Association of pro-inflammatory cytokine gene polymorphisms with schizophrenia in South Indian population

Srinivas, Lekshmy; Neetha, N. V.; Nair, Chandrasekharan M.; Allencherry, Priya M; Banerjee, Moinak

doi:10.1186/1755-8166-7-s1-p41

Cited by 2 publications

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“…Schizophrenia is a common mental disorder in Namibia and affects about 20 million people worldwide. People with schizophrenia have 40% -60% greater chances of dying than the general population According to Srinivas, Neetha, Nair, Allencherry & Banerjee (2013), schizophrenia is a severe and disabling mental illness, that affects the brain, whereby a person sees or hears things that are actually not there. People suffering from schizophrenia struggle with differentiating between what is real and what is unreal, they find it difficult to think clearly and to behave normally.…”

Section: Introductionmentioning

confidence: 99%

A Logistic Regression Model to Assess Factors Influencing Schizophrenia Symptoms in Namibia

Nakunipa

Pazvakawambwa

Iiyambo

2022

NJRST

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Schizophrenia is a common mental disorder in Namibia and affects about 20 million people worldwide. Risk factors for schizophrenia in Namibia have not been extensively investigated. The objective of the study was to establish prevalence and factors influencing schizophrenia symptoms based on secondary data from the 2013 Namibia Demographic and Health Survey (NDHS). Descriptive statistics were computed to profile the background characteristics of the sample. Chi-square tests were conducted to assess association between socio-demographic variables and schizophrenia symptoms. Binary logistic regression was performed to establish determinants of schizophrenia symptoms. The prevalence of schizophrenia symptoms was 12.4% (13.6% among females and 11.0% among males). Regression results indicated that females (OR=1.159, 95% CI: 1.022-1.314, p=0.021) were more likely to have schizophrenia symptoms compared to their male counterparts. Those who resided in urban areas (OR=0.699, 95% CI: 0.609-0.803, p<0.001) were less likely to have schizophrenia symptoms compared to those who resided in rural areas. Those with no formal education (OR=0.378, 95% 0.273-0.523, p<0.001); those with primary education (OR=0.646, 95% CI: 0.501-0.834, p<0.001) and those with secondary education (OR=0.619, 95% CI: 0.495-0.775, p<0.001) were less likely to have schizophrenia symptoms compared to those with higher education. Results also showed that those who had never married (OR=0.275, 95% CI: 0.225-0.335, p<0.001); the married (OR=0.229, 95% CI: 0.184-0.284, p<0.001); and those living with a partner (OR=0.283, 95% CI: 0.225-0.355, p<0.001) were less likely to have schizophrenia symptoms compared to those who were on separation. Respondents who did not consume alcoholic drinks (OR=0.597, 95% CI: 0.526-0.677, p<0.001) were less likely to have schizophrenia symptoms compared to those who consumed alcoholic drinks. Schizophrenia symptoms were not significantly influenced by wealth index (p>0.05). There is need to step up gender-specific mental health programs especially in rural areas. Efforts to stabilize marital relationships at national level should be strengthened. Mental health could also be improved through drug abuse prevention and rehabilitation programs.

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Section: Introductionmentioning

confidence: 99%

A Logistic Regression Model to Assess Factors Influencing Schizophrenia Symptoms in Namibia

Nakunipa

Pazvakawambwa

Iiyambo

2022

NJRST

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“…There are various reports suggesting the influence of cytokine gene polymorphisms on plasma cytokine levels in HIV infected and exposed uninfected individuals 7–9 . Cytokine gene polymorphisms have been studied in different diseases such as HIV, TB, HCV, RM, and IBD from India 7,10–13 . However, not a single report addresses this aspect in HIV‐1 positive and exposed uninfected (EU) infants born to HIV‐1 positive mothers.…”

Section: Introductionmentioning

confidence: 99%

“…[7][8][9] Cytokine gene polymorphisms have been studied in different diseases such as HIV, TB, HCV, RM, and IBD from India. 7,[10][11][12][13] However, not a single report addresses this aspect in HIV-1 positive and exposed uninfected (EU) infants born to HIV-1 positive mothers. In this prospective cohort study, we aimed to evaluate the association of Th1 cytokine gene polymorphisms and their effect on plasma cytokine levels in a cohort of HIV-1 infected and exposed uninfected (EU) infants from Mumbai, a metropolitan city of Western India.…”

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confidence: 99%

Th1 cytokine gene polymorphism and the corresponding plasma cytokine levels: A comparative study in HIV‐1 positive and exposed uninfected infants

Chavan

Ahir

Kerkar

et al. 2021

Journal of Medical Virology

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The pro-inflammatory (Th1) cytokines namely interleukin (IL)-2, IL-6, IL-12, interferon (IFN)-γ, tumor necrosis factor-α (TNF-α) are vital in the clearance of HIV infection. This prospective cohort study aimed to evaluate the polymorphisms of Th1 cytokine genes and their corresponding plasma cytokine levels in HIV-1 positive and exposed uninfected (EU) infants born to HIV-1 positive mothers. CD4 count, viral load of HIV-1 positive mothers was done using commercially available reagents.Cytokine genotyping analysis and levels were done in 20 HIV-1 positive and 54 EU infants. The polymorphisms of Th1 cytokines were done using the PCR-SSP method.Plasma cytokine levels were estimated using Bio-Plex-Pro cytokine assay (BIO-RAD; USA). Results revealed treatment status of the mothers and viral load were the two confounding factors having a significant effect on HIV status of the infant. TNF-α GG genotype is significantly higher in EU infants as compared with HIV-1 positive infants. GG genotype was associated with high TNF-α levels in HIV-1 positive infants but the difference was not statistically significant. HIV-1 positive infants with -IFN-γ (+874) TT genotype was significantly associated with high IFN-γ levels. To the best of our knowledge, this is the first study reporting the role of Th1 cytokine gene polymorphisms and their corresponding plasma cytokine levels in HIV-1 positive and EU infants from India.

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Association of pro-inflammatory cytokine gene polymorphisms with schizophrenia in South Indian population

Cited by 2 publications

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A Logistic Regression Model to Assess Factors Influencing Schizophrenia Symptoms in Namibia

A Logistic Regression Model to Assess Factors Influencing Schizophrenia Symptoms in Namibia

Th1 cytokine gene polymorphism and the corresponding plasma cytokine levels: A comparative study in HIV‐1 positive and exposed uninfected infants

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