Association of primary cutaneous amyloidosis with atopic dermatitis: a nationwide population-based study in Taiwan

Lee, D.D.; Huang, Ching-Wen; Ko, Po‐Jen; Chang, Yun Ting; Sun, Wei‐Zen; Oyang, Yen-Jen

doi:10.1111/j.1365-2133.2010.10024.x

Cited by 22 publications

(29 citation statements)

References 33 publications

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“…The diagnosis of PCA is usually straightforward, especially if the morphology and distribution of lesions are typical 1,7 . However, if the area of involvement is located over an unusual site, it becomes difficult to make an accurate diagnosis.…”

Section: Discussionmentioning

confidence: 99%

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Characteristic dermoscopic features of primary cutaneous amyloidosis: a study of 35 cases

Chuang

Lee

Lin

et al. 2012

British Journal of Dermatology

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Section: Discussionmentioning

confidence: 99%

“…In Taiwan PCA is usually diagnosed clinically due to its common occurrence (mean 1‐year prevalence, 0·98 per 10 000 persons) 6,7 . However, similar clinical pictures do occur in other cutaneous diseases.…”

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confidence: 99%

Characteristic dermoscopic features of primary cutaneous amyloidosis: a study of 35 cases

Chuang

Lee

Lin

et al. 2012

British Journal of Dermatology

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“…9 A study in Taiwan showed diabetes to be an important comorbidity among patients with PLCA. 10 Hypothyroidism was seen in three (7.9%) patients. Coexistence of macular amyloidosis and hypothyroidism in Indian women has been reported.…”

Section: Discussionmentioning

confidence: 98%

A Clinical and Histopathological Study of Cutaneous Amyloidosis

E¹,

S²,

Nandakumar³

2017

jemds

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BACKGROUNDCutaneous amyloidosis refers to deposition of amyloid in the skin and can be primary or secondary. Systemic amyloidosis can also have skin involvement with amyloid deposits. Aims-1) To study the clinical presentation and the histopathological features of different types of cutaneous amyloidosis; 2) To study the association of cutaneous amyloidosis with other diseases; 3) To analyse the possible role of friction in inducing the condition. MATERIALS AND METHODSAll such patients during a period of one year were subjected to a detailed history taking, clinical examination, blood and urine investigations and histopathological evaluation including special stain for amyloid. Only biopsy-proven, Congo red positive cases were included in the study. Statistical Analysis: Method used was descriptive statistics. Design and Setting-The study is a case series of patients with clinical and histopathological features of cutaneous amyloidosis attending the outpatient wing of Department of Dermatology and Venereology, in a tertiary care teaching hospital. RESULTSThe clinical and histopathological features were studied and associations with other diseases were noted -26.3% had pre-existing pruritic skin diseases, 10.5% were diabetic and 7.9% were hypothyroid. History of usage of bath scrub was obtained from 76% patients and may be considered a major factor in the development of the condition. Limitations of the Study-Level of significance was not calculated to confirm associations assessed in this study. CONCLUSIONHistopathology is helpful to differentiate between macular and lichen amyloidosis. Cutaneous amyloidosis may often be associated with systemic disorders and hence must prompt one to investigate for them. Avoiding friction to the skin like use of bath-scrubs may help in preventing development of primary cutaneous amyloidosis.

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“…Several previous studies have reported that PLCA is more common among women. 2,4 Lee et al 18 thought that sampling bias might exist, as most previous studies were based either on personal observation or on data collected from a single hospital. In our study, the number of female and male patients was almost equal, for both the familial and sporadic cases.…”

Section: Discussionmentioning

confidence: 99%

Clinical and genetic features of Chinese patients with lichen and macular primary localized cutaneous amyloidosis

Lü

Rong

et al. 2019

Clin Exp Dermatol

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Summary Background Primary localized cutaneous amyloidosis (PLCA) is a chronic pruritic skin disorder. The genetic basis of familial (f)PLCA involves mutations in the oncostatin M receptor (OSMR) and interleukin‐31 receptor A (IL31RA) genes, but the disease pathophysiology is not fully understood. Aim To investigate the OSMR mutation spectrum in patients with sporadic (s)PLCA/fPLCA, lichen/macular PLCA in mainland China. Methods This study was carried out on 64 patients with sPLCA, along with 36 with fPLCA and 10 unaffected individuals collected from 23 unrelated Chinese families. Genomic DNA was extracted from peripheral blood samples. Mutation screening of 17 OSMR exons was performed by Sanger sequencing. Results PLCA lesions are typically localized to the shins, forearm and back. Sequence analysis of OSMR exons demonstrated that the OSMR missense mutation rate in patients with fPLCA (63.89%) was significantly higher than that in patients with sPLCA (34.38%). The male/female ratio of patients carrying a homozygous OSMR mutation (0.29) was significantly lower than that of patients carrying a heterozygous OSMR mutation (1.08; P < 0.05) and of patients with wildtype OSMR (1.75; P < 0.01). Age of onset of PLCA with OSMR homozygous mutation (median age 20 years) was earlier than that of PLCA with OSMR heterozygous mutation (median age 32 years; P < 0.01) or PLCA with wildtype genotype (median age 32 years; P < 0.01). Conclusion The present data indicate OSMR mutations as not only the main cause of fPLCA, but also the potential source of the pathogenesis of sPLCA, although the exact molecular mechanism remains unknown.

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Association of primary cutaneous amyloidosis with atopic dermatitis: a nationwide population-based study in Taiwan

Abstract: This is the first nationwide population-based epidemiological study of PCA. We demonstrate that PCA can be associated with other disorders, especially AD.

Cited by 22 publications

References 33 publications

Characteristic dermoscopic features of primary cutaneous amyloidosis: a study of 35 cases

Characteristic dermoscopic features of primary cutaneous amyloidosis: a study of 35 cases

A Clinical and Histopathological Study of Cutaneous Amyloidosis

Clinical and genetic features of Chinese patients with lichen and macular primary localized cutaneous amyloidosis

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