Association of RS2200733 but Not RS10033464 on 4q25 with Atrial Fibrillation Based on the Recessive Model in a Taiwanese Population

Abstract

Objectives: To determine the association between genetic variants on chromosome 4q25 and atrial fibrillation (AF) in a Taiwanese population. Methods: We enrolled 200 patients with AF (mean age: 67 ± 13 years) and 158 controls (mean age: 63 ± 10 years). The genotypes of five SNPs, RS2634073, RS2200733, RS13143308, RS2220427 and RS10033464, were determined using multiplex single base extension methods. Results: The distribution of the RS2200733 and RS10033464 genotypes did not significantly deviate from the Hardy-Weinberg equilibrium in the control group. The distribution of the RS2200733 genotypes differed significantly between the AF group and the controls (p = 0.03), whereas the distribution of the RS10033464 genotypes did not (p = 0.49). At RS2200733, patients with the CC genotype exhibited a 0.45 times higher risk of developing AF than those with the TT genotype (p = 0.02) and a recessive model was suggested (p = 0.01). After adjusting for various covariates, patients with the CC genotype remained recessively associated with a lower risk of developing AF than those with the TT genotype (odds ratio: 0.27, 95% confidence interval: 0.11–0.65; p < 0.01). Conclusions: In the Taiwanese, there is an association between SNP RS2200733 – but not RS10033464 – and the development of AF. Based on a recessive model of inheritance, individuals with SNP RS2200733 genotype CC are at a lesser risk of developing AF.

Next-generation sequencing of nine atrial fibrillation candidate genes identified novel de novo mutations in patients with extreme trait of atrial fibrillation

“…The genes most closely linked to these risk variants are KCNN3, PRRX1, PITX2, WNT8A, CAV1, C9orf3, SYNE2, HCN4 and ZFHX3 2–4. Among them, variants near the PITX2 gene show the strongest association with AF; an association that has been independently replicated in other ethnic populations, including our Taiwanese population 5. An association of KCNN3 with AF was also found in our Taiwanese population 6.…”

Can Polymorphisms Predict Response to Antiarrhythmic Drugs in Atrial Fibrillation?

“…(5) Subsequent studies have found a strong association for rs2200733 than for rs10033464. (6) (7) (8) Two additional SNPs on chromosomes 1q21 and 16q22 with modest effects have also been identified. (9) (10)…”

Common variants for atrial fibrillation: results from genome-wide association studies

“…In addition, Lee et al examined the genotypes of Wve singlenucleotide polymorphisms (SNPs), rs2634073, rs2200733, rs13143308, rs2220427 and rs10033464 in a Taiwanese population composed of 200 AF patients and 158 healthy controls using multiplex single base extension methods. They conWrmed the association between rs2200733 and AF, but failed to conWrm the association between rs10033464 and AF (Lee et al 2010). In sum, these studies consistently showed the association between rs2200733 and AF but not with rs10033464.…”