2017
DOI: 10.1136/openhrt-2017-000683
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Association of QT interval with mortality by kidney function: results from the National Health and Nutrition Examination Survey (NHANES)

Abstract: ObjectiveProlonged QT interval predisposes to ventricular arrhythmias and sudden cardiac death. However, the association between QT interval and mortality by the level of pre-existing kidney function has not been investigated.MethodsWe followed 6565 participants from the National Health and Nutrition Examination Survey III for a median of 13.3 years. Sample divided according to corrected QT (QTc) interval was as follows: normal (QTc <450 ms for men and <460 ms for women) or prolonged. It was further categorise… Show more

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Cited by 14 publications
(19 citation statements)
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“…Prolonged QTc (as measured by using the Bazett method, where 450 ms was the cut-off for male patients and 460 ms was the cut-off for female patients) is found in 12.9% of the general population, compared with 20.5% of people with CKD 8. The QTc interval increased by an average of 2.9 ms for each milligram increase in serum creatinine 9.…”
Section: Discussionmentioning
confidence: 99%
“…Prolonged QTc (as measured by using the Bazett method, where 450 ms was the cut-off for male patients and 460 ms was the cut-off for female patients) is found in 12.9% of the general population, compared with 20.5% of people with CKD 8. The QTc interval increased by an average of 2.9 ms for each milligram increase in serum creatinine 9.…”
Section: Discussionmentioning
confidence: 99%
“…In a study following 6565 participants for a median of 13.3 years, 22.1% (n ¼ 1452) had CKD, and 14.5% (n ¼ 956) had prolonged QTc. Prolonged QTc was present in 12.9% (n ¼ 658) of subjects without CKD and in 20.5% (n ¼ 298) of those with CKD (p < .0001) [12]. In a population of 154 patients with different stages of CKD, QTc interval prolongation was present in 63.6%.…”
Section: Qtc Interval and Alqtsmentioning
confidence: 93%
“…QTc interval was significantly prolonged across increasing stages of CKD severity (p < .006). Malik et al [12] Study followed 6565 participants with and without CKD. 13.3 years of follow-up.…”
Section: Qtc Interval and Alqtsmentioning
confidence: 99%
See 1 more Smart Citation
“…Baseline QT interval evaluation prior to therapy is important since there is a greater risk of prolongation in individuals with high baseline values. The prevalence of high baseline QT intervals was reported to be 14.5% among those aged ≥40 years in a US population study 55 . And finally, the potential combination of these arrhythmogenic risks may be further exacerbated in the setting of COVID-19, in which the disease is associated with myocardial injury and arrhythmias 56 .…”
Section: Methodsmentioning
confidence: 98%