Association of pyoderma gangrenosum, erythema nodosum and aseptic liver abscess without significant underlying disease

Hanami, Yuka; Mori, Tatsuhiko; Kikuchi, Nobuyuki; Yamamoto, Toshiyuki

doi:10.1111/ced.13838

Cited by 3 publications

(2 citation statements)

References 5 publications

(6 reference statements)

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“…90 Palmoplantar pustulosis, psoriasis, and erythema nodosum have been reported as cutaneous complications of PG. 91,92 Folliculitis may be the initial symptom of PG. If severe acne or suppurative hidradenitis is concurrent, complication by an autoinflammatory disease should be suspected.…”

Section: Underlying Dis E a S E S/ Complic Ations Of Pyoderma G Ang R...mentioning

confidence: 99%

“…There is also a pathological condition called aseptic abscess syndrome, which is an autoinflammatory disease that complicates Crohn's disease and produces sterile abscesses in the spleen and skin accompanied by abdominal pain and fever 90 . Palmoplantar pustulosis, psoriasis, and erythema nodosum have been reported as cutaneous complications of PG 91,92 . Folliculitis may be the initial symptom of PG.…”

Section: Underlying Diseases/complications Of Pyoderma Gangrenosummentioning

confidence: 99%

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Clinical guidance of pyoderma gangrenosum 2022

Yamamoto

Yamasaki

Yamanaka

et al. 2023

The Journal of Dermatology

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Pyoderma gangrenosum (PG) is a rare, neutrophilic skin disease. For the purpose of accurate diagnosis and proper treatment of PG, the Japanese clinical practice guidance for PG developed by the Japanese Dermatological Association was published in 2022. In this guidance, clinical aspects, pathogenesis, current therapies, and clinical questions on PG are described from the viewpoints of current knowledge and evidence‐based medicine. Here, the English version of the Japanese clinical practice guidelines for PG is presented and is intended to be widely referred to in the clinical examination and treatment of PG.

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Section: Underlying Dis E a S E S/ Complic Ations Of Pyoderma G Ang R...mentioning

confidence: 99%

Section: Underlying Diseases/complications Of Pyoderma Gangrenosummentioning

confidence: 99%

Clinical guidance of pyoderma gangrenosum 2022

Yamamoto

Yamasaki

Yamanaka

et al. 2023

The Journal of Dermatology

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Multiple ulcerative colitis-associated aseptic abscesses successfully treated with infliximab: a case report

Toba

Ikegami

Nogami

et al. 2023

Clin J Gastroenterol

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Symptoms and Management of Aseptic Liver Abscesses

Hafner,

Seufferlein,

Kleger

et al. 2023

Z Gastroenterol

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Aseptic liver abscesses occur very rarely. Clinical guidelines on the management of the disease do not exist, and the diagnosis is challenging.We screen MEDLINE and PUBMED databases for relevant case reports from inception to November 2022. Information on patient age, sex, initial symptoms, the extent of abscess formation, further diagnoses, treatment, and course of the disease is analyzed.Thirty cases with sterile hepatic abscess formation are identified. In most patients (n=18), the spleen is affected as well. Patients typically present with fever, abdominal pain, and increased inflammatory values. Comorbidity with inflammatory bowel disease is very common (n=18) and is associated with a significantly younger age at the time of hepatic abscess development. In addition, many patients show autoimmune-mediated cutaneous, ocular, or arthritic rheumatoid manifestations. Histological examination of abscess material reveals neutrophilic infiltration. The majority of patients initially receive corticosteroid therapy. Furthermore, response to azathioprine, anti-TNF-α antibodies, and other immunomodulatory drugs is reported. Ten out of fourteen patients with a long-term follow-up (≥ 36 months) have at least one relapse of hepatic abscess formation.Aseptic hepatic abscesses should be considered in the case of sterile punctures and non-response to antibiotics. Patients with aseptic liver abscesses have a high risk of recurrence warranting immunomodulatory maintenance therapy.

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Association of pyoderma gangrenosum, erythema nodosum and aseptic liver abscess without significant underlying disease

Cited by 3 publications

References 5 publications

Clinical guidance of pyoderma gangrenosum 2022

Clinical guidance of pyoderma gangrenosum 2022

Multiple ulcerative colitis-associated aseptic abscesses successfully treated with infliximab: a case report

Symptoms and Management of Aseptic Liver Abscesses

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