Association of<scp>HLA</scp>‐B*27 with ankylosing spondylitis in Kurdish patients

Al-Qadi, Rawand; Salih, Saadallah Fareeq; AlDoski, Heleen Jalal; Nabeel, Mariam; Ali, Jumaa Hussein; Khasho, Djwar Ali; Yaqo, Rafil T.

doi:10.1111/1756-185x.12605

Cited by 6 publications

(10 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Among the extra-articular manifestations, anterior uveitis was the most commonly reported, with a rate of 7.1% in this study, which was similar to that reported among Moroccans (6.8%) [9] and Saudis (7%) [14] but lower than that reported in Jordanians (13%) [16], Kurdish (12.2%) [30], Iranians (44.9%) [23] and those living in Qatar (14.5%) [15].…”

Section: Discussionsupporting

confidence: 85%

Characterization of ankylosing spondylitis in Upper Egypt

Moshrif¹,

Mosallam²,

Rayan³

et al. 2018

ISSN 1758-4272 Int. J. Clin. Rheumatol

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 85%

Characterization of ankylosing spondylitis in Upper Egypt

Moshrif¹,

Mosallam²,

Rayan³

et al. 2018

ISSN 1758-4272 Int. J. Clin. Rheumatol

View full text Add to dashboard Cite

“…(1) assessed the association between K. pneumoniae infection and AS; (2) cohort studies or case-control studies; (3) the K. pneumoniae infections were defined as positive by antibody tests, DNA tests, and isolation and cultivation of bacteria; (4) reporting of corresponding effect estimates (eg, relative risk or odds ratio [OR]) or sufficient data to use in calculations; (5) published in English or Chinese. When there were multiple publications from the same population during an overlapping time period, data from the most recent or comprehensive study were used.…”

Section: Inclusion and Exclusion Criteriamentioning

confidence: 99%

“…2 Genetic factors are thought to be related to AS. [3][4][5][6][7][8] It has been reported that more than 90% of AS patients carry the human leukocyte antigen (HLA)-B27 gene. 9Enterobacteria infection, 10 such as with Klebsiella pneumoniae, Proteus mirabilis, Escherichia coli, was deemed in previous studies to be another risk factor causing AS.Among Enterobacteria, K. pneumoniae has received the most attention.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Association between Klebsiella pneumoniae and ankylosing spondylitis: A systematic review and meta‐analysis

Long

Wang

et al. 2022

Int J of Rheum Dis

View full text Add to dashboard Cite

Aim The aim of this study is to evaluate the association between Klebsiella pneumoniae infection and ankylosing spondylitis (AS). Method Five electronic databases, PubMed, Embase, Medline, Web of Science, and Scopes, were searched until September 29, 2021. Cohort and case‐control studies that assessed the association between K. pneumoniae infection and AS were included. Pooled odds ratio (OR) was selected to show the effect size. Subgroup analysis (active or inactive AS) and 2 forms of sensitivity analysis were conducted. All statistical analyses were conducted by using STATA 12.0. Results There were 25 case‐control studies finally included, including 8 studies concerning presence of K. pneumoniae in feces, and 17 studies concerning serum antibody (immunoglobulin [Ig]G, IgM, IgA) against K. pneumoniae. The results suggested that when compared with healthy people, presence of K. pneumoniae in feces was associated with AS (OR: 5.65; 95% CI: 1.68‐19.00). Similarly, when compared with healthy people, higher positive rates of IgA (OR: 6.28; 95% CI: 3.32‐11.91) and IgG (OR: 5.22; 95% CI: 1.36‐19.99) were observed. Subgroup analyses suggested that association between K. pneumoniae and AS appears stronger in active AS. Conclusion When compared with healthy people, a significantly higher positive rate of K. pneumoniae in feces, serum IgA and IgG were observed in patients with AS, suggesting that K. pneumoniae probably plays a crucial role in the occurrence of AS. The findings in this study need further prospective investigations for confirmation.

show abstract

“…A study of samples in the Kurdistan region of Iraq showed that the ratio of males to females was 5.8:1 (7). It was also reported that the peak age range for onset is 15-35 years (5).…”

Section: Introductionmentioning

confidence: 99%

Serum levels of CXCL-8, IL-10, and TNF-alpha in ankylosing spondylitis patients

Karim¹

2021

Biomedicine

View full text Add to dashboard Cite

The mean age of AS patients was (35.0 ± 9.8) years.When the patients and control subjects were divided into different age groups (>40, 30-40, <30 years), the differences were not significantin terms of disease prevalence. The results also showed that the percentage of male patients is higher than that of females. There was no significant difference (P?0.05) between patients and controls in the distribution of males and females.Most of the patients had the disease for a period of 5 years or higher, with a disease severity of ? 2.1 and functional disability degree of I, II. The resultsshoweddifferent patterns of distribution for the three tested cytokines. A significant increase in the level of TNF-?, anon-significantincrease in the level of CXCL-8, and a significant decrease in the level of IL-10 were observed in the sera of patients with AS compared with the control.The patients also demonstrated significant decreases in the serum ALT and AST enzyme levels, hemoglobin (Hb) level, white blood cells (WBC) count, and erythrocyte sedimentation rate (ESR) (P?0.05).The percentage of HLA-B27-positive Iraqi patients was lower than that of the HLA-B27-negative patients. Some of these patterns were also exposed to changes related to some determinants in patients, which included age, sex, disease duration, disease severity, functional disability, and HLA-B27 positivity,along with association with clinical subtypes of AS.The area under the curve was determined for the parameters of ESR, IL-10, TNF-? and CXCL-8.The most significant factor was found to beESR, followed by IL-10, and then TNF-?, with the presence of significant differences, while there was no diagnostic significance for CXCL-8 ,which showed no significant difference (p?0.05).

show abstract

Association ofHLA‐B*27 with ankylosing spondylitis in Kurdish patients

Abstract: From this study, we can conclude that the prevalence of HLA-B27 among the Kurdish healthy population is 3.8% and there is a strong association between HLA-B27 and ankylosing spondylitis patients in the Kurdistan Region of Iraq.

Cited by 6 publications

References 29 publications

Characterization of ankylosing spondylitis in Upper Egypt

Characterization of ankylosing spondylitis in Upper Egypt

Association between Klebsiella pneumoniae and ankylosing spondylitis: A systematic review and meta‐analysis

Serum levels of CXCL-8, IL-10, and TNF-alpha in ankylosing spondylitis patients

Contact Info

Product

Resources

About

Association ofHLA‐B*27 with ankylosing spondylitis in Kurdish patients

Abstract: From this study, we can conclude that the prevalence of HLA-B*27 among the Kurdish healthy population is 3.8% and there is a strong association between HLA-B*27 and ankylosing spondylitis patients in the Kurdistan Region of Iraq.

Cited by 6 publications

References 29 publications

Characterization of ankylosing spondylitis in Upper Egypt

Characterization of ankylosing spondylitis in Upper Egypt

Association between Klebsiella pneumoniae and ankylosing spondylitis: A systematic review and meta‐analysis

Serum levels of CXCL-8, IL-10, and TNF-alpha in ankylosing spondylitis patients

Contact Info

Product

Resources

About

Abstract: From this study, we can conclude that the prevalence of HLA-B27 among the Kurdish healthy population is 3.8% and there is a strong association between HLA-B27 and ankylosing spondylitis patients in the Kurdistan Region of Iraq.