Association of Pro-inflammatory Dietary Intake and Non-Alcoholic Fatty Liver Disease: Findings from Iranian case-control study

Vahid, Farhad; Shivappa, Nitin; Hekmatdoost, Azita; Hébert, James R.; Shamsipour, Aliakbar; Eslamparast, Tannaz; Meibodi, Mohammad; Rahmani, Diyako

doi:10.1024/0300-9831/a000571

Cited by 21 publications

(20 citation statements)

References 43 publications

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“…In terms of markers of liver function, positive associations between the AE-DII, GGT, ALT and AST were observed. As opposed to prior observations (49,50) , the AE-DII was not associated with increased GGT, AST and ALT levels in the PURE-NWP-SA population through the pathway of obesity/fatty liver disease, as the associations remained after adjustment. Instead the associations appear, at least in part, to be related to alcohol consumption, as adjustment therefore nullified the association between the AE-DII and the liver enzymes.…”

Section: Ae-dii In the Pure-nwp-sa Cohort: The Role Of Urbanicitycontrasting

confidence: 99%

The association between an energy-adjusted dietary inflammatory index and inflammation in rural and urban Black South Africans

Ferreira

Cronjé

Zyl

et al. 2021

Public Health Nutr.

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Objective: To quantify the inflammatory potential of the diet of rural and urban Black South Africans using an adapted energy-adjusted dietary inflammatory index (AE-DII) and to investigate its relationship with inflammatory and cardio-metabolic disease risk markers. Dietary inflammatory potential has not been investigated in African populations. Design: Cross-sectional investigation. Setting: Rural and urban sites in the North West province of South Africa. Participants: 1,885 randomly selected, apparently healthy Black South Africans older than 30 years. Results: AE-DII scores ranged from –3.71 to +5.08 with a mean of +0.37. AE-DII scores were significantly higher in men (0.47±1.19) than in women (0.32±1.29), and in rural (0.55±1.29) than urban participants (0.21±1.19). Apart from its dietary constituents, AE-DII scores primarily associated with age, rural-urban status and education. Contrary to the literature, alcohol consumption was positively associated with AE-DII scores. Of the four tested inflammatory and 13 cardio-metabolic biomarkers, the AE-DII was only significantly negatively associated with albumin and high-density lipoprotein cholesterol, and positively with waist circumference and fasting glucose, upon full adjustment. Conclusion: Rural men consumed the most pro-inflammatory diet, and urban women the least pro-inflammatory diet. The diet of the participants was not overtly pro- or anti-inflammatory and was not associated with measured inflammatory markers. The inflammatory potential of alcohol at different levels of intake requires further research. Understanding dietary inflammatory potential in the context of food insecurity, unhealthy lifestyle practices and lack of dietary variety remains limited.

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Section: Ae-dii In the Pure-nwp-sa Cohort: The Role Of Urbanicitycontrasting

confidence: 99%

The association between an energy-adjusted dietary inflammatory index and inflammation in rural and urban Black South Africans

Ferreira

Cronjé

Zyl

et al. 2021

Public Health Nutr.

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“…In summary a positive association was observed between the DII and endometriosis in this case–control study. One of the possible mechanisms for the positive association between DII and the risk of the endometriosis and other chronic inflammatory states might be through the effect of a pro-inflammatory diet, which is known to increase inflammatory cytokines (IL-1, IL-6, and TNF-α) 39 ; to impair antioxidative cell defense system; and to encourage NF-ΚB dependent pathway. 40 This study adds to evidence suggesting that diet-associated inflammation is involved in the pathophysiology of endometriosis.…”

Section: Discussionmentioning

confidence: 99%

Dietary Inflammatory Index score and risk of developing endometriosis: A case–control study

