Association of preoperative uric acid and acute kidney injury following cardiovascular surgery

Joung, Kyoung Woon; Jo, Jun-Young; Hahm, Kyung‐Don; Sim, Jeremiah; Lee, E.-H.; Choi, In‐Cheol

doi:10.1097/00003643-201406001-00159

European Journal of Anaesthesiology

2014

DOI: 10.1097/00003643-201406001-00159

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Association of preoperative uric acid and acute kidney injury following cardiovascular surgery

Kyoung Woon Joung

Jun-Young Jo

Kyung‐Don Hahm

et al.

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“…dependent predictor of AKI [6][7][8][9] , findings that were also confirmed by others [10,11] . In a pilot interventional study it was found that lowering hyperuricemia resulted in less renal structural injury as measured by the AKI biomarker neutrophil gelatinase-associated lipocalin (NGAL) [12] .…”

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confidence: 85%

Effects of Serum Uric Acid on Estimated GFR in Cardiac Surgery Patients: A Pilot Study

Ejaz

Alquadan²,

Dass³

et al. 2015

Am J Nephrol

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Background: The aim of the study was to investigate the effects of serum uric acid (SUA) on acute kidney injury (AKI) in patients undergoing cardiac surgery. Methods: Prospectively collected data from a previous study were analyzed to investigate the relationship between SUA and AKI as assessed by neutrophil gelatinase-associated lipocalin (NGAL), serum creatinine (SCr) and kinetic estimated glomerular filtration rate (KeGFR). Results: Patients undergoing cardiovascular surgery (n = 37) were included. SUA was measured at postoperative 1 h. Statistically significant correlations were present between SUA and NGAL measured at postoperative 1 h (r = 0.39, p = 0.008), 6 h (r = 0.31, p = 0.029) and 24 h (r = 0.31, p < 0.001), respectively. Significant correlations were also noted between SUA and SCr measured on postoperative day 1 (r = 0.41, p = 0.006), day 2 (r = 0.29, p = 0.042) and day 3 (r = 0.42, p = 0.009). Negative correlations were demonstrated between SUA and day 1 (r = -0.44, p = 0.007), day 2 (r = -0.43, p = 0.007), day 3 (r = -0.44, p = 0.006 and day 4 KeGFR (r = -0.35, p = 0.035). The inverse relationship of SUA and KeGFR was also demonstrated with a different method (Jelliffe) of measurement. Conclusions: A reduction in glomerular filtration rate (GFR) can lead to a rise in SUA. However, in this study, we are able to show that SUA at 1 h (maximal dilution time) effectively predicts subsequent changes in urinary NGAL, SCr, KeGFR, and the development of AKI. Thus, these findings suggest that uric acid precedes and predicts acute changes in renal function and cannot be ascribed to a simple relationship in which a reduced GFR raises SUA.

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supporting

confidence: 85%

Effects of Serum Uric Acid on Estimated GFR in Cardiac Surgery Patients: A Pilot Study

Ejaz

Alquadan²,

Dass³

et al. 2015

Am J Nephrol

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Association of preoperative uric acid and acute kidney injury following cardiovascular surgery

Cited by 1 publication

References 0 publications

Effects of Serum Uric Acid on Estimated GFR in Cardiac Surgery Patients: A Pilot Study

Effects of Serum Uric Acid on Estimated GFR in Cardiac Surgery Patients: A Pilot Study

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