Association of reduced retinal arteriolar tortuosity with depression in older participants from the Northern Ireland Cohort for the Longitudinal Study of Ageing

O'Neill, R A; Maxwell, Alexander P.; Kee, Frank; Hogg, Ruth; Cruise, Sharon; McKay, Gareth J.

doi:10.1186/s12877-021-02009-z

Cited by 6 publications

(3 citation statements)

References 50 publications

(67 reference statements)

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“…In individuals with T2DM and depression, wider arteriolar width in the retina has been observed [ 125 ]. Table 1 highlights associations between a wider retinal venular or arteriolar calibre, reduced arterial tortuosity, and higher plasma markers of endothelial dysfunction with an increased prevalence or incidence of depression [ 122 , 126 , 127 , 128 , 129 ]. However, inconsistencies in reporting this association exist, potentially attributable to selection bias, variations in retinal microvascular changes, and differences in measurement time points [ 130 , 131 ].…”

Section: Depression and Retinal Microvascular Changesmentioning

confidence: 99%

Depression and Eye Disease—A Narrative Review of Common Underlying Pathophysiological Mechanisms and their Potential Applications

Tang,

Lau,

Krishnan

et al. 2024

JCM

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Background: Depression has been shown to be associated with eye diseases, including dry eye disease (DED), cataracts, glaucoma, age-related macular degeneration (AMD), and diabetic retinopathy (DR). This narrative review explores potential pathophysiological connections between depression and eye disease, as well as its potential correlations with ocular parameters. Methods: A literature search was conducted in August 2022 in PUBMED, EMBASE, and PsycINFO. Published articles related to the subject were consolidated and classified according to respective eye diseases and pathophysiological mechanisms. Results: The literature reviewed suggests that common pathophysiological states like inflammation and neurodegeneration may contribute to both depression and certain eye diseases, while somatic symptoms and altered physiology, such as disruptions in circadian rhythm due to eye diseases, can also influence patients’ mood states. Grounded in the shared embryological, anatomical, and physiological features between the eye and the brain, depression is also correlated to changes observed in non-invasive ophthalmological imaging modalities, such as changes in the retinal nerve fibre layer and retinal microvasculature. Conclusions: There is substantial evidence of a close association between depression and eye diseases. Understanding the underlying concepts can inform further research on treatment options and monitoring of depression based on ocular parameters.

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Section: Depression and Retinal Microvascular Changesmentioning

confidence: 99%

Depression and Eye Disease—A Narrative Review of Common Underlying Pathophysiological Mechanisms and their Potential Applications

Tang,

Lau,

Krishnan

et al. 2024

JCM

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“…Building on research showing that psychosocial stress in childhood was associated with cardiovascular dysfunction, some studies have investigated the effects of psychosocial stress on the retinal microvasculature. Altered retinal microvasculature has been associated with depression and anxiety in adolescents and adults (56)(57)(58)(59)(60)(61), lower quality of life (62), and vital exhaustion (63). However, some studies have found either a weak association or no association between psychosocial stress and retinal microvasculature (64,65).…”

Section: The Retina As a Model Of Brain Healthmentioning

confidence: 99%

Childhood Social Isolation as a Predictor of Retinal Neuronal Thickness in Middle Age: A Lifecourse Birth Cohort Study

