Association of Salivary Helicobacter pylori Infection with Oral Diseases: a Cross-sectional Study in a Chinese Population

Abstract

Objective: The aim of this study was to detect the prevalence of oral H.pylori among adults and to investigate the correlation between H.pylori infection and common oral diseases.Study design: A cross-sectional study was performed among adults Chinese who took their annual oral healthy examination at The First Affiliated Hospital, Zhejiang University School of Medicine, China.Results: The study included 1050 subjects in total and oral H.pylori infection occurred in 60.29% of the subjects. The prevalence rates of oral H.pylori in patients with periodontal diseases (63.42%) and caries (66.91%) were significantly increased than those without oral diseases (54.07%), respectively (P < 0.05), while the difference between subjects with recurrent aphthous stomatitis and controls was not significant. In addition, the differences of positive rates of H.pylori with or without history of gastric ulcer were statistically significant (69.47% vs 58.26%, P<0.05). Presenting with periodontal diseases (OR 1.473;95% CI 1.021 to 2.124), caries (OR 1.717; 1.127 to 2.618), and having history of gastric ulcer (OR 1.631; 1.164 to 2.285) increased the risk of H.pylori infection.Conclusions: Oral H.pylori infection is common in adult Chinese, which is significantly associated with oral diseases including periodontal diseases and caries.

Two-Way Relationship Between Helicobacter Pylori Infection and Periodontitis: Results from A Systematic Review and Meta-Analysis

“…Diverse ethnical groups composed the studies and the patients were enrolled both in a Hospital-based population and a Community-based population [12,[24][25][26][33][34][35][36][37][38][39]. The studies used four types of diagnosis methods for H. pylori detection: Rapid Urease test (RUT) Serological test to antibody against the bacteria Polymerase Chain Reaction (PCR) and saliva H. pylori antigen test (HPS) [12,24,25,[33][34][35][37][38][39]. Tree studies focused in to assess the H. pylori infection as potential risk factor for periodontitis [12,24,33].…”

“…The studies used four types of diagnosis methods for H. pylori detection: Rapid Urease test (RUT) Serological test to antibody against the bacteria Polymerase Chain Reaction (PCR) and saliva H. pylori antigen test (HPS) [12,24,25,[33][34][35][37][38][39]. Tree studies focused in to assess the H. pylori infection as potential risk factor for periodontitis [12,24,33]. On the other hand, eight studies were conducted to clarify the periodontitis as risk factor for H. pylori infection [25,26,[34][35][36][37][38][39].…”

“…pylori infection also was associated with several others extra gastric conditions [8]. Studies available in literature report the relationship among H. pylori infection and heart failure hepatic insulin resistance pregnancy-related disorders and oral diseases [9][10][11][12]. Results from a meta-analysis showed a significant association between halitosis and H. pylori present in stomach with an Odds Ratio value of 4.03 [13].…”

A Clinical and Microbiological Evaluation of Helicobacter pylori in Recurrent Aphthous Stomatitis

“…5 There are limited data regarding the relevancy of RAS and H. pylori infection. Hence, this study was undertaken to comparatively evaluate the association of H. pylori in RAS and in patients with peptic ulcer.…”

“…1 Helicobacter pylori is a Gram-negative, microaerophilic, spiral-shaped bacteria found in the mucosa of the gastric region. 1,2,5 Infection of H. pylori is serious, transmissible, and associated with peptic and duodenal ulcers, gastric carcinoma, and non-Hodgkin's lymphomas of gastric mucosa related with lymphoid tissue. It has been observed from the earlier studies that these bacteria infected 20 to 30% of adult people in developed countries and more than 90% of them in the developing countries.…”