Abstract:ObjectiveTo systematically evaluate the association of prenatal thoracic ultrasound abnormalities with copy number variants (CNVs).MethodsChromosomal microarray (CMA) data and clinical characteristics from fetuses with thoracic ultrasound abnormalities were retrieved and analyzed.ResultsThoracic ultrasound findings were mainly isolated except for fetal pleural effusion (FPE) and pulmonary hypoplasia. The diagnostic yield of CMA for thoracic anomaly was 9.66%, and FPE (17/68, 25%), pulmonary hypoplasia (1/8, 12… Show more
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