Association of proinflammatory cytokines and chemotherapy-associated cognitive impairment in breast cancer patients: a multi-centered, prospective, cohort study

Cheung, Yin Ting; Ng, TP; Shwe, Maung; Ho, Han Kiat; Foo, Koon Mian; Cham, Mooi Tai; Lee, J.A.; Fan, Gilbert; Tan, Yee Pin; Yong, Wei Sean; Madhukumar, Preetha; Loo, Sun; Ang, Soo Fan; Wong, Mabel; Chay, Wen Yee; Ooi, Wei; Dent, Rebecca; Yap, Yoon Sim; Ng, Raymond; Chan, Alexandre

doi:10.1093/annonc/mdv206

Cited by 192 publications

(187 citation statements)

References 26 publications

(30 reference statements)

Supporting

Mentioning

157

Contrasting

Unclassified

Order By: Relevance

“…An increased level of IL-6 seems to favor a rise of self-perceived cognitive impairment. In contrast, higher serum levels of IL-4 were associated with improvement in speed performance [31]. A positive relationship has been reported between higher serum levels of IL-6 and an increase of cancer-related fatigue [32].…”

Section: Molecular Underspinning Mechanismsmentioning

confidence: 96%

Section: Molecular Underspinning Mechanismsmentioning

confidence: 99%

“…A positive relationship has been reported between higher serum levels of IL-6 and an increase of cancer-related fatigue [32]. Increased levels of several inflammatory cytokines appear to be a consequence of both cancer itself and anticancer treatment [3,31].Furthermore, it is suspected that the tumor itself may negatively affect cognitive function in different ways [10,27]. Among other aspects, it is suggested that presence of cancer is accompanied by reduced levels of BDNF.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Impact of Physical Inactivity on the Multifactorial Process of Developing Cancer-Related Cognitive Impairments

LM¹,

Zimmer²

2016

J Cancer Sci Ther

View full text Add to dashboard Cite

Many cancer survivors report cognitive impairment before, during and after medical treatment. It is well known that many factors other than chemotherapy take part in the development of these cancer-related cognitive impairments (CRCI), such as cancer-related fatigue, psychological as well as molecular factors. The purpose of this review is to describe the impact of physical inactivity in the genesis of these cognitive changes in cancer patients. References for this narrative review comes primarily from PubMed, Cochrane Library and Livivo databases. It contains literature search from October 2003 to April 2016. Our search was focused on available data for the influence of physical inactivity on cognitive performance of cancer patients. Cancer patients have decreased levels of physical activity during treatment. It is suggested that lack of physical activity in general is associated with cognitive decline. At present, most available data comes from trials with heart failure patients as well as results from bed rest studies in space medicine. The development of CRCI is a multifactorial process with physical inactivity appearing to play an important role. However, the available data remains limited and future trials are needed to examine the specific role of physical inactivity on CRCI.[ [14][15][16]. The role of physical inactivity in the multifactorial process of CRCI development has not been extensively described and is the focus of our review (Figure 1). Materials and MethodsThis narrative review has been divided into four sections: 1) multifactorial aspects generating CRCI, 2) the role of physical inactivity, 3) discussion, and 4) conclusion. Information from this narrative review was obtained by searching the PubMed, Livivo and Cochrane Library databases from October 2003 to June 2016. A first search focuses on the influence of physical inactivity on development of cognitive impairments in cancer patients. Therefore, a combination of following terms was used: on the one hand "cancer-related cognitive decline", "cancer-related cognitive dysfunctions", "cancer-related cognitive impairments", "chemobrain", "chemofog", "post-chemotherapy cognitive impairment", "cancer brain", "cancer associated cognitive impairment", "cancer-therapy-associated cognitive impairment" and on the other hand "bed rest", "immobilization", "lack of exercise", "physical inactivity". There were no publications referring to this aspect exclusively. As such, a second search was conducted focusing on influence of physical inactivity on cognitive performance in general. Therefore, a combination of the following terms was used: "physical inactivity", "bed rest", "immobilization", "lack of exercise" and on the Citation: Pesendorfer LM, Zimmer P, Galvão DA, Bloch W, Baumann FT (2016) Impact of Physical Inactivity on the Multifactorial Process of Developing Cancer-Related Cognitive Impairments. J Cancer Sci Ther 8: 222-227. doi: 10.4172/1948-5956 changes might be associated with impaired memory performance and difficulties in learning [4,5...

show abstract

Section: Molecular Underspinning Mechanismsmentioning

confidence: 96%

Section: Molecular Underspinning Mechanismsmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Impact of Physical Inactivity on the Multifactorial Process of Developing Cancer-Related Cognitive Impairments

LM¹,

Zimmer²

2016

J Cancer Sci Ther

View full text Add to dashboard Cite

show abstract

“…On the other hand, inflammation and immune dysfunction has been associated in the pathology of cognitive dysfunction [1]. It has been reported that the oncologic treatment like chemotherapy leads to increased levels of cytokines [2]. Cytokines produced peripherally can cross the blood brain barrier via saturable transporters or by passive diffusion through spaces between vascular endothelial cells.…”

Section: Risk Factors For Pocd In Cancer Patientsmentioning

confidence: 99%

“…The reported incidence of POCD varies due to lack of formal criteria for diagnosis of POCD. The various factors leading to POCD in cancer patients are demographic factors such as advanced age and comorbidities, genetic, immune factors and treatment related of which surgery and anaesthesia play a significant role [1][2][3][4][5].…”

mentioning

confidence: 99%