Association of regulator of G protein signaling (RGS5) gene variants and essential hypertension in Mongolian and Han populations

Py, Chang; Qin, Liang; Zhao, Ping; Zy, Liu

doi:10.4238/2015.december.21.37

Cited by 6 publications

(4 citation statements)

References 24 publications

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“…RGS5 is a family member that is highly expressed in vSMCs and plays a pivotal role in vascular pathologies (Box 3). RGS5 is a negative modulator of AngII/ATR1 signaling in vitro and in humans RGS5 gene polymorphism has been associated with hypertension in the general population [60][61][62] 22 (Table 1) protecting from atherosclerotic plaque formation has been demonstrated in RGS5 gene deficient mice [73]. Similar to PPARs, RGS5 appears to protect from sequelae of the metabolic syndrome such as diet-induced obesity, hepatic steatosis, inflammation, and insulin resistance [76].…”

Section: Rgs5 and Pregnancy-associated Hypertensionmentioning

confidence: 99%

Maternal Metabolism and Vascular Adaptation in Pregnancy: The PPAR Link

Ganss

2017

Trends in Endocrinology & Metabolism

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Current therapies for pregnancy-related hypertension and its complications remain inadequate, although an increasing role for maternal susceptibility is becoming evident. Systemic vascular dysfunction in response to imbalances in angiogenic, inflammatory, and constricting factors is implicated in the pathogenesis of gestational hypertension, and growing evidence now links these factors with maternal metabolism. In particular, the crucial role of peroxisome proliferator-activated receptors (PPARs) in maternal vascular adaptation provides further insights into how obesity and gestational diabetes may be linked to pregnancy-induced hypertension and preeclampsia. This is especially important given the rapidly growing prevalence of obesity during pregnancy, and highlights a new approach to treat pregnancy-related hypertension and its complications.

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Section: Rgs5 and Pregnancy-associated Hypertensionmentioning

confidence: 99%

Maternal Metabolism and Vascular Adaptation in Pregnancy: The PPAR Link

Ganss

2017

Trends in Endocrinology & Metabolism

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“…A study demonstrated that RGS5 may be a candidate target gene for the treatment of human and animal www.nature.com/scientificreports www.nature.com/scientificreports/ hypertension. Indeed, RGS5 genetic polymorphisms have been shown to be associated with human hypertension 39 . Additionally, the expression level of RGS5 in the vascular smooth muscle and intima was markedly reduced in spontaneously hypertensive rats and adrenocorticotropic hormone-and Ang-II-induced hypertensive rats, while the blood pressure level was increased in RGS5-knockout mice 37,40,41 .…”

Section: Discussionmentioning

confidence: 99%

Human cytomegalovirus promoting endothelial cell proliferation by targeting regulator of G-protein signaling 5 hypermethylation and downregulation

