Association of promoter region polymorphisms of CD209 gene with clinical outcomes of dengue virus infection in Western India

Alagarasu, Kalichamy; Damle, I.M.; Bachal, Rupali; Mulay, A.P.; Shah, P.S.; Cecilia, D.

doi:10.1016/j.meegid.2013.04.024

Cited by 29 publications

(20 citation statements)

References 17 publications

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“…Moreover, the frequency of allele -336G observed in this study was significantly higher than the frequency observed in Asian populations, such as those of eastern China (7.3%) (Zheng et al, 2011), northern Thailand (9.5%) (Wichukchinda et al, 2007), and different regions of Taiwan (Table 2). However, the frequency did not differ from that found in Indonesia (12.7%) (Kobayashi et al, 2011), western and south India (15.9 and 22.3%, respectively) (Selvaraj et al, 2009;Alagarasu et al, 2013), or the Asian portion of Russia (18.4%) (Barkhash et al, 2012). There was no statistically significant difference between the frequencies of allele -336G observed in the present study population and a population from Australia (16%) (Clifford et al, 2011).…”

Section: Discussioncontrasting

confidence: 73%

“…In this context, SNP -336A/G in CD209 could confer greater protection or increased susceptibility to certain infectious diseases (Barreiro et al, 2006;Kashima et al, 2009;Chan et al, 2010;Ryan et al, 2010). However, because some studies have reported contradictory results, the actual effect of SNP -336A/G remains inconclusive in some cases (Wang et al, 2011;Alagarasu et al, 2013;Oliveira et al, 2014), emphasizing the need for validation studies in different populations.…”

Section: Discussionmentioning

confidence: 99%

“…Among the SNPs of interest are those located in the promoter region of CD209. These SNPs can influence the affinity of transcription factors and thus affect the expression of the DC-SIGN receptor (Barreiro et al, 2006;Barkhash et al, 2012;Alagarasu et al, 2013). One of the most well-studied SNPs is a nucleotide transition from adenine (A) to guanine (G) at position -336 (-336A/G, rs4804803) in the promoter region of CD209 (Barreiro et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

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Frequency of SNP -336A/G in the promoter region of CD209 in a population from northeastern Brazil

Pn¹,

Ferreira-Fernandes²,

Js³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Dendritic cells (DCs) mediate the initiation of the immune response against a variety of pathogens. The DC-SIGN receptor is encoded by the gene CD209 and is expressed on the surface of DCs. It binds to mannose-rich carbohydrates and enables the recognition of bacteria, fungi, parasites, and viruses. SNP -336A/G in the promoter region of CD209 influences the expression of the DC-SIGN receptor. Several studies have associated this SNP with an increased susceptibility to infectious diseases and the development of more severe forms of disease. Therefore, the aim of this study was to determine the prevalence of SNP -336A/G in a population from northeastern Brazil. We analyzed 181 individuals from the general population of Parnaíba, Piauí, Brazil, of which 37% were men and 63% were women. SNP -336A/G was detected by polymerase chain reaction and treatment with the restriction enzyme MscI and visualized by electrophoresis on an 8% polyacrylamide gel stained with silver nitrate. Of the individuals analyzed, 116 (64.1%) were homozygous AA, 57 (31.5%) were heterozygous (AG), and 8 (4.4%) were homozygous GG. The allele frequency of -336G was 20.2%. Genotype frequencies were in Hardy-Weinberg equilibrium. To the best of our knowledge, this is the first report to describe the frequency of the CD209 SNP -336A/G in a population in the State of Piauí. Further studies are needed to determine the relationship between this SNP and the vulnerability of this population to major infectious diseases.

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Section: Discussioncontrasting

confidence: 73%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Frequency of SNP -336A/G in the promoter region of CD209 in a population from northeastern Brazil

Pn¹,

Ferreira-Fernandes²,

Js³

et al. 2015

Genet. Mol. Res.

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“…Se ha postulado que los factores virales (6,7), el hecho de que la infección haya estado precedida de otra causada por un serotipo diferente (8), y factores asociados con el huésped, entre ellos los genéti-cos, pueden influir en la proclividad a presentar el dengue grave (8)(9)(10).…”

