Association of psoriasis and psoriatic arthritis with osteoporosis and pathological fractures

Abstract

Pso and PsA were associated with osteopenia, osteoporosis, ankylosing spondylitis, and pathologic fractures.

Characterization of Bone Metabolism in Hungarian Psoriatic Arthritis Patients: A Case–Control Study.

“…Probability of fragility fractures has not been reported previously in PsA patients using the FRAX tool. Our probability ndings are in concordance with ndings where osteoporotic fractures were studied as primary endpoints, reporting higher odds of diagnosis with pathological fractures and elevated risk of all fractures [22,36,37]. A cross-sectional study from Spain reported increased prevalence of fragility fractures in postmenopausal PsA patients [28].…”

“…PsA patients with an increased risk of low areal bone mineral density [22][23][24][25][26][27]. But simultaneously is in disagreement with another series of studies that did not report low areal BMD [28][29][30][31][32][33].…”

Studying the effect of systemic and biological drugs on intima‐media thickness in patients suffering from moderate and severe psoriasis

“…Psoriasis is a chronic, inflammatory and immunomediated disease resulting in skin condition with an average prevalence of 2% in Europe and North America . Multiple comorbidities have been related to psoriasis, such as inflammatory bowel disease (IBD), diabetes mellitus, non‐alcoholic fatty liver disease or rheumatoid arthritis . This eclectic range of comorbidities is rooted in the altered systemic inflammatory state existent in patients with psoriasis .…”

KLK6 expression in skin induces PAR1-mediated psoriasiform dermatitis and inflammatory joint disease

“…This revealed kyphosis ( Figure 3B), decreased joint space in the sacroiliac joints and pubic symphysis, and erosions in the pubic symphysis in some, but not all, Klk6+ transgenic mice ( Figure 3C and Figure 4B). Transgenic mice also showed significantly (P = 1.4 × 10 -6 ) decreased vertebral bone mineral density ( Figure 3D), which is commonly seen in patients with inflammatory arthritis, including those with PsA (11). H&Estained spine sections revealed thinning of the trabecular bone and subchondral plate, impaired calcification of the vertebral cartilage, and abnormalities of the vertebral disc and surrounding fibrous tissue in Klk6+ transgenic mice ( Figure 3E), supporting our gross and radiographic observations of axial skeleton disease.…”