Search citation statements
Paper Sections
Citation Types
Year Published
Publication Types
Relationship
Authors
Journals
Aim To determine the predictive significance of the platelet-to-lymphocyte ratio (PLR) combined with the CHA 2 DS 2 -VAS c score for cardiogenic cerebral embolism (CCE) in patients with nonvalvular atrial fibrillation (NVAF). Methods A total of 553 patients with NVAF were included in this retrospective study. The general data, PLR, CHA 2 DS 2 -VAS c score and echocardiography indicators were compared. The risk factors for CCE and the predictive value of PLR and CHA 2 DS 2 -VAS c were analyzed. Stratified analysis was performed based on the cut-off value. Least absolute shrinkage and selection operator (LASSO) regression analysis was utilized to build a model. The relationship between risk score and different anticoagulants was evaluated. Results Multiple regression analysis showed hypertension (OR=3.95, 95% CI=2.12–7.35, p =1.40×10 −5 ), diabetes mellitus (OR=2.95, 95% CI=1.57–5.58, p =7.65×10 −4 ), PLR (OR=1.01, 95% CI=1.00–1.01, p <10 −6 ), creatinine level (OR=1.01, 95% CI=1.00–1.02, p =7.44×10 −3 ), left atrial diameter (LAD) (OR=1.90, 95% CI=1.13–3.19, p =1.51×10 −2 ), ejection fraction (EF) (OR=0.93, 95% CI=0.87–0.98, p =8.06×10 −3 ) and CHA 2 DS 2 -VAS c score (OR=3.79, 95% CI=2.95–4.85, p <10 −6 ) were independent risk factors for CCE. A one-way linear analysis also showed the above seven indexes were significantly correlated with CCE ( F =56.4, p <10 −6 ). The area under the receiver operating characteristic (ROC) curve of PLR and CHA 2 DS 2 -VAS c score was 0.760 (95% CI:0.721–0.800), and 0.855 (95% CI: 0.824–0.886), respectively. Pearson correlation analysis showed that PLR was correlated with CHA 2 DS 2 -VAS c score (r=0.331, p <10 −6 ). Stratified analysis indicated there was a positive correlation between different risk group ( p <10 −6 ). Using the LASSO model, a composite indicator displayed differential power for distinguishing CCE with an AUC value of 0.884 (95% CI: 0.857–0.911). Patient...
Aim To determine the predictive significance of the platelet-to-lymphocyte ratio (PLR) combined with the CHA 2 DS 2 -VAS c score for cardiogenic cerebral embolism (CCE) in patients with nonvalvular atrial fibrillation (NVAF). Methods A total of 553 patients with NVAF were included in this retrospective study. The general data, PLR, CHA 2 DS 2 -VAS c score and echocardiography indicators were compared. The risk factors for CCE and the predictive value of PLR and CHA 2 DS 2 -VAS c were analyzed. Stratified analysis was performed based on the cut-off value. Least absolute shrinkage and selection operator (LASSO) regression analysis was utilized to build a model. The relationship between risk score and different anticoagulants was evaluated. Results Multiple regression analysis showed hypertension (OR=3.95, 95% CI=2.12–7.35, p =1.40×10 −5 ), diabetes mellitus (OR=2.95, 95% CI=1.57–5.58, p =7.65×10 −4 ), PLR (OR=1.01, 95% CI=1.00–1.01, p <10 −6 ), creatinine level (OR=1.01, 95% CI=1.00–1.02, p =7.44×10 −3 ), left atrial diameter (LAD) (OR=1.90, 95% CI=1.13–3.19, p =1.51×10 −2 ), ejection fraction (EF) (OR=0.93, 95% CI=0.87–0.98, p =8.06×10 −3 ) and CHA 2 DS 2 -VAS c score (OR=3.79, 95% CI=2.95–4.85, p <10 −6 ) were independent risk factors for CCE. A one-way linear analysis also showed the above seven indexes were significantly correlated with CCE ( F =56.4, p <10 −6 ). The area under the receiver operating characteristic (ROC) curve of PLR and CHA 2 DS 2 -VAS c score was 0.760 (95% CI:0.721–0.800), and 0.855 (95% CI: 0.824–0.886), respectively. Pearson correlation analysis showed that PLR was correlated with CHA 2 DS 2 -VAS c score (r=0.331, p <10 −6 ). Stratified analysis indicated there was a positive correlation between different risk group ( p <10 −6 ). Using the LASSO model, a composite indicator displayed differential power for distinguishing CCE with an AUC value of 0.884 (95% CI: 0.857–0.911). Patient...
Background/Aim: Increased frailty with age along with an increase in comorbidities heighten mortality in intensive care units. According to the World Health Organization, old age is divided into three stages: 65–74 years, 75–84 years, and 85 years and older. The lengthened human lifespan leads to a growth in the number of elderly patients in intensive care units, and the need to know the factors associated with prognosis in the three stages of old age. We aimed to define factors affecting mortality in these three stages of aging and the factors that can help predict prognoses. Methods: In this retrospective cohort, data of patients over the age of 65 who were admitted to the intensive care unit of Bolu Izzet Baysal State Hospital between January 2016 and December 2020 were recorded using the hospital's automation system. Demographic data, blood tests, diagnoses and inflammatory biomarkers, such as RDW, NLR, and CAR were recorded. The data were analyzed using SPSS, and P<0.05 was considered significant. Results: In this study, 46.2% of the 1566 patients died. The most common diagnosis for admission to the intensive care unit was sepsis, and the most common comorbidity was hypertension. While neurological impairment (P<0.001), malignancy (P=0.006), and cardiac disease (P=0.004) were associated with mortality in all three stages of old age, chronic obstructive pulmonary disease was associated with mortality in the 85 years and older age group (P=0.011) and diabetes in those aged 65–74 years and 75–84 years. The APACHE II score (P<0.001) and red cell distribution width (P<0.001) were highly effective in predicting prognoses in all three stages of old age. Conclusion: In examining the factors associated with mortality in older age intensive care unit patients, we found that the APACHE II score and red cell distribution width were effective in establishing prognoses for all age groups.
Background: Red blood cell distribution width (RDW) is being actively studied as a biomarker in various cardiovascular diseases (CVDs). The aim of this study was to conduct a comparative analysis of RDW in patients with carotid atherosclerosis, comparing it with an assessment of the severity of carotid artery stenosis (CAS). Methods: The Duplex registry database was used to conduct this retrospective cross-sectional study. The study participants underwent a complete blood count test, analysis for lipid profile, and carotid ultrasound. The patients were divided into 5 groups depending on CAS degree: none; 20%–49%; 50%–69%; 70%–99%; and occlusion. Results: Data from 2548 patients were included in the final analysis (mean age: 57.9 ± 12.3 years; 51% males [n = 1301]). The analysis confirmed the relationship between the increase in the RDW index and CAS gradation increase in men (Kr-W H = 16.43; P = 0.0009), but was not confirmed in women (Kr-W H = 4.32; P = 0.22). Significantly higher levels of high-density lipoprotein cholesterol and platelets and lower levels of red blood cell and white blood cells were registered in female patients without CAS and with CAS < 50% compared with men (P < 0.001). Conclusion: The results of the present study showed that RDW is an indicator whose increase is associated with an increase in the degree of carotid atherosclerosis in men, but not in women. This allows to discuss the role of the RDW index as a possible new laboratory biomarker of inflammation and progression of atherosclerosis, which can make an additional contribution to the formation of increased morbidity and mortality in men from atherosclerotic CVD.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.