Zhang

Tang

et al. 2020

Sci Rep

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interactions between human cytomegalovirus (HcMV) infection and environmental factors can increase susceptibility to essential hypertension (eH). Although endothelial dysfunction is the initial factor of EH, the epigenetic mechanisms through which HCMV infection induces endothelial cell dysfunction are poorly understood. Here, we evaluated whether HCMV regulated endothelial cell function and assessed the underlying mechanisms. Microarray analysis in human umbilical vein endothelial cells (HUVecs) treated with HCMV AD169 strain in the presence of hyperglycemia and hyperlipidemia revealed differential expression of genes involved in hypertension. Further analyses validated that the regulator of G-protein signaling 5 (RGS5) gene was downregulated in infected HUVecs and showed that HcMV infection promoted HUVEC proliferation, whereas hyperglycemia and hyperlipidemia inhibited HUVEC proliferation. Additionally, treatment with decitabine (DAC) and RGS5 reversed the effects of HCMV infection on HUVEC proliferation, but not triggered by hyperglycemia and hyperlipidemia. In summary, upregulation of RGS5 may be a promising treatment for preventing HCMV-induced hypertension.Essential hypertension (EH) is a major risk factor of cardiovascular disease, involving endothelial dysfunction of large and small resistance arteries 1 . According to a previously performed study, EH is estimated to affect approximately 1.56 billion adults by 2025 2 . Despite this, the underlying cause and pathological mechanisms of EH have remained elusive. A number of previous studies revealed that hypertension is associated not only with genetic and environmental factors, but also with human cytomegalovirus (HCMV) infection, DNA methylation, and other epigenetic mechanisms 3 .As reported previously, HCMV, which belongs to the β-herpes virus family, causes persistent infection in human 4,5 . HCMV accounts for 50-90% of the adult cases as a common opportunistic pathogen 6 . There is a growing evidence that cytomegalovirus infection may be associated with hypertension 7-10 . According to our previous researches, HCMV infection is related to essential hypertension in Kazakh men and Hans in Xinjiang, China, and HCMV antibody titers are associated with blood pressure and hypertension in Han men and women 11 . Studies demonstrated that HCMV can infect endothelial cells (ECs), macrophages and smooth muscle cells, which are all of great importance in the pathogenesis of vascular diseases 12,13 . HCMV infection is related to the pathogenesis of EH since it elicits vascular cells (e.g., ECs) dysfunction. In addition, mechanisms, such as dysfunction of ECs, inflammatory responses, CMV-specific T-cell responses to oxidative stress, and RAS activity indicate that HCMV infection is associated with EH.Endothelial dysfunction is an early event in the pathophysiology of EH 14 . ECs are in vivo targets of HCMV infection and play a pivotal role in viral pathogenesis [15][16][17] . Besides, ECs are the first site of HCMV infection, which are a potential virus reservoir f...

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“…A total of 40 ligase detection reaction cycles were performed under conditions of 92°C for 2 min, 94°C for 15 s, and 50°C for 25 s. The fluorescent products of ligase detection reaction were identified by PRISM 3730 (ABI). The experimental methods are similar to Chang et al [15].…”

Section: Methodsmentioning

confidence: 99%

Variants in the 3′ End of SLC6A3 in Northwest Han Population with Parkinson’s

Chang

Zhao

et al. 2019

Parkinson's Disease

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Parkinson’s disease (PD) is one of the most common neurodegenerative disorders in neurology. It is possible that multifactorial and genetic factors are related to its pathogenesis. Recently, there have been reports of SLC6A3 genetic variants leading to PD. However, the role of 3′ end of SLC6A3 in PD is less studied in different ethnic groups. To explore the roles of 3′ end of SLC6A3 in PD development, 17 SNP sites in 3′ end of SLC6A3 were analyzed in 360 PD patients and 392 normal controls of Han population residing in northwest of China. The significant difference of gene type and allele frequencies between the PD and control groups was detected only in rs40184 (P = 0.013 and 0.004, respectively; odds ratio 2.529, 95% confidence interval 1.325–4.827). The genotype and allele frequencies of the other 16 SNP sites were not found to be different between the PD group and the control group. rs2550936, rs3776510, and rs429699 were selected to construct the haplotypes; no significant difference was found in a frequency of 5 haplotypes between the PD group and the control group. These results suggest that the SLC6A3 variant in rs40184 A allele may increase the risk of PD in northwest Han population and may be a biomarker of PD.

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Association of regulator of G protein signaling (RGS5) gene variants and essential hypertension in Mongolian and Han populations

Cited by 6 publications

References 24 publications

Maternal Metabolism and Vascular Adaptation in Pregnancy: The PPAR Link

Maternal Metabolism and Vascular Adaptation in Pregnancy: The PPAR Link

Human cytomegalovirus promoting endothelial cell proliferation by targeting regulator of G-protein signaling 5 hypermethylation and downregulation

Variants in the 3′ End of SLC6A3 in Northwest Han Population with Parkinson’s

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