Association of prenatal and early childhood stress with reduced lung function in 7-year-olds

Lee, Alison G.; Chiu, Yueh-Hsiu Mathilda; Rosa, Maria José; Cohen, Sheldon; Coull, Brent A.; Wright, Robert O.; Morgan, Wayne J.; Wright, Rosalind J.

doi:10.1016/j.anai.2017.05.025

Cited by 30 publications

(18 citation statements)

References 54 publications

(60 reference statements)

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“…The direction of associations between lower maternal education and lung function in our study was unexpected and not consistent with the weight of existing evidence regarding socio‐economic status (SES) and child health . While we do not have a good explanation for these findings, it could be chance findings in the context of multiple comparisons or inaccurate measurement of maternal education.…”

Section: Discussioncontrasting

confidence: 94%

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Early life exposure to coal mine fire smoke emissions and altered lung function in young children

et al. 2019

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Background and objective Long‐term respiratory risks following exposure to relatively short periods of poor air quality early in life are unknown. We aimed to evaluate the association between exposure to a 6‐week episode of air pollution from a coal mine fire in children aged <2 years, and their lung function 3 years after the fire. Methods We conducted a prospective cohort study. Individual exposure to 24‐h average and peak concentrations of particulate matter with an aerodynamic diameter <2.5 μm in diameter (PM2.5) during the fire were estimated using dispersion and chemical transport modelling. Lung function was measured using the forced oscillation technique (FOT), generating standardized Z‐scores for resistance and reactance at a frequency of 5 Hz (Rrs5 and Xrs5), and area under the reactance curve (AX). We used linear regression models to assess the associations between PM2.5 exposure and lung function, adjusted for potential confounders. Results Of the 203 infants originally recruited, 84 aged 4.3 ± 0.5 years completed FOT testing. Median (interquartile range, IQR) for average and peak PM2.5 were 7.9 (6.8–16.8) and 103.4 (60.6–150.7) μg/m3, respectively. The mean ± SD Z‐scores for Rrs5, Xrs5 and AX were 0.56 ± 0.80, –0.76 ± 0.88 and 0.72 ± 0.92, respectively. After adjustment for potential confounders including maternal smoking during pregnancy, a 10 μg/m3 increase in average PM2.5 was significantly associated with worsening AX (β‐coefficient: 0.260; 95% CI: 0.019, 0.502), while the association between a 100‐μg/m3 increase in peak PM2.5 and AX was borderline (0.166; 95% CI: −0.002, 0.334). Conclusion Infant exposure to coal mine fire emissions could be associated with long‐term impairment of lung reactance.

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Section: Discussioncontrasting

confidence: 94%

“…All covariates were selected a priori according to the existing literature (Appendix S1, Supplementary Information).…”

Section: Methodsmentioning

confidence: 99%

Early life exposure to coal mine fire smoke emissions and altered lung function in young children

et al. 2019

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“…Lee et al found negative associations between PNLEs and several indicators of lung function at age 7 ( N = 199), with no evidence of sex-dependent associations [28]. A second paper by this group ( N = 765) showed a sex-dependent association whereby PNLEs were associated with increased odds of asthma at age 4 in boys but not girls.…”

Section: Resultsmentioning

confidence: 99%

Sex Differences in Vulnerability to Prenatal Stress: a Review of the Recent Literature

Sutherland

Brunwasser

2018

Curr Psychiatry Rep

127

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Most articles (k = 35) found evidence of either sex-specific associations (significant in one sex but not the other) or significant PNMSstress interactions for at least one child health outcome. Evidence for sex-dependent effects was strongest in the group of studies evaluating child neural/nervous system development and temperament as outcomes. There is sufficient evidence of sex-dependent associations to recommend that researchers always consider the potential role of child sex in PNMS programming studies and report descriptive statistics for study outcomes stratified by child biological sex.

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“…Epidemiological studies in humans and early life stress models in rodent (e.g. neonatal maternal separation stress) show a link between early life stress/adversity and long-term development of lung immunology, function and respiratory disease risk later in life (Bhan et al, 2014;Hupa et al, 2014;Lee et al, 2017).…”

Section: Innovation In the North American Pork Industrymentioning

confidence: 99%

Review: innovation through research in the North American pork industry

Boyd

Zier-Rush²,

Moeser

et al. 2019

Animal

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This article involved a broad search of applied sciences for milestone technologies we deem to be the most significant innovations applied by the North American pork industry, during the past 10 to 12 years. Several innovations shifted the trajectory of improvement or resolved significant production limitations. Each is being integrated into practice, with the exception being gene editing technology, which is undergoing the federal approval process. Advances in molecular genomics have been applied to gene editing for control of porcine reproductive and respiratory syndrome and to identify piglet genome contributions from each parent. Post-cervical artificial insemination technology is not novel, but this technology is now used extensively to accelerate the rate of genetic progress. A milestone was achieved with the discovery that dietary essential fatty acids, during lactation, were limiting reproduction. Their provision resulted in a dose-related response for pregnancy, pregnancy maintenance and litter size, especially in maturing sows and ultimately resolved seasonal infertility. The benefit of segregated early weaning (12 to 14 days of age) was realized for specific pathogen removal for genetic nucleus and multiplication. Application was premature for commercial practice, as piglet mortality and morbidity increased. Early weaning impairs intestinal barrier and mucosal innate immune development, which coincides with diminished resilience to pathogens and viability later in life. Two important milestones were achieved to improve precision nutrition for growing pigs. The first involved the updated publication of the National Research Council nutrient requirements for pigs, a collaboration between scientists from America and Canada. Precision nutrition advanced further when ingredient description, for metabolically available amino acids and net energy (by source plant), became a private sector nutrition product. The past decade also led to fortuitous discoveries of health-improving components in ingredients (xylanase, soybeans). Finally, two technologies converged to facilitate timely detection of multiple pathogens in a population: oral fluids sampling and polymerase chain reaction (PCR) for pathogen analysis. Most critical diseases in North America are now routinely monitored by oral fluid sampling and prepared for analysis using PCR methods.

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Association of prenatal and early childhood stress with reduced lung function in 7-year-olds

Cited by 30 publications

References 54 publications

Early life exposure to coal mine fire smoke emissions and altered lung function in young children

Early life exposure to coal mine fire smoke emissions and altered lung function in young children

Sex Differences in Vulnerability to Prenatal Stress: a Review of the Recent Literature

Review: innovation through research in the North American pork industry

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