subsequent three hours and two days, which decreases on the fourth day and returns to baseline levels on the eighth day (18). Inflammatory markers including WBC, HB, NE, LY, PLT, RDW, and MPV, which are inexpensive and standard biomarkers that are routinely measured in CBC, have recently become a major research area in the evaluation of PTE (21,22). In those studies, serum levels of these markers have been shown to decrease or increase in PTE.…”

Section: Resultsmentioning

confidence: 99%

Evaluation of factors affecting 90-day mortality in patients hospitalized due to pulmonary thromboembolism

Hoşgün

Aydemir²,

Ateş

2021

Journal of Health Sciences and Medicine

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Aim: Pulmonary thromboembolism (PTE) is a leading cause of death from vascular events. In the pathophysiology of PTE, inflammatory mediators have been shown to be upregulated and to interact with coagulation factors. In this study, we aimed to investigate the role of symptoms, clinical and radiological findings, and the blood parameters measured at presentation within the first 24 h after the onset of the symptoms in predicting 90-day mortality and intensive care unit (ICU) requirement in patients with PTE. Material and Method: The retrospective study included 264 PTE patients that were followed up at our Chest Diseases clinic and ICU between 2014 and 2019. Results: The 264 patients comprised 55.3% women and 44.7% men with a mean age of 62.80±15.95 years. Of these, 189 of them were hospitalized in the Chest Diseases clinic and the remaining 75 patients were followed up at ICU. Total mortality occurred in 8 (3%) out of 264 patients. Hospital and ICU mortality were determined at 1.9% , 1.1% respectively. The patients comprised 206 (78.0%) nonmassive PTE, 17 (6.5%) submassive PTE, and 41 (15.5%) massive PTE. Risk factors for 90-mortality included white blood cell count (WBC), red blood cell distribution width (RDW), mean platelet volume (MPV)/RDW ratio, right ventricular dilatation (RVD), recombinant tissue plasminogen activator (rtPA) therapy, ICU hospitalization, and increased APACHE II (Acute Physiology and Chronic Health Evaluation II) scores (p<0.05). Conclusion:The results indicated that TTE findings, baseline hemodynamic parameters and symptoms, rtPA therapy, and CBC parameters including WBC, NE, and RDW are significant risk factors for predicting both mortality and ICU requirement.

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Association of Serum Albumin and Severity of Pulmonary Embolism

Cited by 27 publications

References 35 publications

In-hospital and short-term predictors of mortality in patients with intermediate-high risk pulmonary embolism

In-hospital and short-term predictors of mortality in patients with intermediate-high risk pulmonary embolism

Effectiveness of lactate dehydrogenase to albumin ratio in diagnosis of pulmonary thromboembolism

Evaluation of factors affecting 90-day mortality in patients hospitalized due to pulmonary thromboembolism

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