Association of Prediagnostic Frailty, Change in Frailty Status, and Mortality After Cancer Diagnosis in the Women’s Health Initiative

Feliciano, Elizabeth M. Cespedes; Hohensee, Chancellor; Rosko, Ashley; Anderson, Garnet L.; Paskett, Electra D.; Zaslavsky, Oleg; Wallace, Robert B.; Caan, Bette J.

doi:10.1001/jamanetworkopen.2020.16747

Cited by 26 publications

(25 citation statements)

References 39 publications

(106 reference statements)

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“…Of these studies, twelve reported the incidence of post-operative complications, four studies reported the incidence of thirty-day mortality and three studies reported long-term survival outcomes. In all but two studies reporting the median/mean age [ 21 , 22 ], the majority included patients aged 70 years or older. Over 80% ( n = 81, 803) of patients included were from a single study by Lo and co-workers [ 23 ], who found approximately 20% of patients were frail (MFI-5 ≥ 2).…”

Section: Resultsmentioning

confidence: 99%

“…The relationship between frailty and overall survival is shown in Table 4 . Three studies including 1, 569 patients reported the association between frailty and overall survival [ 22 , 34 , 35 ]. Artiles-Armas and co-workers reported a mean follow-up of 5 years only [ 34 ].…”

Section: Resultsmentioning

confidence: 99%

“…Mima and co-workers reported a median follow-up of 3.5 years (interquartile range: 2.5–5.1 years, [ 35 ]. Feliciano and co-workers reported a median follow-up of 5.8 years (interquartile range: 1 month-19.9 years, [ 22 ]. Frailty, defined by the CSHA-CFS and frailty phenotype, was found to be significantly associated with overall survival in two studies (Both, P < 0.001 [ 22 , 35 ].…”

Section: Resultsmentioning

confidence: 99%

“…Feliciano and co-workers reported a median follow-up of 5.8 years (interquartile range: 1 month-19.9 years, [ 22 ]. Frailty, defined by the CSHA-CFS and frailty phenotype, was found to be significantly associated with overall survival in two studies (Both, P < 0.001 [ 22 , 35 ]. In both studies this association was found to be of moderate strength (HR 2.40, 95% CI 1.40–2.99, P < 0.001 and HR 1.94, 95% CI 1.39–2.69, P < 0.001, See Table 4 ).…”

Section: Resultsmentioning

confidence: 99%

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The prevalence and prognostic value of frailty screening measures in patients undergoing surgery for colorectal cancer: observations from a systematic review

et al. 2022

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Introduction Frailty is a complex multifactorial syndrome characterised by a significant increase in vulnerability and worsened health outcomes. Despite a range of proposed frailty screening measures, the prevalence and prognostic value of frailty in patients undergoing surgery for colorectal cancer is not clear. Aim The aim of this present review was to examine the use of commonly employed frailty screening measures in patients undergoing surgery for colorectal cancer. Methods A systematic search of PubMed and Medline was carried out to identify studies reporting the use of frailty screening tools or measures in patients undergoing surgery for colorectal cancer. The screening measure used and prevalence of frailty within the population were recorded. Outcomes of interest were the incidence of post-operative complications, 30-day mortality and overall survival. Results Of the 15 studies included (n = 97, 898 patients), 9 studies were retrospective and included patients aged 70 years or older (n = 96, 120 patients). 5 of 12 studies reported that frailty was independently associated with the incidence of post-operative complications. There was also evidence that frailty was independently associated with 30-day mortality (1 of 4 studies, n = 9, 252 patients) and long-term survival (2 of 3 studies, n = 1, 420 patients). Conclusions Frailty was common in patients with colorectal cancer and the assessment of frailty may have prognostic value in patients undergoing surgery. However, the basis of the relationship between frailty and post-operative outcomes is not clear and merits further study.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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The prevalence and prognostic value of frailty screening measures in patients undergoing surgery for colorectal cancer: observations from a systematic review

et al. 2022

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“…Two included studies explored the role of prefrailty in predicting the risks of overall mortality in patients with lung cancer (22,23). Figure 2B showed forest plots, which showed the HR of the association between prefrailty and overall mortality.…”

Section: Overall Mortalitymentioning

confidence: 99%

Impacts of Frailty on Prognosis in Lung Cancer Patients: A Systematic Review and Meta-Analysis

et al. 2021

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Background: Frailty is a common geriatric syndrome and is described as a limited ability to compensate and recover from stressors. Lung cancer is largely diagnosed in old age, when frailty is common and might have predictive value on prognosis. Therefore, we performed a systematic review to evaluate the prognostic role of frailty in lung cancer.Methods: The online PubMed, Web of Science, CNKI and Wanfang literature databases were searched to identify all related articles that reported the predictive value of frailty for mortality and therapeutic toxicity. Review Manager 5.3 was used to analyze results by standard meta-analysis methodology.Results: Seven studies were included in this review, and only six studies with 2,359 patients were enrolled in meta-analysis. Patients in two studies received chemotherapy, two studies radiotherapy, two studies surgery, one study not reported. Compared to non-frail patients, frail patients had a higher risk of overall mortality [Hazard Ratio (HR) = 1.57, 95% confidence interval (CI), 1.32–1.87], and therapeutic toxicity [Odds Ratio (OR) = 2.60, 95% CI, 0.82–8.24]. Prefrail patients also showed higher overall mortality and therapeutic toxicity than non-frail patients (HR = 1.20, 95% CI, 1.05–1.38; OR = 1.72, 95% CI, 1.18–2.51, respectively).Conclusions: Frailty is a powerful predictor of overall mortality and therapeutic toxicity in lung cancer patients.

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Applying a Life Course Biological Age Framework to Improving the Care of Individuals With Adult Cancers

et al. 2021

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Association of Prediagnostic Frailty, Change in Frailty Status, and Mortality After Cancer Diagnosis in the Women’s Health Initiative

Abstract: This cohort study investigates associations of prediagnostic frailty and change in frailty status with mortality after cancer diagnosis.

Cited by 26 publications

References 39 publications

The prevalence and prognostic value of frailty screening measures in patients undergoing surgery for colorectal cancer: observations from a systematic review

The prevalence and prognostic value of frailty screening measures in patients undergoing surgery for colorectal cancer: observations from a systematic review

Impacts of Frailty on Prognosis in Lung Cancer Patients: A Systematic Review and Meta-Analysis

Applying a Life Course Biological Age Framework to Improving the Care of Individuals With Adult Cancers

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