Association of selenium levels with the prevention and control of Keshan disease: A cross-sectional study

Hou, Jie; Zhu, Lifang; Chen, Cuicui; Feng, Huiyun; Li, Dandan; Sun, Shuqiu; Xing, Zhifeng; Wan, Xiaoyan; Wang, Xiuhong; Li, Feng; Guo, Xianni; Xiong, Ping; Zhao, Shengcheng; Li, Shujuan; Sun, Di

doi:10.1016/j.jtemb.2021.126832

Cited by 22 publications

(14 citation statements)

References 31 publications

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“…Severe selenium deficiency is associated with Keshan disease, an endemic osteoarticular cardiomyopathy that is characterized by the selective necrosis of articular and growth plate chondrocytes (21). Bone has the second highest proportion of selenium (16%) in the body, only exceeded by skeletal muscles (27.5%) (22).…”

Section: Discussionmentioning

confidence: 99%

Association between dietary selenium intake and bone mineral density in the US general population

Xue¹,

Liu²

2022

Ann Transl Med

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Background: Osteoporosis, characterized by reduced bone mineral density (BMD) increases the risk of allcause mortality. Assessments of whether dietary selenium intake is related to bone health are scarce, with few relevant studies limited by a small sample size. The aim of the present study was to investigate the association between dietary selenium intake and BMD levels in the National Health and Nutrition Examination Survey (NHANES) database. Methods:We extracted and aggregated data from 4 cycles of the NHANES [2005][2006][2007][2008][2009][2010][2013][2014].Dietary selenium intake was obtained from 24-hour dietary recall interviews. BMD measurement, including the femur, femur neck, trochanter and intertrochanter of the femur, and lumbar spine, was performed using dual-energy X-ray absorptiometry. The multivariable linear regression model for the association between dietary selenium intake and BMD and the generalized additive model (GAM) for the dose-response relationship were used.Results: A total of 21,939 participants were included. The mean age was 40.68±22.42 years, and 51.28% were male. In the multivariable adjustment model, participants with the highest quintiles of dietary selenium intake (Q5) were associated with increased BMD levels in the total femur (β=0.

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Section: Discussionmentioning

confidence: 99%

Association between dietary selenium intake and bone mineral density in the US general population

Xue¹,

Liu²

2022

Ann Transl Med

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“…Since most heart failure patients have less than 100 μg/L of Se, a minimum of 90 μg/L is required to achieve plateau levels of selenoproteins, suggesting a potential benefit of Se supplementation in heart failure (Al‐Mubarak et al ., 2021). When sufficient Se is added, lipid peroxides in the cells will be decomposed to avoid peroxide reaction, and the process of cartilage internalisation of the bone can be completed, effectively preventing bone and joint deformation (Hou et al ., 2021).…”

Section: Physiological Functions Of Sementioning

confidence: 99%

Selenium and selenoproteins: their function and development of selenium‐rich foods

Han

Liu

2022

Int J of Food Sci Tech

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Summary Selenium (Se) is a nutrient related to human physiological processes and an essential trace element that has attracted considerable attention because of its antioxidant, immune and other functions. Se deficiency can cause all sorts of diseases and dysfunctions in the human tissues, but excessive intake of Se can also cause poisoning and injury. With lower toxicity and higher utilisation than inorganic Se, organic Se is recommended in the framework of a balanced diet. Compared with pharmaceutical supplementation, dietary Se supplementation is more acceptable to the masses. Thus, Se‐rich foods and selenoproteins enriched with organic Se have become a hot spot for current research. In living organisms, Se often exists in the form of selenoproteins (more than 25); for example, selenocysteine and selenomethionine are the common chemical forms of Se amino acids. And most of Se's physiological functions depend on the participation of selenoproteins. This paper reviews the physiological processes of Se, the development and utilisation of Se‐enriched foods, and the research on the properties of selenoproteins. Some suggestions and prospects for developing Se‐rich food in the future are also provided.

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“…Keshan disease (KD) is a primary endemic cardiomyopathy that only occurs in low-selenium areas from the northeast to the southwest in mainland China (1)(2)(3). Although KD has been effectively controlled in most endemic areas, new cases of chronic Keshan disease (CKD) and latent Keshan disease (LKD) still exist in some endemic areas with poor economic conditions (4).…”

Section: Introductionmentioning

confidence: 99%

A County-Level Spatial Study of Serum Selenoprotein P and Keshan Disease

Jia

Wang

et al. 2022

Front. Nutr.

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BackgroundKeshan disease (KD) is strongly associated with selenium deficiency. Selenoprotein P (SELENOP) is a recognized molecular biomarker of selenoproteins and an important indicator of selenium nutrition. This study was aimed at providing geographically precisely visualized evidence of selenium nutrition at molecular level for assessing KD prevention, control, and elimination on the etiological perspective.MethodsWe used spatial ecological design for this study. The serum SELENOP levels of the residents were measured by ELISA. ArcGIS version 9.0 was used for spatial description, spatial autocorrelation analysis of SELENOP levels and spatial regression with per capita disposable income.ResultsThe mean serum SELENOP levels of the 6,382 residents in 1,688 counties were 4.62 ± 1.82 μg/mL. The mean serum SELENOP levels of the residents living in the townships and rural areas of KD endemic counties were not statistically significantly lower than those of the KD non-endemic counties. The mean serum SELENOP levels were globally clustered (Moran's I = 0.03, z = 6.37, and P < 0.0001), and 99.3% (553/557) of the cold spots, identified by local autocorrelation analysis (Getis-Ord-Gi* analysis), were located in the KD endemic provinces of Shaanxi, Shanxi, Henan, Hebei, Shandong, Inner Mongolia, Gansu, Hubei, Chongqing, Yunnan, and Sichuan. The serum SELENOP level was positively correlated with per capita disposable income (t = 3.52, P = 0.0004).ConclusionsThe results of this study were the geographically precisely visualized evidence of selenium nutrition at molecular level for assessing KD elimination on the etiological perspective. The cold spot counties found by Getis-Ord-Gi* analysis in the KD endemic provinces should be the high priority of KD precision prevention and control.

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Association of selenium levels with the prevention and control of Keshan disease: A cross-sectional study

Cited by 22 publications

References 31 publications

Association between dietary selenium intake and bone mineral density in the US general population

Association between dietary selenium intake and bone mineral density in the US general population

Selenium and selenoproteins: their function and development of selenium‐rich foods

A County-Level Spatial Study of Serum Selenoprotein P and Keshan Disease

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