Silva

Felipe

Shivappa

et al. 2020

Journal of Endometriosis and Pelvic Pain Disorders

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The possible relationship between chronic inflammation from dietary exposure and endometriosis has not been investigated. Thus, the aim of this study was to investigate the association between the Dietary Inflammatory Index (DII®) and endometriosis. Women with endometriotic lesions were defined as cases ( n = 59), and controls ( n = 59) had no visible ectopic endometrium sites. Body mass index (BMI=weight(kg)/height(m)2) was calculated from measured height and weight and waist circumference was measured. A validated semi-quantitative food frequency questionnaire was used to calculate the DII score. Women with endometriosis were younger, thinner; and had a more pro-inflammatory diet and more pain (dysmenorrhea, chronic pelvic pain, deep dyspareunia), than controls. Women with higher DII scores (>0.86) were more likely to have endometriosis and to present with dyspareunia. Results obtained from modeling DII as a categorical variable in relation to risk of endometriosis showed a near tripling of risk (OR = 2.77; 95% CI = 1.13–6.77) for women with DII >0.86 versus those with DII ⩽ 0.86, after adjusting for age and BMI. After multivariable adjustment, women with DII > 0.86 were four times more likely to have endometriosis compared to women with DII ⩽ 0.86 (OR = 4.14; 95% CI= 1.50–11.4). In conclusion, a pro-inflammatory diet was significantly associated with endometriosis.

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“…Individual Intake − Mean SD Table 1 shows the distribution of 82 cases of GC and 95 controls according to the selected variable [7,8]. The mean age was 48.33 ± 10.74 and 51.36 ± 11.81 in the case and the control groups, respectively.…”

Section: Statistical Analysesmentioning

confidence: 99%

“…Given that the therapies for GC are limited, and the survival chance is low, prevention can be a very effective strategy to reduce the mortality from GC [4][5][6]. Several studies have found a link between the incidence of GC and unhealthy diets [7,8]. In addition, the association between dietary antioxidants and the reduction of the incidence and prevalence of GC has been observed [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, the diet's total antioxidant content can provide a comprehensive overview of the relationship between dietary antioxidants and the incidence and/or risk of GC [12]. Several studies have shown that some foods and micronutrients have antioxidant or/and anti-inflammatory properties [7,[13][14][15][16]. Specifically, due to the increase in the incidence and prevalence of various types of cancers, some foods and micronutrient antioxidants are considered more.…”

Section: Introductionmentioning

confidence: 99%

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Validation of Dietary Antioxidant Index (DAI) and investigating the relationship between DAI and the odds of gastric cancer

2020

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Background Gastric cancer (GC) incidence and mortality are rapidly growing worldwide. It is estimated that more than 1,000,000 new cases are diagnosed each year, and more than 78,000 people lose their lives due to GC. The association between dietary antioxidants and GC has been shown in some studies. However, because of the discrepancy between the findings and the lack of a valid indicator, it seems necessary to design and validate the Dietary Antioxidant Index (DAI) to examine the diet's total antioxidant content. The present study aimed to survey the validity of DAI and its association with the odds of GC. Methods In this hospital-based case–control study, 82 patients with GC and 95 healthy controls were examined. We used a 168-item food frequency questioner to assess dietary intakes. The DAI was calculated based on the intake of vitamin A, C, E, and selenium, manganese, and zinc. We standardized each of the six vitamins and minerals by subtracting the global mean and dividing by the global standard deviation to calculate DAI. We then calculated the DAI by summing up the standardized intakes of these vitamins and minerals of the individuals with equal weight. Results We observed a significant correlation between DAI and total antioxidant capacity (TAC) after controlling for age, body mass index (BMI), energy intake, smoking and fasting blood sugar, education, total fat intake, helicobacter pylori infection, total cholesterol, and saturated fatty acid (SFA) intakes. Results obtained from modeling DAI as a continuous variable in relation to GC showed a negative association after adjustment for age and in the multivariable analysis (OR = 0.64, CI = 0.43–0.95). Conclusion DAI is a valid indicator of dietary antioxidants assessments, and it can be used as a predictor of antioxidant status due to its correlation with serum antioxidant levels. The results showed that dietary antioxidants have a significant relationship with GC, which indicates the importance of antioxidants in this cancer's etiology.

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Association of Pro-inflammatory Dietary Intake and Non-Alcoholic Fatty Liver Disease: Findings from Iranian case-control study

Cited by 21 publications

References 43 publications

The association between an energy-adjusted dietary inflammatory index and inflammation in rural and urban Black South Africans

The association between an energy-adjusted dietary inflammatory index and inflammation in rural and urban Black South Africans

Dietary Inflammatory Index score and risk of developing endometriosis: A case–control study

Validation of Dietary Antioxidant Index (DAI) and investigating the relationship between DAI and the odds of gastric cancer

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