Association of red blood cell distribution width with severity of hepatitis B virus-related liver diseases

Fan, Xiude; Deng, Huan; Wang, Xiqiang; Fu, Shiqi; Zitong, Liu; Sang, Jiao; Zhang, Xiaoge; Li, Na; Han, Qunying; Liu, Zhengwen

doi:10.1016/j.cca.2018.04.002

Cited by 35 publications

(23 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this context, RDW is a hematological parameter that reflects heterogeneity in red blood cell size, [5,6] and is reportedly associated with systemic inflammation. [7,8] Given the readily available nature of RDW, it may be more clinically useful than other markers. Furthermore, RDW has been used to distinguish iron deficiency anemia from thalassemia or other hemoglobinopathies, and recent studies have identified elevated RDW in cases of atherosclerosis, inflammatory diseases, and cancers, [22,23] which highlights the potential utility of RDW in CRC diagnosis and prognostication.…”

Section: Discussionmentioning

confidence: 99%

“…[5,6] Elevated RDW values are associated with several types of anemias, as well as with certain liver disorders and systemic inflammation. [7,8] Recent studies have also indicated that RDW is associated with the development of several cancers, with potential diagnostic and prognostic value for esophageal cancer, multiple myeloma, and hepatocellular carcinoma. [9–11] However, there are scarce and inconsistent data regarding the diagnostic value of RDW in CRC.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The association and diagnostic value of red blood cell distribution width in colorectal cancer

Shi

Xie

et al. 2019

Medicine

View full text Add to dashboard Cite

Red blood cell distribution width (RDW) is associated with several diseases. However, the diagnostic value of RDW and its related factors remain unclear in colorectal cancer (CRC). This single-center retrospective study evaluated 211 Chinese CRC patients and 103 healthy controls. The association of RDW with the clinical parameters of CRC, as well as its correlations with carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) were analyzed. The diagnostic value of RDW alone or combined with CEA and CA19-9 was evaluated using receiver operating characteristic curve analysis. A meta-analysis was also performed to combine our data with previously published data to enhance our findings. In the CRC patients, RDW was clearly elevated and was significantly associated with CRC tumor location, histological type, T status (but not N or M status), and clinical stage. However, RDW was not significantly correlated with CEA or CA19-9 levels. Using RDW to diagnose CRC provided a sensitivity of 53.1% and specificity of 77.7%. The diagnostic accuracy of RDW was enhanced by combining RDW with CEA and CA19-9 levels. We identified 5 previous studies with 633 CRC patients and 1050 controls, which were combined with our cases and controls. The meta-analysis revealed an overall sensitivity of 69%, specificity of 70%, and an area under the curve of 0.74. In CRC cases, RDW was associated with tumor location, histological type, T status, and clinical stage. Furthermore, RDW had a moderate value for diagnosing CRC and might be useful in this setting.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The association and diagnostic value of red blood cell distribution width in colorectal cancer

Shi

Xie

et al. 2019

Medicine

View full text Add to dashboard Cite

show abstract

“…Therefore, a comprehensive model composed of parameters derived from peripheral CBC with differential has potential to predict MP-related hepatitis. Among the MRP model, RDW has been identi ed as a biomarker in monitoring disease course and predicting the severity of hepatitis, such as autoimmune hepatitis 12 , hepatitis B-related hepatitis [13][14][24][25][26] and nonalcoholic steatohepatitis 27 . RDW levels are usually elevated with progressive liver in ammation.…”

Section: Discussionmentioning

confidence: 99%

Risk of Mycoplasma Pneumoniae-Related Hepatitis in MP Pneumonia Pediatric Patients: A Predictive Model Construction and Assessment

