Association of Retinopathy and Glycosylated Haemoglobin Levels in Diabetes Mellitus

Re, Davis; Ij, Constable; Dj, Nicol; Vj, McCann; Ta, Welborn

doi:10.5694/j.1326-5377.1980.tb100767.x

Cited by 8 publications

(2 citation statements)

References 8 publications

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“…The results of cross-sectional studies, however, may be misleading in several ways, since the development of retinopathy often prompts a change in the attitudes of patients and physicians towards glycaemic control. 5 Nephropathy, which commonly accompanies severe retinopathy,l may raise blood pressure and cause other metabolic changes. The large prospective study of Pirart6 evaluated the contribution of factors such as glycaemic control and obesity towards the development of retinopathy, but few prospective data are available concerning other potential risk factors in insulin-dependent diabetics.…”

Section: Introductionmentioning

confidence: 99%

Factors protective against retinopathy in insulin-dependent diabetics free of retinopathy for 30 years

Dornan¹,

Mann²,

Turner³

1982

BMJ

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To investigate which factors might protect against the development of retinopathy 40 insulin-dependent diabetics who had remained free from retinopathy despite diabetes of long duration (mean±l SD 30±10 years) were compared with 40 patients who had background and 47 who had proliferative retinopathy (mean durations of disease 16+ 5 and 19 ± 5 years respectively). The three groups had had similar mean ages at onset of diabetes. The mean of all postprandial blood glucose measurements at hospital clinics from diagnosis of diabetes to detection of retinopathy, or to the most recent negative eye examination, was 9 9±2-1 mmol/l (178±38 mg/100 ml) in the group with no retinopathy, 11 8±21 mmol/l (213±38 mg/100 ml) in those with background retinopathy, and 12 4±2-1 mmol/l (223±38 mg/100 ml) in those with proliferative retinopathy (p <0 0001). This difference was not reflected in present concentrations of haemoglobin Alc, probably because glycaemic control had been improved after the development of retinopathy. In the groups with background and proliferative retinopathy there were significant negative correlations between mean blood glucose concentrations and the number of years that had elapsed from diagnosis of diabetes to detection of retinopathy, suggesting that the development of both grades of retinopathy depends on the degree and duration of glycaemic exposure.The patients with no retinopathy had attended clinic more frequently (p <0 025), more of them had required

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Section: Introductionmentioning

confidence: 99%

Factors protective against retinopathy in insulin-dependent diabetics free of retinopathy for 30 years

Dornan¹,

Mann²,

Turner³

1982

BMJ

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“…Diabetic retinopathy is predominantly a microangiopathy in which small blood vessels are affected and it is so prevalent that almost all of type 1and two third of all type2 Diabetics are expected to develop diabetic retinopathy over a period of 1-3 time . Severity of diabetic retinopathy increases over period of time and the severity is diagnosed and classified basing upon their findings (microaneurysm, exudates, retinal hemorrhages, venous beading , IRMA, new vessels in disc or 4,5 elsewhere in retina ) as per ETDRS classification . Serum glycosylated hemoglobin (HbA1c) estimates the average glycemic status over weeks to months as per the lifespan of RBCs and is a prognostic marker as well as known to be a [6][7][8] marker to access the long term control of diabetes mellitus .…”

Section: Introduction :-mentioning

confidence: 99%

A STUDY ON CLINICAL EVALUATION OF DIABETIC RETINOPATHY AND ITS CORRELATION WITH SERUM HbA1c LEVEL

Mishra

Panda²,

Nanda

et al. 2021

PIJR

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This cross-sectional clinical study titled “A clinical evaluation of diabetic retinopathy and its correlation with serum HbA1c level”was conducted in Hi-Tech medical college,Bhubaneswar from September 2019 to May 2021 by taking 67 patients from ophthalmological OPD who were diagnosed as cases of diabetic retinopathy,but not taking laser therapy and not having other non-diabetic causes of retinal degeneration and having diabetic mellitus of at least one year without considering type of diabetes or treatment taken by the patients.These 67 patients diagnosed as cases of diabetic retinopathy are classified according to their severity basing upon their findings( microaneurysm, exudates, retinal hemorrhages, venous beading , IRMA, new vessels in disc or elsewhere in retina) as per ETDRS(Abbreviated early treatment diabetic retinopathy study) classification as mild NPDR, moderate NPDR, severe NPDR, very severe NPDR, PDR. Their serum glycosylated haemoglobin (HbA1c) level of each individual in each group is detected and then mean HbA1c level of each group derived and when correlated ,we found that the mean HbA1c for mild grade of retinopathy was found to be 7.667,for moderate non-proliferative diabetic retinopathy(NPDR) 8.450,for severe NPDR 9.700,for very severe NPDR 11.447 and for Proliferative Diabetic Retinopathy(PDR) the mean HbA1c value was found to be 11.468.The P value obtained through ANOVA test for HbA1c vs. grade of diabetic retinopathy was statistically significant (Sig : 0.000).The Eta & Eta squared value for HbA1c vs grade of retinopathy was 0.695 and 0.483.So the present study reveals that more severe grades of diabetic retinopathy manifesting in patients with higher levels of HbA1c

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Diabetic Eye Diseases

Ansari

Sharma

2018

Current Practices in Ophthalmology

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Association of Retinopathy and Glycosylated Haemoglobin Levels in Diabetes Mellitus

Cited by 8 publications

References 8 publications

Factors protective against retinopathy in insulin-dependent diabetics free of retinopathy for 30 years

Factors protective against retinopathy in insulin-dependent diabetics free of retinopathy for 30 years

A STUDY ON CLINICAL EVALUATION OF DIABETIC RETINOPATHY AND ITS CORRELATION WITH SERUM HbA1c LEVEL

Diabetic Eye Diseases

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