Association of rs2294008 and rs9297976 Polymorphisms in PSCA Gene with Gastric Cancer Susceptibility in Uzbekistan

Turdikulova, Shahlo; Dalimova, Dilbar; Abdurakhimov, Abror; Adilov, B. Sh.; Navruzov, S.; Yusupbekov, Abror; Djuraev, M.; Abdujapparov, S.B.; Egamberdiev, D.; Mukhamedov, Rustam

doi:10.5195/cajgh.2016.227

Cited by 7 publications

(5 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Section: Introductionsupporting

confidence: 66%

“…The study analyzed 925 DGC cases with 1396 controls and reported a strong association with the T allele at rs2294008 in PSCA. This association has also been observed in other populations across the world including Koreans [7,8], Uzbekistanis [9], and even Caucasians [10][11][12]. rs2294008 is located in the upstream region of PSCA, and a T to C transition at this single nucleotide polymorphism (SNP) causes a missense mutation (ATG to ACG) at the presumed translation-initiating codon in the first exon, resulting in a nine-amino-acid truncation of its signal peptide.…”

Section: Introductionmentioning

confidence: 68%

See 1 more Smart Citation

Evolutionary History of the Risk of SNPs for Diffuse-Type Gastric Cancer in the Japanese Population

Iwasaki

Ishiya

Kanzawa-Kiriyama

et al. 2020

Genes

View full text Add to dashboard Cite

A genome wide association study reported that the T allele of rs2294008 in a cancer-related gene, PSCA, is a risk allele for diffuse-type gastric cancer. This allele has the highest frequency (0.63) in Japanese in Tokyo (JPT) among 26 populations in the 1000 Genomes Project database. FST ≈ 0.26 at this single nucleotide polymorphism is one of the highest between JPT and the genetically close Han Chinese in Beijing (CHB). To understand the evolutionary history of the alleles in PSCA, we addressed: (i) whether the C non-risk allele at rs2294008 is under positive selection, and (ii) why the mainland Japanese population has a higher T allele frequency than other populations. We found that haplotypes harboring the C allele are composed of two subhaplotypes. We detected that positive selection on both subhaplotypes has occurred in the East Asian lineage. However, the selection on one of the subhaplotypes in JPT seems to have been relaxed or ceased after divergence from the continental population; this may have caused the elevation of T allele frequency. Based on simulations under the dual structure model (a specific demography for the Japanese) and phylogenetic analysis with ancient DNA, the T allele at rs2294008 might have had high frequency in the Jomon people (one of the ancestral populations of the modern Japanese); this may explain the high T allele frequency in the extant Japanese.

show abstract

Section: Introductionsupporting

confidence: 66%

Section: Introductionmentioning

confidence: 68%

Evolutionary History of the Risk of SNPs for Diffuse-Type Gastric Cancer in the Japanese Population

Iwasaki

Ishiya

Kanzawa-Kiriyama

et al. 2020

Genes

View full text Add to dashboard Cite

show abstract

“…In Asia, the prevalence of Helicobacter pylori ( H. pylori ) is found as an important etiological factor for the development of gastric cancer [4]. In addition, previous studies showed that the potential environmental factors associated with gastric cancer might include tobacco smoking, alcohol use, dietary habits, unrefined vegetable oil, intake of water and daily consumption of meat-broth [5,6]. Furthermore, genetic factors have been also found to play an important role in the development of gastric cancer.…”

Section: Introductionmentioning

confidence: 99%

Impact of PSCA gene polymorphisms in modulating gastric cancer risk in the Chinese population

Yan

Lin

et al. 2019

Bioscience Reports

View full text Add to dashboard Cite

Previous studies have identified the prostate stem cell antigen (PSCA) gene rs2294008 C > T and rs2976392 G > A polymorphisms to be associated with the risk of gastric cancer, the results of which are inconsistent. The present study aimed to evaluate the association between the two polymorphisms and the gastric cancer risk in the Chinese population. A hospital-based case–control study was conducted on 549 cases and 592 healthy controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were applied to evaluate the association of the two polymorphisms on the gastric cancer risk. We found that both rs2294008 (CT vs. CC, OR = 1.55, 95% CI = 1.20–1.99, P<0.001 and CT+TT vs. CC, OR = 1.38, 95% CI = 1.09–1.74, P=0.008) and rs2976392 (GA vs. GG, OR = 1.61, 95% CI = 1.25–2.07, P<0.001 and GA+AA vs. GG, OR = 1.52, 95% CI = 1.20–1.92, P<0.001) were associated with an increased gastric cancer. In the combined analysis of the two polymorphisms, subjects with more than one risk genotype have a significantly increased risk of gastric cancer (OR = 1.38, 95% CI = 1.09–1.75, P=0.008) in comparison with those without any risk genotypes. In conclusion, our findings verified that the PSCA gene rs2294008 and rs2976392 polymorphisms were both significantly associated with an increased risk of gastric cancer in the Chinese population. Well-designed functional studies are to be warranted to confirm these findings.

show abstract

“…On the other hand, CA haplotype between rs2294008C/T and rs2976392A/G is associated with a significant reduction in gastric cancer in Tebyan population [ 86 ]. The role of rs2294008 and rs2976392 in the incidence of cancer in Uzbekistan has also been investigated and the results indicate that the rs2294008 T allele is associated with an increased risk of GC and rs2976392 located in intron 2 has a significant association with GC in women under 40 years of age [ 87 ].…”

Section: Psca Expression and Polymorphisms In Different Cancersmentioning

confidence: 99%

Significance of PSCA as a novel prognostic marker and therapeutic target for cancer

Nayerpour Dizaj,

Doustmihan,

Sadeghzadeh Oskouei

et al. 2024

Cancer Cell Int

View full text Add to dashboard Cite

One of the contributing factors in the diagnosis and treatment of most cancers is the identification of their surface antigens. Cancer tissues or cells have their specific antigens. Some antigens that are present in many cancers elicit different functions. One of these antigens is the prostate stem cell antigen (PSCA) antigen, which was first identified in the prostate. PSCA is a cell surface protein that has different functions in different tissues. It can play an inhibitory role in cell proliferation as well as a tumor-inducing role. PSCA has several genetic variants involved in cancer susceptibility in some tissues, so identifying the characteristics of this antigen and its relationship with clinical features can provide more information on diagnosis and treatment of patients with cancers. Most studies on the PSCA have focused on prostate cancer. While it is also expressed in other cancers, little attention has been paid to its role as a valuable diagnostic, prognostic, and therapeutic tool in other cancers. PSCA has several genetic variants that seem to play a significant role in cancer susceptibility in some tissues, so identifying the characteristics of this antigen and its relationship and variants with clinical features can be beneficial in concomitant cancer therapy and diagnosis, as theranostic tools. In this study, we will review the alteration of the PSCA expression and its polymorphisms and evaluate its clinical and theranostics significance in various cancers.

show abstract

Association of rs2294008 and rs9297976 Polymorphisms in PSCA Gene with Gastric Cancer Susceptibility in Uzbekistan

Cited by 7 publications

References 24 publications

Evolutionary History of the Risk of SNPs for Diffuse-Type Gastric Cancer in the Japanese Population

Evolutionary History of the Risk of SNPs for Diffuse-Type Gastric Cancer in the Japanese Population

Impact of PSCA gene polymorphisms in modulating gastric cancer risk in the Chinese population

Significance of PSCA as a novel prognostic marker and therapeutic target for cancer

Contact Info

Product

Resources

About