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Variants in the TNFA, IL6 and IFNG genes are associated with the dengue severity in a sample from Colombian population

et al. 2017

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Introducción. La composición genética del huésped determina, entre otros aspectos, el perfil clínico del dengue, lo cual se debería al efecto de variantes en los genes que codifican citocinas proinflamatorias.Objetivo. Evaluar la asociación entre las variantes de tres polimorfismos en los genes candidatos TNFA, IL6 e IFNG con la gravedad del dengue en una población colombiana.Materiales y métodos. Se evaluaron los polimorfismos rs1800750, rs2069843 y rs2069705 de los genes TNFA, IL6 e IFNG, respectivamente, en 226 pacientes con dengue. Los genotipos se tipificaron usando la reacción en cadena de la polimerasa (PCR) y los polimorfismos de la longitud de los fragmentos de restricción (Restriction Fragment Length Polymorphism, RFLP). Para determinar el riesgo de diferentes fenotipos del dengue, se compararon las frecuencias alélicas con la prueba de ji al cuadrado, y los genotipos y los haplotipos, con regresión logística. Por último, los análisis se ajustaron utilizando datos de autoidentificación o del componente genético ancestral.Resultados. El alelo A del rs2069843, ajustado por autoidentificación, se asoció con casos de dengue hemorrágico en afrocolombianos. En la muestra completa, dicho polimorfismo, ajustado por componente genético ancestral, fue reproducible. Además, hubo asociaciones significativas entre las combinaciones alélicas GGT y GAC de los rs1800750, rs2069843 y rs2069705 en pacientes con dengue hemorrágico, con ajuste por componente genético ancestral y sin él. Además, la combinación alélica AGC produjo 58,03 pg/ml más de interleucina 6 que la GGC, independientemente de los componentes genéticos europeo, amerindio y africano.Conclusión. Las variantes de los polimorfismos GGT y GAC de los rs1800750, rs2069843 y rs2069705 en los genes TNFA, IL6 e IFNG, respectivamente, se correlacionaron con la gravedad del dengue en esta muestra de población colombiana.

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“…Cont.Genotypes for the Rochester cohort, presented as homozygous major allele/heterozygous/homozygous minor allele. N indicates the number of subjects with the specific genotype.Immune outcomes for the Rochester cohort, presented as median neutralizing antibody titer in NT50 6 IQR (inter-quartile range), as measured by the sICNA assay.Ordinal p-value for analysis in the Rochester cohort only, after adjusting for gender, assay batch effect, quartiles of age at enrollment, immunization age, time since last immunization to enrollment, and race-specific population stratification eigenvectors.Genotypes for the San Diego cohort, presented as homozygous major allele/heterozygous/homozygous minor allele. N indicates the number of subjects with the specific genotype.Immune outcomes for the San Diego cohort, presented as median neutralizing antibody titer in NT50 6 IQR (inter-quartile range), as measured by the sICNA assay.Ordinal p-value for analysis in the San Diego cohort only, after adjusting for gender, assay batch effect, quartiles of age at enrollment, immunization age, time since last immunization to enrollment, and race-specific population stratification eigenvectors.Meta-analysis p-value after adjusting for gender, assay batch effect, quartiles of age at enrollment, immunization age, time since last immunization to enrollment, and race-specific population stratification eigenvectors; pooled estimate from the meta analysis showing the magnitude and direction of the estimated effect on the immune measure; homogeneity test p-value estimating the homogeneity between the two cohorts.…”

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confidence: 99%

Associations between Single Nucleotide Polymorphisms in Cellular Viral Receptors and Attachment Factor-Related Genes and Humoral Immunity to Rubella Vaccination

et al. 2014

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BackgroundViral attachment and cell entry host factors are important for viral replication, pathogenesis, and the generation and sustenance of immune responses after infection and/or vaccination, and are plausible genetic regulators of vaccine-induced immunity.MethodsUsing a tag-SNP approach in candidate gene study, we assessed the role of selected cell surface receptor genes, attachment factor-related genes, along with other immune genes in the genetic control of immune response variations after live rubella vaccination in two independent study cohorts.ResultsOur analysis revealed evidence for multiple associations between genetic variants in the PVR, PVRL2, CD209/DC-SIGN, RARB, MOG, IL6 and other immune function-related genes and rubella-specific neutralizing antibodies after vaccination (meta p-value <0.05).ConclusionOur results indicate that multiple SNPs from genes involved in cell adhesion, viral attachment, and viral entry, as well as others in genes involved in signaling and/or immune response regulation, play a role in modulating humoral immune responses following live rubella vaccination.

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Association of promoter region polymorphisms of CD209 gene with clinical outcomes of dengue virus infection in Western India

Cited by 29 publications

References 17 publications

Frequency of SNP -336A/G in the promoter region of CD209 in a population from northeastern Brazil

Frequency of SNP -336A/G in the promoter region of CD209 in a population from northeastern Brazil

Variants in the TNFA, IL6 and IFNG genes are associated with the dengue severity in a sample from Colombian population

Associations between Single Nucleotide Polymorphisms in Cellular Viral Receptors and Attachment Factor-Related Genes and Humoral Immunity to Rubella Vaccination

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