Association of Prematurity and Low Birth Weight with Gestational Exposure to PM2.5 and PM10 Particulate Matter in Chileans Newborns

Rodríguez‐Fernández, Alejandra; Ramos-Castillo, Natalia; Fuente, Marcela Ruíz-De la; Parra‐Flores, Julio; Maury‐Sintjago, Eduard

doi:10.3390/ijerph19106133

Cited by 15 publications

(19 citation statements)

References 19 publications

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“…It should be noticed that birthweight increase should not be equal to better outcomes and high birthweight entailed higher risks of mortality and morbidity ( 35 ). The wide range of monthly-average PM 2.5 in our study could cover from 0 to 210 μg/m 3 , while PM 2.5 levels in many developed countries as well as some developing countries were far less than that in China ( 24 , 25 , 37 ). The restricted cubic spline curves generally presented an increasing trend, although appeared to reach a plateau at about 50-60 μg/m 3 of PM 2.5 (at the mild level).…”

Section: Discussionmentioning

confidence: 57%

“…However, studies on the adverse effects of gestational PM 2.5 exposure on birthweight can be controversial and inconsistent ( 17 , 18 ). Majority of studies demonstrated correlations between PM 2.5 and low birthweight or small for gestational age (SGA) ( 19 – 25 ), while some studies confirmed associations between PM2.5 and LGA or macrosomia ( 10 , 17 , 18 , 26 ). Previous studies pointed out that marked differences on PM 2.5 pollution between rapidly developing and developed countries might cause inconsistency in results ( 17 , 18 ).…”

Section: Introductionmentioning

confidence: 99%

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Interaction of PM2.5 and pre-pregnancy body mass index on birth weight: A nationwide prospective cohort study

Sun

Zhang

et al. 2022

Front. Endocrinol.

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BackgroundFine particulate matter (PM2.5), one of the most common air pollutants worldwide, has been associated with many adverse birth outcomes in some studies. Pre-pregnancy body mass index (BMI) is an important indicator of maternal obesity that may also contribute to a wide range of birthweight outcomes. Both PM2.5 and maternal obesity have been found associated with issues on neonatal birthweight respectively, and more attentions and interests are focusing on their combined effect on pregnancy outcomes.PurposeTo explore the modifying effect of pre-pregnancy BMI on the association between gestational PM2.5 and birthweight; to investigate the interactive effect between gestational PM2.5 and pre-pregnancy BMI on birthweight among pregnant women during three trimesters and the whole pregnancy.MethodsThis nationwide cohort study used the National Free Preconception Health Examination Project (NFPHEP) data collected from January 1, 2010, to December 31, 2012. A total population of 248,501 Chinese women from 220 counties registered this project. Pre-pregnancy BMI as a common anthropometric examination was collected during preconception investigation, and gestational PM2.5 was derived from a hindcast model for historical PM2.5 estimation from satellite-retrieved aerosol optic depth. Subgroup analysis was conducted to explore a potential modifying effect on the association between PM2.5 and birthweight during pregnancy by four pre-pregnancy BMI subgroups. Interaction analysis by introducing product terms to multivariable linear regression was also used to examine whether there was an interactive relationship between PM2.5 and pre-pregnancy BMI.ResultsTotally, 193,461 participants were included in our study. The average concentration of PM2.5 was 75.33 μg/m3. Higher exposure of PM2.5 during the entire pregnancy was associated with higher birthweight (17.15 g per 10 μg/m3; 95% CI:16.15, 18.17). Each 10 μg/m3 increase in PM2.5 during the first, second, and third trimesters was associated with increases in birthweight by 14.93 g (95%CI: 13.96, 15.89), 13.75 g (95% CI: 12.81, 14.69), and 8.79 g (95% CI: 8.09, 9.49), respectively. Higher pre-pregnancy BMI per kg/m2 was associated with an increase of birthweight by 7.012 g (95% CI: 6.121, 7.902). Product terms between PM2.5 and pre-pregnancy BMI were significant for the first, second trimesters, and the entire duration of pregnancy.ConclusionsOur results found both gestational PM2.5 exposure and pre-pregnancy BMI respectively correlated with the increase of birthweight. A negative interaction between pre-pregnancy BMI and gestational PM2.5 was discovered in term of birthweight gain. Avoidance of high-dose exposure to PM2.5 during the early and middle stages of pregnancy and pre-pregnancy overweight/obesity may help prevent high birthweight.