et al. 2023

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Objective: We investigated whether childhood social isolation was associated with retinal neural layer changes in adulthood, and whether this association was independent of other childhood or adulthood risk factors, including adult social isolation. Methods: Participants were members of the Dunedin Multidisciplinary Health and Development Study, a longitudinal population-based birth cohort from Aotearoa New Zealand (n = 1037), born 1972 to 1973 and followed until age 45 years, with 94% of the living cohort still participating. Social isolation was recorded prospectively at ages 5, 7, 9, and 11 years, from teacher and parent report. Retinal nerve fiber layer (RNFL) and ganglion cell-inner plexiform layer thicknesses were measured via optical coherence tomography at age 45 years. Results: Childhood social isolation was associated with thinner average RNFL (B = −0.739, p = .02), nasal RNFL (B = −1.118, p = .005), and inferior RNFL (B = −1.524, p = .007), although only nasal RNFL remained significant after adjustment. These associations were not fully explained by other psychosocial or physical health risk factors in childhood or adulthood, nor were they mediated by adult loneliness or social support. Conclusions: Childhood social isolation was an independent predictor of RNFL thickness in middle age. Highlighting prospective links between childhood psychosocial adversity and retinal neuronal measures will help to inform future research into the utility of retinal neuronal thickness as a biomarker for neurodegeneration.

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“…So depression in the elderly is a chronic disease that needs urgent attention. 4 Depression is a intricate public health problem with the characteristics of large differences in response to treatment.The systemic complexity of depression, or the feedback process between the different drivers of the disorder, leads to the persistence of depression. 5 According to reports, systemic chronic low-grade inflammation is related to the progression of Major depressive disorder (MDD) by affecting monoaminergic and glutamatergic neurotransmission.However, whether various proinflammatory cytokines are abnormally elevated before the first onset of depression remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Investigating Associations Between Depressive Symptoms and Anti-/Pro-Inflammatory Nutrients in an Elderly Population in Northern China: A Bayesian Kernel Machine Regression Approach

Li¹,

Zhan²,

Huang³

et al. 2021

JIR

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Backgroud:The potential for dietary inflammation has been shown to be associated with a variety of chronic diseases. The relationship between the potential for dietary inflammation and depression in the elderly is unclear.Objective: This study aimed to exam the relationship between different nutrients and the risk of depression symptoms in the elderly. Methods: In total, 1865 elderly in northern China were investigated at baseline from 2018 to 2019 and followed up in 2020. We measured the baseline intake of 22 nutrients and used Least Absolute Shrinkage and Selection Operator(LASSO) regression analysis and Bayesian Kernel Machine Regression (BKMR) to explore the association between exposure to a variety of nutrients with different inflammatory potentials and the risk of depressive symptoms. Results: A total of 447 individuals (24.0%) were diagnosed with depressive symptoms. Through the lasso regression model, it was found that 11 nutrients are significantly related to the risk of depressive symptoms, of which 6 nutrients are pro-inflammatory nutrients (inflammation effect score>0), and 5 are anti-inflammatory nutrients (inflammation effect score<0). We incorporated the inflammatory effect scores of 11 nutrients into the BKMR model at the same time, and found that the overall inflammatory effect of 11 nutrients increased with the increase of total inflammatory scores, suggesting that the overall effect was pro-inflammatory. BKMR subgroup analysis shows that whether in the proinflammatory nutrient group or the anti-inflammatory nutrient group, multiple nutrients have a significant combined effect on depressive symptoms. By comparing the overall and group effects, we found that the inflammatory effects of the pro-inflammatory diet and the anti-inflammatory diet in the study's diet are offset by each other (P<0.005). Conclusion:We determined the combined effect of multiple nutrients of different inflammatory potential classifications on depressive symptoms in the elderly.

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Association of reduced retinal arteriolar tortuosity with depression in older participants from the Northern Ireland Cohort for the Longitudinal Study of Ageing

Cited by 6 publications

References 50 publications

Depression and Eye Disease—A Narrative Review of Common Underlying Pathophysiological Mechanisms and their Potential Applications

Depression and Eye Disease—A Narrative Review of Common Underlying Pathophysiological Mechanisms and their Potential Applications

Childhood Social Isolation as a Predictor of Retinal Neuronal Thickness in Middle Age: A Lifecourse Birth Cohort Study

Investigating Associations Between Depressive Symptoms and Anti-/Pro-Inflammatory Nutrients in an Elderly Population in Northern China: A Bayesian Kernel Machine Regression Approach

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