Association of residual feed intake with intestinal microbiome and metabolome in laying period of ducks

Sun, Hanxue; Xu, Wenwu; Gu, Tiantian; Jing, Sun; Li, Chengfeng; Chen, Li; Tian, Yong; Li, Guoqin; Liu, Lizhi; Zeng, Tao

doi:10.3389/fmicb.2023.1138914

Cited by 2 publications

(1 citation statement)

References 58 publications

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“…The quality of eggs plays a crucial role for both producers and consumers during storage, processing, and consumption processes. Consistent with the findings of Sun [39] , our study also found no significant differences between the high and low RFI groups in terms of ESI, ESC, and EW. Therefore, selective breeding for RFI during the late stage of egg production is possible, as it can reduce feed consumption without significantly affecting egg quality.…”

Section: Discussionsupporting

confidence: 92%

In-depth investigation of the mechanisms of high and low residual feed intake regulating hens during the late laying period via liver and gut microbiota

Gao,

Zheng,

Mao

et al. 2024

Preprint

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The RFI is independent of growth traits and selecting individuals with low RFI can improve feed efficiency without affecting the laying performance and egg quality of hens. In this study it was found that under similar egg production rates hens in the HRFI group had lower nutrient digestion capacity disrupted lipid metabolism and lower feed utilization efficiency than those in the LRFI group. Further research and validation are needed to investigate the effects of AST HDL-C and ACTH on feed efficiency in the late laying period through serum biochemical index analysis. Through multiomics analysis genes such as ADCY2 ADCY8 CCKAR ACSS2 FABP1 and FABP4 and metabolites such as LysoPI(18:2(9Z,12Z)/0:0) were identified as key genes and biomarkers related to RFI in laying hens during the late laying period. These findings are important for developing strategies to improve feed efficiency in Rhode Island Red pure-line chickens during the late laying period. Additionally in-depth investigations such as histological observations enzyme activity analysis and integration of multiomics techniques are needed to unravel the physiological and biochemical mechanisms of digestive organs that impact feed utilization efficiency in poultry.

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Section: Discussionsupporting

confidence: 92%

In-depth investigation of the mechanisms of high and low residual feed intake regulating hens during the late laying period via liver and gut microbiota

Gao,

Zheng,

Mao

et al. 2024

Preprint

View full text Add to dashboard Cite

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Dietary silymarin improves performance by altering hepatic lipid metabolism and cecal microbiota function and its metabolites in late laying hens

Guo,

Xu,

Wang

et al. 2024

J Animal Sci Biotechnol

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Background Liver lipid dysregulation is one of the major factors in the decline of production performance in late-stage laying hens. Silymarin (SIL), a natural flavonolignan extracted from milk thistle, is known for its hepatoprotective and lipid-lowering properties in humans. This study evaluates whether SIL can provide similar benefits to late-stage laying hens. A total of 480 68-week-old Lohmann Pink laying hens were randomly assigned into 5 groups, each group consisting of 6 replicates with 16 hens each. The birds received a basal diet either without silymarin (control) or supplemented with silymarin at concentrations of 250, 500, 750, or 1,000 mg/kg (SIL250, SIL500, SIL750, SIL1000) over a 12-week period. Results The CON group exhibited a significant decline in laying rates from weeks 9 to 12 compared to the initial 4 weeks (P = 0.042), while SIL supplementation maintained consistent laying rates throughout the study (P > 0.05). Notably, the SIL500 and SIL750 groups showed higher average egg weight than the CON group during weeks 5 to 8 (P = 0.049). The SIL750 group had a significantly higher average daily feed intake across the study period (P < 0.05), and the SIL500 group saw a marked decrease in the feed-to-egg ratio from weeks 5 to 8 (P = 0.003). Furthermore, the SIL500 group demonstrated significant reductions in serum ALT and AST levels (P < 0.05) and a significant decrease in serum triglycerides and total cholesterol at week 12 with increasing doses of SIL (P < 0.05). SIL also positively influenced liver enzyme expression (FASN, ACC, Apo-VLDL II, FXR, and CYP7A1; P < 0.05) and altered the cecal microbiota composition, enhancing species linked to secondary bile acid synthesis. Targeted metabolomics identified 9 metabolites predominantly involved in thiamin metabolism that were significantly different in the SIL groups (P < 0.05). Conclusions Our study demonstrated that dietary SIL supplementation could ameliorate egg production rate in late stage laying hens, mechanistically, this effect was via improving hepatic lipid metabolism and cecal microbiota function to achieve. Revealed the potentially of SIL as a feed supplementation to regulate hepatic lipid metabolism dysregulation. Overall, dietary 500 mg/kg SIL had the best effects. Graphical Abstract

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Association of residual feed intake with intestinal microbiome and metabolome in laying period of ducks

Cited by 2 publications

References 58 publications

In-depth investigation of the mechanisms of high and low residual feed intake regulating hens during the late laying period via liver and gut microbiota

In-depth investigation of the mechanisms of high and low residual feed intake regulating hens during the late laying period via liver and gut microbiota

Dietary silymarin improves performance by altering hepatic lipid metabolism and cecal microbiota function and its metabolites in late laying hens

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