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Section: Discussionmentioning

confidence: 57%

Section: Introductionmentioning

confidence: 99%

Interaction of PM2.5 and pre-pregnancy body mass index on birth weight: A nationwide prospective cohort study

Sun

Zhang

et al. 2022

Front. Endocrinol.

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“…The systematic review comprised a total of 69 papers [ 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 ,…”

Section: Resultsunclassified

Does Exposure to Ambient Air Pollution Affect Gestational Age and Newborn Weight?—A Systematic Review

Grabowski,

Feduniw,

Orzel

et al. 2024

Healthcare

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Current evidence suggests that airborne pollutants have a detrimental effect on fetal growth through the emergence of small for gestational age (SGA) or term low birth weight (TLBW). The study’s objective was to critically evaluate the available literature on the association between environmental pollution and the incidence of SGA or TLBW occurrence. A comprehensive literature search was conducted across Pubmed/MEDLINE, Web of Science, Cochrane Library, EMBASE, and Google Scholar using predefined inclusion and exclusion criteria. The methodology adhered to the PRISMA guidelines. The systematic review protocol was registered in PROSPERO with ID number: CRD42022329624. As a result, 69 selected papers described the influence of environmental pollutants on SGA and TLBW occurrence with an Odds Ratios (ORs) of 1.138 for particulate matter ≤ 10 μm (PM10), 1.338 for particulate matter ≤ 2.5 μm (PM2.5), 1.173 for ozone (O3), 1.287 for sulfur dioxide (SO2), and 1.226 for carbon monoxide (CO). All eight studies analyzed validated that exposure to volatile organic compounds (VOCs) is a risk factor for SGA or TLBW. Pregnant women in the high-risk group of SGA occurrence, i.e., those living in urban areas or close to sources of pollution, are at an increased risk of complications. Understanding the exact exposure time of pregnant women could help improve prenatal care and timely intervention for fetuses with SGA. Nevertheless, the pervasive air pollution underscored in our findings suggests a pressing need for adaptive measures in everyday life to mitigate worldwide environmental pollution.

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“…A cross-sectional analytical project comprising 595,369 Chilean newborns investigated the connection between LBW and gestational exposure to PM 2.5 and PM 10 . The investigation concluded that PM 2.5 exposure during the second trimester was associated with a higher likelihood of LBW (OR: 1.031; 95% CI: 1.004–1.059), whereas PM 10 had an impact on the entire duration of pregnancy [ 24 ]. These findings strongly support the correlation between urban air pollution exposure and LBW as well as diminished fetal growth.…”

Section: Adverse Birth Outcomes Induced By Pm 25mentioning

confidence: 99%

Developmental Toxicity of Fine Particulate Matter: Multifaceted Exploration from Epidemiological and Laboratory Perspectives

Yan,

Ma,

Liu

et al. 2024

Toxics

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Particulate matter of size ≤ 2.5 μm (PM2.5) is a critical environmental threat that considerably contributes to the global disease burden. However, accompanied by the rapid research progress in this field, the existing research on developmental toxicity is still constrained by limited data sources, varying quality, and insufficient in-depth mechanistic analysis. This review includes the currently available epidemiological and laboratory evidence and comprehensively characterizes the adverse effects of PM2.5 on developing individuals in different regions and various pollution sources. In addition, this review explores the effect of PM2.5 exposure to individuals of different ethnicities, genders, and socioeconomic levels on adverse birth outcomes and cardiopulmonary and neurological development. Furthermore, the molecular mechanisms involved in the adverse health effects of PM2.5 primarily encompass transcriptional and translational regulation, oxidative stress, inflammatory response, and epigenetic modulation. The primary findings and novel perspectives regarding the association between public health and PM2.5 were examined, highlighting the need for future studies to explore its sources, composition, and sex-specific effects. Additionally, further research is required to delve deeper into the more intricate underlying mechanisms to effectively prevent or mitigate the harmful effects of air pollution on human health.

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Association of Prematurity and Low Birth Weight with Gestational Exposure to PM2.5 and PM10 Particulate Matter in Chileans Newborns

Cited by 15 publications

References 19 publications

Interaction of PM2.5 and pre-pregnancy body mass index on birth weight: A nationwide prospective cohort study

Interaction of PM2.5 and pre-pregnancy body mass index on birth weight: A nationwide prospective cohort study

Does Exposure to Ambient Air Pollution Affect Gestational Age and Newborn Weight?—A Systematic Review

Developmental Toxicity of Fine Particulate Matter: Multifaceted Exploration from Epidemiological and Laboratory Perspectives

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