Association of Prolidase Activity, Oxidative Parameters, and Presence of Atrial Fibrillation in Patients with Mitral Stenosis

Rabuş, Murat Bülent; Demirbağ, Recep; Yıldız, Ali; Tezcan, Orhan; Yılmaz, Remzi; Ocak, Ali Rıza; Alp, Mete; Erel, Özcan; Aksoy, Nurten; Yakut, Cevat

doi:10.1016/j.arcmed.2008.03.002

Cited by 18 publications

(10 citation statements)

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“…Low prolidase activity may cause many diseases [ 21 – 24 ]. Mental retardation, extraordinary facial appearance, skeletal deformities, joint dislocations, hematological anomalies, splenomegaly, chronic infections and chronic skin ulcers in particular may be observed due to prolidase deficiency [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

Prolidase activity in chronic plaque psoriasis patients

Sürücü

Aksoy

Ozgöztas

et al. 2015

pdia

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IntroductionPsoriasis is a chronic, inflammatory, T-cell-mediated and hyperproliferative skin disease characterized by erythematous, squamous, sharply circumscribed and infiltrated plaques. The metabolisms of the collagen proteins undergo considerable changes due to the acceleration of their turnovers as a result of increased prolidase activity in psoriasis patients.AimTo determine the level of prolidase activity in psoriasis patients and evaluate its relationship with the oxidative system.Material and methodsThe serum prolidase enzyme activity, total antioxidant levels and total oxidant levels of 40 psoriasis patients and a control group including 47 healthy individuals were analyzed by using their serum samples, and their oxidative stress indices were calculated.ResultsThe prolidase levels (p < 0.01), total oxidant levels (p < 0.01) and oxidative stress index levels (p < 0.001) of the patient group were higher than the corresponding parameters in the control group. The total antioxidant level was low (p < 0.01). Although a positive correlation was found between the prolidase and total antioxidant levels and the total oxidant level, no correlation was found between prolidase and the oxidative stress index.ConclusionsIt has been determined that the activity of the prolidase enzyme increases due to the increased collage turnover in psoriasis patients. Increased serum oxidant levels and oxidative stress indices values may play a role in the pathogenesis of psoriasis.

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Section: Discussionmentioning

confidence: 99%

Prolidase activity in chronic plaque psoriasis patients

Sürücü

Aksoy

Ozgöztas

et al. 2015

pdia

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“…6 Elevated levels in serum are associated with oxidative stress in some organic diseases, such as mitral stenosis, Helicobacter pylori infection, and ovarian cancer. 7,8 Previous studies have investigated prolidase activity under different clinical conditions, such as rheumatic diseases and asthma. 9,10 Carotid atherosclerosis is strongly correlated with coronary atherosclerosis and carotid intima-media thickness (CIMT), as measured by carotid Doppler ultrasound.…”

Section: Introductionmentioning

confidence: 99%

The relationships among the levels of oxidative and antioxidative parameters, FEV1 and prolidase activity in COPD

et al. 2016

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“…Our study showed a significant correlation between SPA levels and atrial fibrillation when the associated factors were evaluated. In a study by Rabus et al [27], it was shown that atrial fibrillation was associated with SPA and oxidative stress in patients with mitral stenosis.…”

Section: Discussionmentioning

confidence: 99%

Serum prolidase enzyme activity as a diagnostic marker for acute ischemic stroke

Tunç¹,

Kotan²,

Akdoğan³

et al. 2018

biomedicalresearch

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Objective: We aimed to investigate whether Serum Prolidase Activity (SPA) levels could be used as a potential diagnostic and/or prognostic biomarker in Acute Ischemic Stroke (AIS) patients or not. Materials and methods: SPA levels were prospectively evaluated in 37 patients aged between 20 and 85 y who were admitted within 24 h of the onset of AIS. The control group included 37 healthy volunteers of similar age without any disease. Results: In AIS patients, mean SPA was significantly higher compared to healthy controls (1331 ± 399 pg/ml vs. 1169 ± 221 pg/ml, respectively; p=0.035). SPA was not correlated with age, gender, hypertension, diabetes, total cholesterol, triglycerides, high-density lipoprotein, low-density lipoprotein, hemoglobin, c-reactive protein, or hemoglobin A1c levels (p>0.05 for all comparisons). However, patients with new diagnostic atrial fibrillation had higher levels of prolidase acitvity than the others (1647 ± 403 pg/ml vs. 1270 ± 384 pg/ml, p=0.032). SPA levels were also uncorrelated with National Institutes of Health Stroke Scale, infarct volume, Trial of Org 10172 and the Oxfordshire Community Stroke Project classifications, and duration of hospitalization (p>0.05, for all comparisons). Conclusions: Increased levels of serum prolidase enzyme activity may be an independent predictor of AIS and may contribute to stroke pathophysiology. However, further studies with larger populations are needed to reveal the role of SPA in AIS.

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Association of Prolidase Activity, Oxidative Parameters, and Presence of Atrial Fibrillation in Patients with Mitral Stenosis

Cited by 18 publications

References 34 publications

Prolidase activity in chronic plaque psoriasis patients

Prolidase activity in chronic plaque psoriasis patients

The relationships among the levels of oxidative and antioxidative parameters, FEV1 and prolidase activity in COPD

Serum prolidase enzyme activity as a diagnostic marker for acute ischemic stroke

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