Association of prostate cancer with human papillomavirus infections: a case-control study

Yin, Shuo-Han; Chung, Shiu-Dong; Hung, Shih-Han; Liu, Tsai-Ching; Lin, Herng-Ching

doi:10.1038/s41391-023-00772-1

Cited by 1 publication

(2 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Subsequent studies showing koilocytosis in PCa tissues suggest a potential role for HPV in PCa etiology [62,63]. Most studies investigating the relationship between HPV and PCa use tissues from patients with benign prostatic hyperplasia (BPH) as the control group [63][64][65][66][67]. While understandable due to the quantitative advantage over normal prostate tissues, this approach can lead to confusion considering that pre-cancerous lesions are often evaluated under the umbrella of BPH.…”

Section: Prostate Cancermentioning

confidence: 99%

“…Research exploring the potential role of HPV in PCa pathogenesis has utilized various methodologies, yet findings remain inconclusive. Traditional PCR-based techniques, commonly employed in prior studies, may lack the sensitivity required to detect past HPV infections, limiting their ability to elucidate the HPV-PCa relationship [63][64][65][66][67]70]. In contrast, a study by Khoury et al, utilizing NGS methods on the Human Genome Atlas database, found no HPV presence in 53 PCa cases [71].…”

Section: Prostate Cancermentioning

confidence: 99%

See 1 more Smart Citation

Unveiling the Role of Human Papillomavirus in Urogenital Carcinogenesis a Comprehensive Review

Karaoğlan,

Ürün

2024

Viruses

View full text Add to dashboard Cite

Human papillomavirus (HPV), an oncogenic DNA virus, is the most common sexually transmitted virus and significant public health concern globally. Despite the substantial prevalence of HPV infection among men, routine testing remains elusive due to the lack of approved HPV tests and the complexity of detection methods. Various studies have explored the link between HPV and genitourinary cancers, revealing different associations influenced by geographic variation, histological subtype and methodological differences. These findings underscore the importance of further research to elucidate the role of HPV in male urogenital cancers. This comprehensive review delves into the intricate relationship between HPV and male genitourinary cancers, shedding light on the virus’s oncogenic mechanisms and its reported prevalence. A deeper understanding of HPV’s implications for male health is essential for advancing public health initiatives and reducing the burden of urogenital cancers worldwide.

show abstract