Association of risk variants for type 2 diabetes and hyperglycemia with gestational diabetes

Huopio, Hanna; Cederberg, Henna; Vangipurapu, Jagadish; Hakkarainen, Heidi; Pääkkönen, Mirja; Kuulasmaa, Teemu; Heinonen, Seppo; Laakso, Markku

doi:10.1530/eje-13-0286

Cited by 108 publications

(105 citation statements)

References 38 publications

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“…The BMI, age, and HbA1c parameters of pregnant women in the groups in question were similar to those in pregnant women in groups of similar studies (Huopio et al, 2013;Takhshid and Zare, 2015).…”

Section: Discussionsupporting

confidence: 68%

Leptin (rs7799039) and solute carrier family 30 zinc transporter (rs13266634) polymorphisms in Euro-Brazilian pregnant women with gestational diabetes

et al. 2017

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ABSTRACT. Leptin (LEP), a protein that plays a fundamental role in the metabolism of energy reserves, and the solute carrier family 30 A8 zinc transporter (SLC30A8) have been consistently associated with diabetes. Women with gestational diabetes are at moderate risk of developing diabetes type 1 and 2 after pregnancy, in addition to complications to the fetus. We investigated the association of the polymorphisms rs7799039 (LEP) and rs13266634 (SLC30A8) in a case-control study in Euro-Brazilians with gestational diabetes (GDM, N = 180). Realtime PCR with fluorescent probes (TaqMan system) was applied to genotyping. All polymorphisms were in Hardy-Weinberg equilibrium. The minor allele frequencies, for healthy and GDM, respectively, for the A-allele (LEP gene rs7799039) were 40.3% (95%CI = 35-45%) vs 36.6% (95%CI = 31-42%), P = 0.345; and for the T-allele (SLC30A8 gene rs13266634) were 27.8% (95%CI = 23-32%) vs 23.5% (95%CI = 18-29%), P = 0.227. Genotype comparisons for both polymorphisms showed no significant difference (P > 0.05). The polymorphisms rs7799039 and rs13266634 were not associated with GDM in the population studied (P > 0.05). The minor allele frequencies for both polymorphisms were similar to those of other Caucasian populations.

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Section: Discussionsupporting

confidence: 68%

Leptin (rs7799039) and solute carrier family 30 zinc transporter (rs13266634) polymorphisms in Euro-Brazilian pregnant women with gestational diabetes

et al. 2017

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“…Independent genome-wide association studies in European populations identified single nucleotide polymorphisms near MTNR1B that were associated with fasting plasma glucose, reduced beta cell function, and significantly increased T2DM risk: rs1387153 and rs10830963. 104, 105 Expression of these two single nucleotide polymorphisms is also significantly associated with the development of gestational diabetes, 106, 107 as well as elevated fasting glucose and reduced insulin secretion after parturition. 106 A diagnosis of gestational diabetes is one of the highest predictors for the later development of T2DM.…”

Section: The Mt2 Receptor: Targeting Dysregulated Insulin Secretion Amentioning

confidence: 99%

Inhibitory G proteins and their receptors: emerging therapeutic targets for obesity and diabetes

et al. 2014

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The worldwide prevalence of obesity is steadily increasing, nearly doubling between 1980 and 2008. Obesity is often associated with insulin resistance, a major risk factor for type 2 diabetes mellitus (T2DM): a costly chronic disease and serious public health problem. The underlying cause of T2DM is a failure of the beta cells of the pancreas to continue to produce enough insulin to counteract insulin resistance. Most current T2DM therapeutics do not prevent continued loss of insulin secretion capacity, and those that do have the potential to preserve beta cell mass and function are not effective in all patients. Therefore, developing new methods for preventing and treating obesity and T2DM is very timely and of great significance. There is now considerable literature demonstrating a link between inhibitory guanine nucleotide-binding protein (G protein) and G protein-coupled receptor (GPCR) signaling in insulin-responsive tissues and the pathogenesis of obesity and T2DM. These studies are suggesting new and emerging therapeutic targets for these conditions. In this review, we will discuss inhibitory G proteins and GPCRs that have primary actions in the beta cell and other peripheral sites as therapeutic targets for obesity and T2DM, improving satiety, insulin resistance and/or beta cell biology.

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“…Among these, the risk allele (G) of rs10830963 in the melatonin receptor 1B (MTNR1B) gene (MTNR1B) shows the highest OR for GDM in a Finnish study [4].…”

Section: Introductionmentioning

confidence: 99%

Interaction between rs10830963 polymorphism in MTNR1B and lifestyle intervention on occurrence of gestational diabetes

et al. 2016

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Aims/hypothesis The aim of this study was to assess the interaction between melatonin receptor 1B gene (MTNR1B) rs10830963 polymorphism and lifestyle intervention during pregnancy on occurrence of gestational diabetes mellitus (GDM) in high-risk women. Methods This is a secondary analysis of the randomised controlled gestational diabetes prevention trial 'RADIEL', conducted between 2008 and 2014 in four maternity hospitals in southern Finland. A total of 226 women with a history of GDM and/or a pre-pregnancy BMI ≥ 30 kg/m 2 were enrolled at <20 weeks of gestation (mean 13 weeks) and randomised into an intervention group receiving counselling on diet, physical activity and weight control and a control group receiving standard antenatal care. The main outcome was incidence of GDM, defined as one or more pathological glucose values in a standard 75 g 2-h OGTT. The MTNR1B rs10830963 was genotyped for further analyses.Results No significant differences were found in the genotype distribution between the intervention and the control group. A significant interaction was observed between the rs10830963 genotypes and the lifestyle intervention on age-adjusted occurrence of gestational diabetes (p = 0.038). Among women homozygous for the C allele of rs10830963, the OR for GDM was significantly lower in the intervention group than in the control group (OR 0.

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Association of risk variants for type 2 diabetes and hyperglycemia with gestational diabetes

Abstract: Our study suggests that GDM and T2D share a similar genetic background. Our findings also provide further evidence that risk variants of MTNR1B are associated with GDM by increasing fasting plasma glucose and decreasing insulin secretion.

Cited by 108 publications

References 38 publications

Leptin (rs7799039) and solute carrier family 30 zinc transporter (rs13266634) polymorphisms in Euro-Brazilian pregnant women with gestational diabetes

Leptin (rs7799039) and solute carrier family 30 zinc transporter (rs13266634) polymorphisms in Euro-Brazilian pregnant women with gestational diabetes

Inhibitory G proteins and their receptors: emerging therapeutic targets for obesity and diabetes

Interaction between rs10830963 polymorphism in MTNR1B and lifestyle intervention on occurrence of gestational diabetes

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