Association of serum adiponectin with asthma and pulmonary function in the Japanese population

Yin

Journal of Investigative Medicine

et al. 2017

There is some evidence which shows that higher levels of serum leptin and lower levels of serum adiponectin are associated with the diagnosis of asthma. This meta-analysis evaluated the association of serum leptin and adiponectin levels with the diagnosis of asthma. We searched the MEDLINE, Cochrane, EMBASE and CINAHL Plus databases up to July 2015. Eligible studies were randomized controlled trials, prospective studies, retrospective studies, case-control studies and cohort studies. 13 studies with 3642 patients were included in the study. The meta-analysis found that in the overall study population, the diagnosis of asthma was associated with higher levels of leptin (pooled standardized difference in means=0.867, 95% CI 0.416 to 1.318, p<0.001) and lower levels of adiponectin (pooled standardized difference in means=-0.371, 95% CI -0.728 to -0.014, p=0.042) in patients with asthma compared with controls. Subgroup analysis found that higher leptin levels were associated with asthma both in adults (standardized difference in means=1.374, 95% CI 0.621 to 2.126, p<0.001) and children (standardized difference in means=0.302, 95% CI 0.010 to 0.594, p=0.042). However, borderline association of adiponectin with asthma was seen in adults (p=0.05), but not in children (p=0.509). Sensitivity analysis indicated that the findings for leptin were robust. Our findings are consistent with higher levels of serum leptin being associated with asthma regardless of age, and low adiponectin levels being associated with asthma in adults only.

Section: Resultsmentioning

confidence: 77%

Association of Asthma Diagnosis with Leptin and Adiponectin: A Systematic Review and Meta-Analysis

Yin

Journal of Investigative Medicine

et al. 2017

“…In a very recent study on Japanese adults, higher LMW adiponectin levels and lower middle molecular weight (MMW) adiponectin/total adiponectin ratio are significantly associated with current asthma [24]. Further mechanistic studies are required to clarify the roles of different isoforms of adiponectin in obesity-associated asthma.…”

Section: Discussionmentioning

confidence: 99%

Adipokines, asymmetrical dimethylarginine, and pulmonary function in adolescents with asthma and obesity

et al. 2016

“…The occurrence of obstruction of the airways in humans, may be associated with the levels of ADPN. Hayashikawa et al, reported that low levels of total serum ADPN in obesity may contribute to the predominance of smooth muscles in the airways 7 . However Wei et al, we observed that metabolic and cardiovascular diseases are associated with respiratory disorders 5 .…”

Section: Resultsmentioning

confidence: 99%

“…In addition to the alterations mentioned concerning the levels of cytokines, the accumulation of thoracic and abdominal fat may promote the reduction of total lung compliance, which leads to changes in the respiratory mechanics and influence on changes in forced expiratory volume in 1 second (FEV1) and peak expiratory flow (PEF) 7 .…”

Section: Introductionmentioning

confidence: 99%

Relação Entre O Nível De Adiponectina Com Medidas Antropométricas E Respiratórias De Pacientes Submetidos À Cirurgia De Revascularização Miocárdica.

Araujo¹,

Souza²,

Santana³

et al. 2019

Revista E-Ciência

RESUMOOs baixos níveis de adiponectina no plasma tem relação com o aumento da mortalidade em pacientes com doenças cardiovasculares, alterações da função pulmonar, sugerindo ação pró-inflamatória em decorrência da obesidade. Foram avaliados 65 pacientes, submetidos à cirurgia de revascularização do miocárdio. Analisados nível sérico da adiponectina, medidas antropométricas e respiratórias. Verificou-se que 55,8% dos pacientes do sexo masculino e 40% do feminino apresentaram sobrepeso e um IMC médio de 28,10 kg/m². Os maiores índices de sobrepeso foram verificados na faixa etária de 40 a 59 anos (62,5%) e de 60 anos ou mais (47,8%) O teste de comparação de proporção foi significativo para sexo (p=0,004), idade (p<0,001) e IMC (p=0,007). Quanto aos níveis de adiponectina verificou-se maior média no grupo masculino (média = 4,29), entre 40 a 59 anos (média = 4,70), com sobrepeso (média=4,70). Não houve relação entre o nível de adiponectina com as medidas antropométricas e respiratórias de pacientes submetidos à cirurgia de revascularização miocárdica.Palavras chaves: índice de massa corporal, adiponectina, antropometria, revascularização miocárdica. ABSTRACTLow plasma adiponectin levels are associated with increased mortality in patients with cardiovascular disease, changes of pulmonary function, suggesting that pro-inflammatory action as a result of obesity. We evaluated 65 patients submitted to myocardial revascularization surgery. Analyzed serum level of adiponectin, anthropometric and respiratory measures. It was verified that 55.8% of the male patients and 40% of the female patients were overweight and had an average BMI of 28.10 kg / m². The highest rates of overweight were found in the age group of 40-59 years old (62.5%) and 60 or older (47.8%). The proportion-comparison test was significant for gender (p = 0.004), age (p <0.001) and BMI (p = 0.007). Adiponectin levels were higher in the male group (average = 4.29), between 40 and 59 years old (average = 4.70), overweight (average = 4.70). There was no relationship between the level of adiponectin and the anthropometric and respiratory measurements of patients undergoing myocardial revascularization surgery.