Association of sarcopenia with functional decline in community‐dwelling elderly subjects in <scp>J</scp>apan

Tanimoto, Yoshimi; Watanabe, Misuzu; Sun, Wei; Tanimoto, Keiji; Shishikura, Kanako; Sugiura, Yumiko; Kusabiraki, Toshiyuki; Kono, Koichi

doi:10.1111/ggi.12037

Cited by 112 publications

(95 citation statements)

References 20 publications

(69 reference statements)

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“…Patients with sarcopenia show a worse swallowing ability and a lower nutritional status than those without it. Furthermore, older men (>65 years of age) with sarcopenia showed lower ADL values than patients without sarcopenia (7,8).…”

Section: Discussionmentioning

confidence: 90%

“…Other recent studies have revealed that sarcopenia is a risk factor for postoperative complications or a poor survival in some solid cancers. For stage 2-3 gastric cancer, patients with sarcopenia showed a higher rate of postoperative complications and a poorer overall and recurrence-free survival than those without sarcopenia (8,11). Pancreatic cancer patients with sarcopenia who underwent pancreatectomy also showed a poorer overall survival than the patients without sarcopenia (12).…”

Section: Discussionmentioning

confidence: 98%

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A low psoas muscle volume predicts longer hospitalization and cancer recurrence in upper urinary tract urothelial carcinoma

et al. 2017

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 98%

A low psoas muscle volume predicts longer hospitalization and cancer recurrence in upper urinary tract urothelial carcinoma

et al. 2017

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“…Ideally, specific cutoff points for sarcopenia should be determined for each specific patient population and race. There have been a few reports that defined a cutoff point for sarcopenia in Japanese [31,32]. Based on these studies, we defined the cutoff point as the gender-specific 20th percentile in this study.…”

Section: Discussionmentioning

confidence: 99%

Impact of preoperative hand grip strength on morbidity following gastric cancer surgery

et al. 2015

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Background Sarcopenia is a decrease in both muscle mass and strength. It remains unclear whether sarcopenia is associated with morbidity after gastric cancer surgery. This study evaluated the impact of sarcopenia on the morbidity of gastric cancer surgery. Methods A total of 293 gastric cancer patients who underwent curative surgery between May 2011 and June 2013 were retrospectively examined. Patients with performance status 3 or 4 were excluded. Preoperative lean body mass (LBM) was evaluated by bioelectrical impedance analysis and expressed as LBM index. Preoperative muscle function was measured by hand grip strength (HGS). The cutoff values were the gender-specific lowest 20 %. Grade 2 or higher morbidities, as retrospectively evaluated by the Clavien-Dindo classification, were obtained from the patient record. The risk factors for morbidity were examined by univariate and multivariate analyses. Results Morbidity was observed in 39 patients (13.3 %), including 7 with pancreatic leakage, 12 with anastomotic leakage, and 4 with intraabdominal abscesses, but no mortality was observed. The univariate analysis showed that male gender, total gastrectomy, splenectomy, and a low HGS were significant risk factors for morbidity. A low LBM was not a significant risk factor. A low HGS, male gender, and total gastrectomy remained significant in the multivariate analysis. Conclusions A low hand grip strength was a significant risk factor for morbidity after gastric cancer surgery. The importance of the hand grip strength as a risk factor should be examined in future prospective studies.

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“…Muscle mass decreases by about 25% from the age of 50 to about 75 compared to the amount of muscle at the age of 20 and physical abilities such as balance and flexibility noticeably decrease [28,29]. Due to this deterioration of physical functions, the risk of falling increases and falls increase the risk of fracture [30,31], causing a vicious cycle in which hypoactivity causes amyotrophia [32]. It has been reported in many studies that there is a positive correlation between BMD and exercise.…”

Section: Discussionmentioning

confidence: 99%

Characteristics of nutrient intakes, basal physical fitness and serum markers in elderly women with osteopenia

Kim¹,

Kim

Hong³

et al. 2015

J. Exerc. Nutr, Biochem.

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of nutrient intakes, basal physical fitness and serum markers in elderly women with osteopenia. JENB., Vol. 19, No. 3, pp.217-224, 2015 [Purpose] This study investigated the correlations among BMD, nutrient intake, basal physical fitness and serum markers in elderly women with osteopenia.[Methods] Bone Mineral Density (BMD) was measured in 54 elderly women (60-77yrs) by using dual energy X-ray absorptiometry (DEXA). The subjects were divided into an osteopenia group (OG; n = 29) and a normal group (NG; n = 25). A physical fitness test was conducted to determine muscle strength, muscle endurance, flexibility, agility, and balance. The dietary nutrient intake for one day was analyzed. The serum Ca, Pi and Mg concentration was also analyzed.[Results] There was significant correlation between All subject's weight and their total-BMD as well as the T-score (p < .01). There was also significant correlation between the fat free mass and Total-BMD (p < .01). There was significant positive correlation between energy intake and dietary carbohydrate with Total-BMD and T-score in the OG (p < .05). The Serum Pi of the OG was significantly lower than that of the NG (p < .05), and there was significant correlation with the BMD in most regions as well as with the Total-BMD and T-score (p < .05, p < .01).[Conclusion] These results suggested that the fat free mass in elderly women plays an important role in maintaining their BMD and that sufficient caloric intake would be likely to improve BMD in elderly women with osteopenia. In addition, the results suggested the possibility of a decrease in bone mass by hypophosphatemia in elderly women.

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Association of sarcopenia with functional decline in community‐dwelling elderly subjects in Japan

Abstract: Sarcopenia, defined by muscle mass, muscle strength and physical performance, was associated with functional decline over a 2-year period in elderly Japanese. Interventions to prevent sarcopenia are very important to prevent functional decline among elderly individuals.

Cited by 112 publications

References 20 publications

A low psoas muscle volume predicts longer hospitalization and cancer recurrence in upper urinary tract urothelial carcinoma

A low psoas muscle volume predicts longer hospitalization and cancer recurrence in upper urinary tract urothelial carcinoma

Impact of preoperative hand grip strength on morbidity following gastric cancer surgery

Characteristics of nutrient intakes, basal physical fitness and serum markers in elderly women with osteopenia

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