Association of <scp>KIR</scp> genes and <scp>HLA</scp>‐C alleles with <scp>HPV</scp>‐related uterine cervical disease in Korean women

Song, Min Jong; Lee, C. W.; Kim, J. H.; Lee, S. J.; Kim, C. J.; Hur, Soo-Young; Park, T. C.; Kim, T. G.; Park, J. S.

doi:10.1111/tan.12068

Cited by 11 publications

(17 citation statements)

References 34 publications

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“…Four casecontrol studies have previously examined the effects of variation at the HLA and KIR locus in women with CIN (2,5,6,10,11). In particular, Wang et al (11) and Martin et al (6) found that specific HLA ligands for inhibitory KIR were associated with modified risk of developing cervical neoplasia.…”

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confidence: 97%

“…In particular, Wang et al (11) and Martin et al (6) found that specific HLA ligands for inhibitory KIR were associated with modified risk of developing cervical neoplasia. Song et al (10) found HLA-C*0303 to confer susceptibility to HPV-related cervical disease, whereas HLA-C*01 was protective against HPV-related cervical disease. Our data are in agreement with the previous results on HLA-C group 1 allele involvement in HPV-associated lesion development (6), and are unique in that they were from an Italian population.…”

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confidence: 98%

“…However, the exact causes that lead to tumor have not been fully understood. Recent but few studies suggest a relationship between HLA-C alleles and HPV-related cervical diseases (2,6,5,10,11). Since we previously documented an important implication of natural killer (NK) cell inhibitory receptors (KIRs) and their interaction with HLA ligands in viral infection control in a cohort of multiple sclerosis patients (7), we focused our attention on HLA-C and KIR as possible reliable markers for HPV infection and lesion development in benign (condyloma acuminatum) and invasive cervical carcinoma (ICC).…”

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confidence: 99%

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Implication ofHLA-CandKIRAlleles in Human Papillomavirus Infection and Associated Cervical Lesions

RizzoRoberta

Gentili²,

RotolaAntonella³

et al. 2014

Viral Immunology

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Human papillomavirus (HPV) regulation of host immune response leads to cervical lesions. In particular, natural killer (NK) cells are crucial for HPV control. Since specific HLA-I/KIR interactions modify NK cell activation, we analyzed HLA-C and KIR alleles in HPV infection and lesion development in 150 controls, 33 condyloma acuminatum, and 111 invasive cervical cancer (ICC) patients. We showed an increase in HLA-C1/KIR2DL2 and HLA-C1/KIR2DL3 pairs in HPV high-risk infected patients (OR 3.05, 3.24) with ICC (OR 1.33, 3.68). These data suggest HLA-C and KIR typing as risk marker for HPV infection and lesion evolution.

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confidence: 97%

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confidence: 98%

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confidence: 99%

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Implication ofHLA-CandKIRAlleles in Human Papillomavirus Infection and Associated Cervical Lesions

RizzoRoberta

Gentili²,

RotolaAntonella³

et al. 2014

Viral Immunology

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“…Other class I alleles that have shown to decrease HPV-associated cervical disease are: HLA-B*14 [39], B*2705 [43], HLA-B*3503, B*40, B*4006, B*52 [41], HLA-Cw*0202 and HLA-Cw*0401 [43], HLA-C*03 [40], HLA-G*0103 [47], HLA-C*01 [45], and HLA-C*08 [39] (Fig. 3).…”

Section: Discussionmentioning

confidence: 99%

“…3). The alleles HLA-B*3503 and HLA-C*0303 have shown contradictory results, and more information is needed to characterize the true role of these alleles in the outcome of HPV infections [40, 41, 43, 45]. …”

Section: Discussionmentioning

confidence: 99%

From HPV Infection to Lesion Progression: The Role of HLA Alleles and Host Immunity

et al. 2019

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Persistent high-risk human papillomavirus (HPV) infection has been associated with increased risk for cervical precancerous lesions and cancer. The host’s genetic variability is known to play a role in the development of cervical cancer. The human leukocyte antigen (HLA) genes are highly polymorphic and have shown to be important risk determinants of HPV infection persistence and disease progression. HLA class I and II cell surface molecules regulate the host’s immune system by presenting HPV-derived peptides to T-cells. The activation of T-cell response may vary depending on the HLA allele polymorphism. The engagement of the T-cell receptor with the HPV peptide-HLA complex to create an active costimulatory signal is essential for the activation of the T-cell response. Functional peptide presentation by both HLA class I and II molecules is needed to activate efficient helper and effector T-cell responses in HPV infection recognition and clearance. Some of these HLA risk alleles could also be used as preventive tools in the detection of HPV-induced cervical lesions and cancer. These HLA alleles, together with HPV vaccines, could potentially offer possible solutions for reducing HPV-induced cervical cancer as well as other HPV-related cancers.

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Killer cell immunoglobulin‐like receptor (KIR) gene contents: Are they associated with cervical cancer?

Tembhurne

Maheshwari

Warke

et al. 2022

Journal of Medical Virology

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Killer cell immunoglobulin‐like receptors (KIRs) are required for natural killer cell function against virus‐infected cells or tumor cells. KIR gene content polymorphisms in Indian women with cervical cancer (CaCx) remain unexplored. Hence, we analyzed the frequencies of KIR genes, KIR haplotypes, and Bx subsets to draw their association with CaCx. The polymerase chain reaction‐sequence‐specific primer method was used for KIR genotyping in three groups of women: healthy controls (n = 114), women with human papillomavirus (HPV) infection (n = 70), and women with CaCx (n = 120). The results showed that the frequency of KIR2DS5 was significantly higher in women with CaCx compared to women with HPV infection (p = 0.02) and healthy controls (p = 0.01). Whereas the frequency of KIR2DL5B was significantly higher in healthy controls than in women with HPV infection (p = 0.02). The total number of activating KIR genes was higher in women with CaCx than in healthy controls (p = 0.006), indicating their positive association with CaCx. Moreover, the C4T4 subset was higher in women with CaCx than in women with HPV infection, though not significant. In conclusion, our findings highlight KIR2DS5, the C4T4 subset, and activating KIR genes are susceptible factors or positively associated with CaCx. Besides KIR2DL5B, this study also reported for the first time significantly high frequency of KIR2DL1 in healthy controls, indicating its possible protective association against CaCx. Further, significantly high frequency of KIR2DL3 observed in HPV‐infected women might be also a promising biomarker for viral infections. Thus, the study confirms the association of KIR genes with cervical cancer in women with HPV infection.

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Association of KIR genes and HLA‐C alleles with HPV‐related uterine cervical disease in Korean women

Cited by 11 publications

References 34 publications

Implication ofHLA-CandKIRAlleles in Human Papillomavirus Infection and Associated Cervical Lesions

Implication ofHLA-CandKIRAlleles in Human Papillomavirus Infection and Associated Cervical Lesions

From HPV Infection to Lesion Progression: The Role of HLA Alleles and Host Immunity

Killer cell immunoglobulin‐like receptor (KIR) gene contents: Are they associated with cervical cancer?

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