Association of retinal nerve fibre layer thickness measured by confocal scanning laser ophthalmoscopy and optical coherence tomography with disc size and axial length

Nagai-Kusuhara, Azusa; Nakamura, Makoto; Fujioka, Miyuki; Tatsumi, Yasuko; Negi, Akira

doi:10.1136/bjo.2007.127480

Cited by 59 publications

(58 citation statements)

References 29 publications

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“…Similar to the report by Nagai-Kusuhara et al [14], the RNFL thickness decreased as AL increased (r = –0.306, p < 0.001). This was attributable either to RNFL stretching caused by axial elongation or to a genetically determined smaller number of axonal fibers.…”

Section: Discussionsupporting

confidence: 89%

Relation between Axial Length and Ocular Parameters

Park

Kim

et al. 2009

Ophthalmologica

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Purpose: To investigate the relation between axial length (AL) and ocular parameters. Methods: Measurements of ocular biometric parameters were performed with an optical biometer, pachymeter, optical coherence tomography, and an automatic refractometer. AL, refractive error (RE), central corneal thickness, anterior chamber depth (ACD), corneal curvature (CC), white-to-white distance (WWD), and retinal nerve fiber layer (RNFL) thickness were measured. AL was evaluated in relation to ocular parameters. The Pearson correlation coefficient (r) was used to statistically evaluate each scattergram. Results: With elongation of the AL, the mean RE (r = –0.790, p < 0.001), CC (r = –0.444, p < 0.001), and RNFL thickness (r = –0.306, p < 0.001) all decreased, while the mean ACD (r = 0.506, p < 0.001) and WWD (r = 0.279, p < 0.001) increased. Conclusions: In shorter eyes, there was a tendency toward hyperopia, a steeper cornea, and a thicker RNFL, and in longer eyes toward myopia, a flatter cornea, and a thinner RNFL.

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Section: Discussionsupporting

confidence: 89%

Relation between Axial Length and Ocular Parameters

Park

Kim

et al. 2009

Ophthalmologica

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“…However, the relationship between RNFL thickness and vessel density is unclear. The RNFL thickness was affected by disc size and cup rim area in a previous research [19]. To deeply understand the relationship between them, we measured the RNFL thickness and ONH structure parameters in Table 3 and analyzed their correlation by multivariable linear regression (Table 4).…”

Section: Resultsmentioning

confidence: 99%

Reliability of Vessel Density Measurements in the Peripapillary Retina and Correlation with Retinal Nerve Fiber Layer Thickness in Healthy Subjects Using Optical Coherence Tomography Angiography

She

Guo

et al. 2018

Ophthalmologica

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Purpose: To evaluate the reliability of vessel density measurements in the peripapillary retina using optical coherence tomography angiography (OCT-A) and to analyze the correlation with retinal nerve fiber layer (RNFL) thickness in healthy subjects. Method: Thirty-five healthy volunteers were recruited in the study. The optic disc region was scanned three times with spectral-domain OCT (SD-OCT) and split-spectrum amplitude decorrelation angiography by two skilled examiners. Vessel density of the peripapillary retina was automatically calculated by the software RTVue-XR (version 2015.1.1.98). The RNFL thickness on the optic nerve head was measured by SD-OCT. The coefficient of variation (CV), coefficient of repeatability, and intraclass correlation coefficients (ICC) were calculated for intraobserver repeatability. The Bland-Altman analysis was used to determine interobserver reproducibility. Correlations between peripapillary retinal vessel density and RNFL thickness were analyzed using a multivariable linear regression. Results: The mean age of the volunteers was 47.0 ± 29.7 years. The intraobserver repeatability in different sectors of the peripapillary retina was good with a high coefficient of repeatability, low CV (< 0.2%), and high ICC (0.847–0.952). The interobserver reproducibility was also good in different sectors, but should be interpreted with caution due to the difference bias caused by different observers in some quadrants. There was a significant positive correlation between vessel density and RNFL thickness; optic disc rim area and disc area were negatively related to vessel density (p = 0.008 and p = 0.001, respectively). Conclusion: Vessel density measurements showed good repeatability and reproducibility by OCT-A in the peripapillary retina, the vessel density was positively related to RNFL thickness and negatively related to optic disc area and rim area.

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“…The OCT measurements of RNFL thickness have been previously described as dependent on race, age, axial length, and disc area in adult eyes, 25,32 with a reported average RNFL thickness decrease of 2.2 µm for every 1-mm increase in axial length, and an average RNFL thickness decrease of 2 µm for every decade of aging. …”

Section: Commentmentioning

confidence: 99%

Optical Coherence Tomography in the Eyes of Normal Children

El-Dairi¹

2009

Arch Ophthalmol

179

106

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To collect a normative database of macular thickness, retinal nerve fiber layer (RNFL) thicknesses, and optic nerve topography in the healthy eyes of children aged 3 to 17 years using optical coherence tomography (OCT) measurements.Methods: Scans were obtained for 286 healthy children (black, 114; white, 154; other, 18). Each child had a dilated eye examination, an axial length measurement using the IOL Master (Carl Zeiss Meditec, Dublin, California), and OCT measurements using the fast macular map, fast RNFL thickness, and fast optic disc protocols of the Stratus OCT (OCT-3; Carl Zeiss Meditec).Results: Black children had smaller macular volume and foveal thickness, larger RNFL thickness, and larger cup-

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Association of retinal nerve fibre layer thickness measured by confocal scanning laser ophthalmoscopy and optical coherence tomography with disc size and axial length

Cited by 59 publications

References 29 publications

Relation between Axial Length and Ocular Parameters

Relation between Axial Length and Ocular Parameters

Reliability of Vessel Density Measurements in the Peripapillary Retina and Correlation with Retinal Nerve Fiber Layer Thickness in Healthy Subjects Using Optical Coherence Tomography Angiography

Optical Coherence Tomography in the Eyes of Normal Children

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