Zhuo

et al. 2020

Preprint

View full text Add to dashboard Cite

BackgroundA predictive model for risk of Mycoplasma pneumoniae (MP)-related hepatitis in MP pneumonia pediatric patients can improve treatment selection and therapeutic effect. However, currently, no predictive model is available. Methods374 pneumoniae pediatric patients with/without serologically-confirmed MP infection and 93 health controls were enrolled. Logistic regressions were performed to identify the determinant variables and develop predictive model. Predictive performance and optimal diagnostic threshold were evaluated using area under the receiver operating characteristic curve (AUROC). Stratification analysis by age and MP-IgM titer was used to optimize model’s clinical utility. An external validation set, including 84 MP pneumoniae pediatric patients, was used to verify the predictive efficiency. After univariate analysis to screen significant variables, monocyte count (MO), erythrocyte distribution width (RDW) and platelet count (PLT) were identified as independent predictors in multivariate analysis. ResultsWe constructed MRP model: MO[^109/L]×4+RDW[%]-PLT[^109/L]×0.01. MRP achieved an AUROC of 0.754 and the sensitivity and specificity at cut-off value 10.44 were 71.72% and 61.00%, respectively in predicting MP-related hepatitis from MP pneumonia. These results were verified by the external validation set, whereas it merely achieved an AUROC of 0.540 in pneumonia without MP infection. The AUROC of MRP was 0.812 and 0.787 in infants and toddlers (0-36 months) and low MP-IgM titer subgroup (1:160-1:320), respectively. It can achieve an AUROC of 0.804 in infants and toddler with low MP-IgM titer subgroup. ConclusionsMRP is an effective predictive model for risk of MP-related hepatitis in MP pneumonia pediatric patients, especially infants and toddlers with low MP-IgMtiter.

show abstract

“…Concerning about the significance of RDW in HBV-related diseases, some researches had been reported 19-24. RDW values were reported to be significantly increased in patients with hepatitis B and were associated with its severity 19-20.…”

Section: Introductionmentioning

confidence: 99%

“…However, few researches concern about the dynamic differences of RDW levels during HBV-related chronic liver diseases and the knowledge of clinical significance of RDW is also limited. Fan X and his colleagues reported that RDW among CHB patients was elevated compared with healthy controls, based on meta-analysis 24.…”

Section: Introductionmentioning

confidence: 99%

Dynamic Differences Of Red Cell Distribution Width Levels Contribute To The Differential Diagnosis Of Hepatitis B Virus-related Chronic Liver Diseases: A Case-control Study

Zhu¹,

Han²,

Xiao³

et al. 2019

Int. J. Med. Sci.

View full text Add to dashboard Cite

Objective: This study aims to clarify the changes and clinical significance of red cell distribution width (RDW) during HBV-related chronic diseases, including inactive hepatitis B virus (HBV) carriers, HBV immune tolerant individuals, chronic hepatitis B (CHB) patients and HBV-related hepatocirrhosis patients. Methods: RDW was measured 288 CHB patients, 100 patients with hepatitis B e antigen(HBeAg)-negative chronic HBV infection (inactive carriers), 92 patients with HBeAg-positive chronic HBV infection (immune tolerant), and 272 patients with HBV-related hepatocirrhosis. Their RDW changes were compared with 160 healthy controls. Correlations between RDW and clinical indicators were conducted. For HBeAg+ CHB patients, RDW was measured before and after antiviral therapy. The efficiency of RDW to distinguish hepatocirrhosis from CHB and/or inactive carriers was evaluated by receiver operating characteristic (ROC) curves. Results : RDW was higher in hepatocirrhosis patients than other groups of patients and healthy controls. Besides, HBeAg+ CHB patients possessed higher RDW than HBeAg- CHB patients. For HBeAg+ patients that underwent HBeAg seroconversion after antiviral therapy, RDW was decreased. RDW was positively correlated with total bilirubin and Child-Pugh scores and negatively correlated with albumin among hepatocirrhosis patients. The areas under the curve (AUC) of ROC curves to distinguish hepatocirrhosis from CHB patients was 0.7040 for RDW-standard deviation (RDW-SD) and 0.6650 for RDW-coefficient of variation (RDW-CV), and AUC to distinguish hepatocirrhosis from inactive carriers was 0.7805 for RDW-SD and 0.7991 for RDW-CV. Conclusions : RDW is significantly increased in HBeAg+ CHB patients and patients with HBV-related hepatocirrhosis and could reflect their severity. RDW could help to distinguish hepatocirrhosis from CHB patients and inactive HBV carriers.

show abstract

Association of red blood cell distribution width with severity of hepatitis B virus-related liver diseases

Cited by 35 publications

References 31 publications

The association and diagnostic value of red blood cell distribution width in colorectal cancer

The association and diagnostic value of red blood cell distribution width in colorectal cancer

Risk of Mycoplasma Pneumoniae-Related Hepatitis in MP Pneumonia Pediatric Patients: A Predictive Model Construction and Assessment

Dynamic Differences Of Red Cell Distribution Width Levels Contribute To The Differential Diagnosis Of Hepatitis B Virus-related Chronic Liver Diseases: A Case-control Study

Contact Info

Product

Resources

About