Association of Rhizophora mangle and ascorbic acid in hydrogels: Evaluation of cytotoxic and immunomodulatory effects
Eduarda Santos de Santana,
Leila Bastos Leal,
Luzia Abílio da Silva
et al.
Abstract:Polyphenolics from Rhizophora mangle (R. mangle) have shown wound healing and antiinflammatory effects that may be potentiated by being associated with ascorbic acid, an important substance for collagen and elastin synthesis that plays a role in tissue repair. In our study, we aimed to formulate an association of R. mangle and ascorbic acid in hydrogels and evaluate the association's cytotoxic and immunomodulatory effects. In a pre-formulation study, three gelling polymers (i.e.xanthan gum, poloxamer and hydro… Show more
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