Association of Progranulin and High Sensitivity CRP Concentrations in Gingival Crevicular Fluid and Serum in Chronic Periodontitis Subjects with and without Obesity

Pradeep, A.R.; Priyanka, N; Prasad, M. V. R.; Kalra, Nitish; Kumari, Minal

doi:10.1155/2012/173123

Cited by 27 publications

(55 citation statements)

References 33 publications

(41 reference statements)

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“…measured PGRN concentrations in serum and gingival crevicular fluid of 40 patients suffering from chronic periodentitis with and without obesity. The authors reported that the serum PGRN concentration was higher in both serum and gingival crevicular fluid in obese periodentitic patients; which can indicate that inflammation related to periodentitis and obesity may also be associated with PGRN concentration (27). In agreement with these findings, Hossein-Nezhad and cols.…”

Section: Discussionsupporting

confidence: 59%

Progranulin concentration in relation to bone mineral density among obese individuals

Milajerdi¹,

Maghbooli²,

Mohammadi³

et al. 2018

Archives of Endocrinology and Metabolism

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Objective: Adipose tissue, particularly visceral adipose tissue, secretes a variety of cytokines, among which progranulin is a glycoprotein related to the immune system. Along with other secreted proteins, progranulin may be associated with bone mineral density. The aim of this study was to find out whether there are associations between the progranulin and bone mineral density among obese people. Subjects and methods: This cross-sectional study was conducted on 244 obese participants (aged 22-52). Serum progranulin, high sensitive C-reactive protein, oxidised-low dencity lipoprotein, tumor necrosis factor-α, parathormone, vitamin D, and interleukins of 1 β, 4, 6, 10, 13, and 17 concentrations were measured. Anthropometric measurements, body composition and bone mineral density were also assessed. Results: Serum progranulin was directly associated with interleukin-6 and interleukin-1β, while it had a negative association with interleukin-17 and tumor necrosis factor-α. We also observed a statistically significant direct association between progranulin concentration and visceral fat, abdominal fat, waist, abdominal and hip circumferences, hip T-score, and Z-score and T-score for the lumbar region. A partial correlation test has also shown a significant positive correlation regarding serum progranulin and the hip Z-score. Moreover, progranulin level is inversely associated with ospteopenia (P = 0.04 and CI: 0.17,0.96 ). Conclusion: Our study revealed that central obesity may be related to increased progranulin concentration. In addition, progranulin concentration was directly related to bone formation parameters, which indicates the protective effects of progranulin on bone density. Further studies are needed to clarify the exact mechanisms underlying these associations. Arch Endocrinol Metab. 2018;62(2):179-86

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Section: Discussionsupporting

confidence: 59%

Progranulin concentration in relation to bone mineral density among obese individuals

Milajerdi¹,

Maghbooli²,

Mohammadi³

et al. 2018

Archives of Endocrinology and Metabolism

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“…Periodontitis may influence the levels of hs-CRP, and their serum elevation is associated with increased risk of cardiovascular diseases (36) as well as obesity and hyperlipidemia (37)(38)(39). CRP levels >3 mg/L can be classified as high risk of cardiovascular diseases, CRP = 1 to 3 mg/L as medium risk, and CRP <1 mg/L (40) as low risk.…”

Section: Discussionmentioning

confidence: 99%

Lipid profile and high-sensitivity C-reactive protein levels in obese and non-obese subjects undergoing non-surgical periodontal therapy

Zuza¹,

Barroso²,

Fabricio³

et al. 2016

J Oral Sci

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Periodontal treatment may improve the metabolic control of dyslipidemia. The aim of this study was to evaluate the lipid profile and high-sensitivity C-reactive protein (hs-CRP) levels in obese and non-obese patients undergoing periodontal therapy. Patients with generalized chronic periodontitis were divided into obese (n = 28) and non-obese groups (n = 26). The periodontal parameters (visible plaque index, gingival bleeding index, probing depth, clinical attachment level, and bleeding on probing), anthropometric measurements (body mass index, waist circumference, and body fat), and serum analyses (triglycerides, total cholesterol, high-density lipoprotein, low-density lipoprotein, fasting glucose, glycated hemoglobin, and hs-CRP) were measured at baseline and 90 days after periodontal treatment. The results showed that the obese subjects presented alterations in triglycerides, total cholesterol, low-density lipoprotein, and hs-CRP at baseline when compared with non-obese patients (P < 0.05). Periodontal treatment could improve the periodontal parameters in both groups similarly (P > 0.05). Obese subjects showed a significant decrease in the levels of triglycerides, total cholesterol, low-density lipoprotein, and hs-CRP post-therapy (P < 0.05), while non-obese patients showed improvement only in hs-CRP (P < 0.05). In conclusion, periodontal treatment could improve the periodontal parameters and circulating hs-CRP in obese and non-obese subjects. Lipid profile was modified only in obese patients post-therapy. (J Oral Sci 58, [423][424][425][426][427][428][429][430] 2016)

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“…The chronic proinflammatory state with CRP being a biomarker might be the link between obesity and periodontitis finally resulting in tooth loss (Boesing et al, 2009;Pradeep et al, 2012). Tooth loss is the possible consequence of oral disease experiences affected by accumulated inflammatory and environmental factors.…”

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confidence: 99%

Sex Differences of Tooth Loss and Obesity on Systemic Markers of Inflammation

Meisel

Holtfreter

Völzke³

et al. 2014

J Dent Res

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Sex-specific differences in the incidence of periodontitis and tooth loss may be related to different phenotypes of obesity and their associations with low-grade inflammation. The aim of this study was to evaluate associations of adiposity and lowgrade inflammation with tooth loss in men and women. Follow-up data of 2,714 participants from the cohort of Study of Health in Pomerania were analyzed for anthropometric measures, periodontitis, tooth loss, C-reactive protein (CRP), and interleukin 6. Regression analyses were used to estimate the effect of obesity on tooth loss within sex strata. During the follow-up period, men lost more teeth in relation to their obesity status than did women. In contrast, there was a steeper increase in CRP levels across obesity levels in women as compared to men. Incidence rate ratio (IRR) of tooth loss associated with elevated CRP, however, was higher in men (IRR = 1.50; 95% confidence interval [CI]: 1.27, 1.77) than women (IRR = 1.18; 95% CI: 1.02, 1.37). Negative binomial regression with number of lost teeth as outcome revealed dose-response dependencies on body mass index and waist-to-hip ratio. Adjusted for covariates, the IRR of tooth loss associated with the third tertile of waist-to-hip ratio was 1.37 (95% CI: 1.04, 1.80) and 1.53 (95% CI: 1.14, 2.05) in men and women, respectively. Tooth loss related to CRP cutoff of 2 mg/L was significant in men (IRR = 1.33; 95% CI: 1.07, 1.66; p = .006) but not in women (IRR = 0.92; 95% CI: 0.73, 1.17; p = .689). This study suggests that both adiposity and subclinical inflammation affect tooth loss, with distinct differences between men and women. Obesity as a risk factor of tooth loss is particularly related to CRP in men but not in women.

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Association of Progranulin and High Sensitivity CRP Concentrations in Gingival Crevicular Fluid and Serum in Chronic Periodontitis Subjects with and without Obesity

Cited by 27 publications

References 33 publications

Progranulin concentration in relation to bone mineral density among obese individuals

Progranulin concentration in relation to bone mineral density among obese individuals

Lipid profile and high-sensitivity C-reactive protein levels in obese and non-obese subjects undergoing non-surgical periodontal therapy

Sex Differences of Tooth Loss and Obesity on Systemic Markers of Inflammation

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